[{"data":1,"prerenderedAt":181},["ShallowReactive",2],{"drug-bupropion":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":76,"warnings":86,"renal":87,"monitoring":88,"interactions":89,"review":90,"examples":93,"atc":102,"iran":104,"links":124,"populations":141,"usApproval":176},"bupropion",1,{"fa":7,"en":8},"بوپروپیون","Bupropion","nervous-system",{"fa":11,"en":12},"ضدافسردگی (NDRI)","Antidepressant (NDRI)",[14],{"name":15,"market":16},"Wellbutrin XL","US",[18,19,7],"wellbutrin","ولبوترین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-150","tablet","oral","150 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},150,"mg",false,[16],[32],{"source":33,"section":34},"fda-bupropion-xl","3",[36,62],{"id":37,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":51,"notes":54},"mdd",{"fa":39,"en":40},"افسردگی — بزرگسال: ۱۵۰ mg صبح، پس از ۴ روز ۳۰۰","MDD — adults: 150 mg morning, 300 after 4 days",{"minAge":42},{"value":43,"unit":44},18,"year","titration",{"dividedDoses":5,"titration":47},{"start":27,"increment":27,"incrementEveryDays":48,"targetMin":49,"targetMax":49,"max":50},4,300,450,[52],{"source":33,"section":53},"2.2",[55],{"text":56,"refs":59},{"fa":57,"en":58},"برای کاهش خطر تشنج تدریجی افزایش یابد؛ قرص کامل بلعیده شود.","Increase gradually to reduce seizure risk; 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use only if needed, under medical advice.","Risk Summary Data from epidemiological studies of pregnant women exposed to bupropion in the first trimester have not identified an increased risk of congenital malformations overall (see Data).",[149],{"source":33,"section":150},"8.1",{"level":143,"text":152,"quote":155,"refs":156},{"fa":153,"en":154},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Data from published literature report the presence of bupropion and its metabolites in human milk (see Data).",[157],{"source":33,"section":158},"8.2",{"level":160,"text":161,"quote":164,"refs":165},"avoid",{"fa":162,"en":163},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","SUICIDALITY AND ANTIDEPRESSANT DRUGS Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials.",[166],{"source":33,"section":167},"Boxed Warning",{"level":143,"text":169,"quote":172,"refs":173},{"fa":170,"en":171},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, it may be necessary to consider this factor in dose selection; it may be useful to monitor renal function [see Dosage and Administration ( 2.7 ), Use in Specific Populations ( 8.6 ), and Clinical Pharmacology ( 12.3 )] .",[174],{"source":33,"section":175},"8.5",{"kind":177,"refs":178,"id":128},"ANDA",[179],{"source":33,"section":180},"SPL approval \u002F marketing category",1792191877460]