[{"data":1,"prerenderedAt":186},["ShallowReactive",2],{"drug-amlodipine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":19,"regimens":34,"contraindications":81,"warnings":91,"renal":92,"monitoring":93,"interactions":94,"review":95,"examples":98,"atc":109,"iran":111,"links":131,"populations":148,"usApproval":181},"amlodipine",1,{"fa":7,"en":8},"آملودیپین","Amlodipine","cardiovascular",{"fa":11,"en":12},"مسدودکننده کانال کلسیم","Calcium channel blocker",[14],{"name":15,"market":16},"Norvasc","US",[7,18],"norvasc",[20],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-5","tablet","oral","5 mg tablet",{"amount":26,"unit":27,"perUnit":22,"scored":28},5,"mg",false,[16],[31],{"source":32,"section":33},"fda-amlodipine","3",[35,62],{"id":36,"disease":37,"label":38,"population":41,"type":47,"unit":27,"dose":48,"refs":50,"notes":55},"htn-child","hypertension",{"fa":39,"en":40},"فشار خون ۶ تا ۱۷ سال — ۲٫۵ تا ۵ mg روزانه","Hypertension 6–17 y — 2.5–5 mg daily",{"minAge":42,"maxAge":45},{"value":43,"unit":44},6,"year",{"value":46,"unit":44},18,"fixed",{"perDose":49,"perDoseMax":26,"dosesPerDay":5},2.5,[51,53],{"source":32,"section":52},"2.2",{"source":32,"section":54},"8.4",[56],{"text":57,"refs":60},{"fa":58,"en":59},"بالای ۵ mg در کودکان مطالعه نشده است.","Doses above 5 mg not studied in children.",[61],{"source":32,"section":52},{"id":63,"disease":37,"label":64,"population":67,"type":47,"unit":27,"dose":69,"refs":71,"notes":74},"htn-adult",{"fa":65,"en":66},"بزرگسال — شروع ۵ mg روزانه (حداکثر ۱۰ mg)","Adults — start 5 mg daily (max 10 mg)",{"minAge":68},{"value":46,"unit":44},{"perDose":26,"perDoseMax":70,"dosesPerDay":5},10,[72],{"source":32,"section":73},"2.1",[75],{"text":76,"refs":79},{"fa":77,"en":78},"سالمند، ضعیف یا نارسایی کبد: شروع ۲٫۵ mg؛ ۷ تا ۱۴ روز بین افزایش‌ها.","Small, fragile, elderly or hepatic insufficiency: start 2.5 mg; wait 7–14 days between titration steps.",[80],{"source":32,"section":73},[82],{"id":83,"severity":84,"text":85,"refs":88},"hypersensitivity","block",{"fa":86,"en":87},"حساسیت به آملودیپین.","Known sensitivity to amlodipine.",[89],{"source":32,"section":90},"4",[],[],[],[],{"status":96,"reviewer":97,"date":97},"unverified",null,[99,104],{"regimen":63,"formulation":21,"input":100,"expect":103},{"ageYears":101,"weightKg":102},50,80,{"perDose":26,"tabletsPerDoseRounded":5,"upperPerDose":70},{"regimen":36,"formulation":21,"input":105,"expect":107},{"ageYears":70,"weightKg":106},30,{"status":108},"blocked",[110],"C08CA01",{"status":112,"forms":113,"refs":126},"registered",[114,118,122],{"code":115,"en":116,"fa":117},"10691","AMLODIPINE 10MG TAB","قرص آملودیپین ۱۰ میلی‌گرم",{"code":119,"en":120,"fa":121},"10665","AMLODIPINE 2.5MG TAB","قرص آملودیپین ۲٫۵ میلی‌گرم",{"code":123,"en":124,"fa":125},"00070","AMLODIPINE 5MG TAB","قرص آملودیپین ۵ میلی‌گرم",[127],{"source":128,"section":129,"url":130},"darooyab-generic","G-1522\u002FAmlodipine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1522\u002FAmlodipine",[132,136,140,143,146],{"kind":133,"url":134,"label":135},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=078925","ANDA078925",{"kind":137,"url":138,"label":139},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=204f27e9-5041-4677-b313-866ca69abad9","FDA Amlodipine",{"kind":141,"url":142,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa692044.html",{"kind":144,"url":145,"label":110},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C08CA01",{"kind":147,"url":130,"label":8},"darooyab",{"pregnancy":149,"lactation":158,"pediatric":166,"geriatric":173},{"level":150,"text":151,"quote":154,"refs":155},"caution",{"fa":152,"en":153},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary The limited available data based on post-marketing reports with amlodipine use in pregnant women are not sufficient to inform a drug-associated risk for major birth defects and miscarriage.",[156],{"source":32,"section":157},"8.1",{"level":150,"text":159,"quote":162,"refs":163},{"fa":160,"en":161},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Limited available data from a published clinical lactation study reports that amlodipine is present in human milk at an estimated median relative infant dose of 4.2%.",[164],{"source":32,"section":165},"8.2",{"level":150,"text":167,"quote":170,"refs":171},{"fa":168,"en":169},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Amlodipine besylate tablets (2.5 to 5 mg daily) is effective in lowering blood pressure in patients 6 to 17 years [see Clinical Studies (14.1) ] .",[172],{"source":32,"section":54},{"level":150,"text":174,"quote":177,"refs":178},{"fa":175,"en":176},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[179],{"source":32,"section":180},"8.5",{"kind":182,"refs":183,"id":135},"ANDA",[184],{"source":32,"section":185},"SPL approval \u002F marketing category",1792191868745]