[{"data":1,"prerenderedAt":252},["ShallowReactive",2],{"drug-acetaminophen-codeine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":82,"contraindications":111,"warnings":132,"renal":133,"monitoring":134,"interactions":135,"review":136,"examples":139,"atc":145,"iran":147,"links":191,"populations":212,"usApproval":247},"acetaminophen-codeine",1,{"fa":7,"en":8},"استامینوفن کدئین","Acetaminophen\u002Fcodeine","nervous-system",{"fa":11,"en":12},"ضددرد اپیوئیدی ترکیبی","Opioid combination analgesic",[14],{"name":15,"market":16},"Tylenol with Codeine","US",[18,19,7,20,21],"tylenol 3","tylenol codeine","استامینوفن کدیین","کدئین",[23,50,66],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"components":31,"markets":46,"refs":47},"tab-300-15","tablet","oral","Acetaminophen 300 mg + codeine 15 mg",{"amount":29,"unit":30,"perUnit":25},15,"mg",{"codeine":32,"acetaminophen":35},{"name":33,"amount":29,"unit":30},{"fa":21,"en":34},"Codeine",{"name":36,"amount":39,"unit":30,"limits":40},{"fa":37,"en":38},"استامینوفن","Acetaminophen",300,{"maxPerDay":41,"refs":42},4000,[43],{"source":44,"section":45},"fda-tylenol3","Boxed Warning",[16],[48],{"source":44,"section":49},"How Supplied",{"id":51,"form":25,"route":26,"label":52,"concentration":53,"components":55,"markets":63,"refs":64},"tab-300-30","Acetaminophen 300 mg + codeine 30 mg",{"amount":54,"unit":30,"perUnit":25},30,{"codeine":56,"acetaminophen":58},{"name":57,"amount":54,"unit":30},{"fa":21,"en":34},{"name":59,"amount":39,"unit":30,"limits":60},{"fa":37,"en":38},{"maxPerDay":41,"refs":61},[62],{"source":44,"section":45},[16],[65],{"source":44,"section":49},{"id":67,"form":25,"route":26,"label":68,"concentration":69,"components":71,"markets":79,"refs":80},"tab-300-60","Acetaminophen 300 mg + codeine 60 mg",{"amount":70,"unit":30,"perUnit":25},60,{"codeine":72,"acetaminophen":74},{"name":73,"amount":70,"unit":30},{"fa":21,"en":34},{"name":75,"amount":39,"unit":30,"limits":76},{"fa":37,"en":38},{"maxPerDay":41,"refs":77},[78],{"source":44,"section":45},[16],[81],{"source":44,"section":49},[83],{"id":84,"disease":84,"label":85,"population":88,"type":92,"unit":30,"dose":93,"refs":96,"doseComponent":99,"limits":100,"notes":104},"pain",{"fa":86,"en":87},"درد — بزرگسال: ۱ تا ۲ قرص هر ۴ ساعت در صورت نیاز","Pain — adults: 1–2 tablets every 4 h as needed",{"minAge":89},{"value":90,"unit":91},18,"year","fixed",{"perDose":54,"perDoseMax":70,"dosesPerDay":94,"intervalHours":95},6,4,[97],{"source":44,"section":98},"Dosage and Administration","codeine",{"maxPerDay":101,"refs":102},360,[103],{"source":44,"section":98},[105],{"text":106,"refs":109},{"fa":107,"en":108},"۳۰۰ تا ۶۰۰ mg استامینوفن + ۳۰ تا ۶۰ mg کدئین هر ۴ ساعت؛ کمترین دوز مؤثر. حداکثر استامینوفن ۴ g\u002Fday از همه منابع.","300–600 mg acetaminophen + 30–60 mg codeine every 4 h; lowest effective dose. Acetaminophen max 4 g\u002Fday from all sources.",[110],{"source":44,"section":98},[112,124],{"id":113,"severity":114,"rule":115,"text":118,"refs":121},"under-12","block",{"maxAge":116},{"value":117,"unit":91},12,{"fa":119,"en":120},"زیر ۱۲ سال منع مصرف (دپرسیون تنفسی کشنده)؛ پس از تونسیلکتومی زیر ۱۸ سال.","Contraindicated under 12 (fatal respiratory depression); after tonsillectomy under 18.",[122],{"source":44,"section":123},"Contraindications",{"id":125,"severity":126,"text":127,"refs":130},"boxed","warn",{"fa":128,"en":129},"هشدار جعبه‌ای: اعتیاد، دپرسیون تنفسی، متابولیسم فوق‌سریع کدئین، سمیت کبدی استامینوفن، تداخل با بنزودیازپین‌ها.","Boxed warning: addiction, respiratory depression, ultra-rapid codeine metabolism, acetaminophen hepatotoxicity, benzodiazepine interaction.",[131],{"source":44,"section":45},[],[],[],[],{"status":137,"reviewer":138,"date":138},"unverified",null,[140],{"regimen":84,"formulation":51,"input":141,"expect":144},{"ageYears":142,"weightKg":143},40,70,{"perDose":54,"tabletsPerDoseRounded":5,"upperPerDose":70},[146],"N02AJ06",{"status":148,"forms":149,"refs":186},"registered",[150,154,158,162,166,170,174,178,182],{"code":151,"en":152,"fa":153},"08440","ACETAMINOPHEN CODEINE (300+10)MG TAB","قرص استامینوفن کدئین (۳۰۰ + ۱۰) میلی‌گرم",{"code":155,"en":156,"fa":157},"02243","ACETAMINOPHEN CODEINE (300+20) TAB","قرص استامینوفن کدئین (۳۰۰ + ۲۰)",{"code":159,"en":160,"fa":161},"07716","ACETAMINOPHEN CODEINE (500+30) MG TAB","قرص استامینوفن کدئین (۵۰۰ + ۳۰) میلی‌گرم",{"code":163,"en":164,"fa":165},"00010","ACETAMINOPHEN CODEINE (500+8) TAB","قرص استامینوفن کدئین (۵۰۰ + ۸)",{"code":167,"en":168,"fa":169},"18838","ACETAMINOPHEN CODEINE 300\u002F10MG SOFT GEL CAP","کپسول نرم استامینوفن کدئین ۳۰۰ \u002F ۱۰ میلی‌گرم",{"code":171,"en":172,"fa":173},"02404","ACETAMINOPHEN CODEINE EFF TAB","قرص جوشان استامینوفن کدئین",{"code":175,"en":176,"fa":177},"52500","ACETAMINOPHEN \u002F CODEINE PHOSPHATE CAPSULE, LIQUID FILLED ORAL 300 mg\u002F20 mg","کپسول استامینوفن \u002F کدئین فسفات پرشده ۳۰۰ میلی‌گرم \u002F ۲۰ میلی‌گرم",{"code":179,"en":180,"fa":181},"52312","ACETAMINOPHEN \u002F CODEINE PHOSPHATE TABLET ORAL 300 mg\u002F10 mg","قرص استامینوفن \u002F کدئین فسفات ۳۰۰ میلی‌گرم \u002F ۱۰ میلی‌گرم",{"code":183,"en":184,"fa":185},"52922","ACETAMINOPHEN \u002F CODEINE PHOSPHATE TABLET ORAL 500 mg\u002F8 mg","قرص استامینوفن \u002F کدئین فسفات ۵۰۰ میلی‌گرم \u002F ۸ میلی‌گرم",[187],{"source":188,"section":189,"url":190},"darooyab-generic","G-4643\u002FAcetaminophen-Codeine","https:\u002F\u002Fwww.darooyab.ir\u002FG-4643\u002FAcetaminophen-Codeine",[192,196,200,203,206,209],{"kind":193,"url":194,"label":195},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=211610","ANDA211610",{"kind":197,"url":198,"label":199},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=79377617-686b-4640-b2b8-e1358cf82358","FDA APAP-codeine",{"kind":201,"url":202,"label":38},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa681004.html",{"kind":201,"url":204,"label":205},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa611019.html","Acetaminophen Injection",{"kind":207,"url":208,"label":146},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N02AJ06",{"kind":210,"url":190,"label":211},"darooyab","Acetaminophen-Codeine",{"pregnancy":213,"lactation":221,"pediatric":229,"geriatric":238},{"level":214,"text":215,"quote":218,"refs":219},"avoid",{"fa":216,"en":217},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Neonatal Opioid Withdrawal Syndrome (NOWS) Advise pregnant women using opioids for an extended period of time of the risk of Neonatal Opioid Withdrawal Syndrome, which may be life-threatening if not recognized and treated.",[220],{"source":44,"section":45},{"level":214,"text":222,"quote":225,"refs":226},{"fa":223,"en":224},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions, including excess sedation, respiratory depression, and death in a breastfed infant, advise patients that breastfeeding is not recommended during treatment with acetaminophen and codeine phosphate tablets (see WARNINGS ).",[227],{"source":44,"section":228},"Nursing Mothers",{"level":230,"text":231,"quote":234,"refs":235},"contraindicated",{"fa":232,"en":233},"برچسب: در کودکان زیر سن مشخص منع مصرف دارد.","Label: contraindicated in children below a stated age.","Acetaminophen and codeine phosphate tablets are contraindicated for: • All children younger than 12 years of age (see WARNINGS ) • Post-operative management in children younger than 18 years of age following tonsillectomy and\u002For adenoidectomy (see WARNINGS ).",[236],{"source":44,"section":237},"CONTRAINDICATIONS",{"level":239,"text":240,"quote":243,"refs":244},"caution",{"fa":241,"en":242},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, use caution when selecting a dosage for an elderly patient, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function and of concomitant disease or other drug therapy.",[245],{"source":44,"section":246},"Geriatric Use",{"kind":248,"refs":249,"id":195},"ANDA",[250],{"source":44,"section":251},"SPL approval \u002F marketing category",1792191876367]