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then 200 mg twice daily as needed.",[124],{"source":33,"section":117},{"id":126,"disease":127,"label":128,"population":131,"type":135,"unit":28,"dose":136,"refs":143,"notes":148},"jra","juvenile-arthritis",{"fa":129,"en":130},"آرتریت روماتوئید نوجوانان — ۲ سال به بالا: بر اساس وزن","Juvenile RA — ≥2 y: by weight",{"minAge":132,"maxAge":133,"minWeightKg":134},{"value":84,"unit":69},{"value":68,"unit":69},10,"weightBand",{"weightBands":137},[138,141],{"minWeightKg":139,"maxWeightKg":140,"perDose":27,"dosesPerDay":84},9.99,25,{"minWeightKg":140,"maxWeightKg":142,"perDose":39,"dosesPerDay":84},null,[144,146],{"source":33,"section":145},"2.4",{"source":33,"section":147},"2",[149],{"text":150,"refs":153},{"fa":151,"en":152},"۱۰ تا ۲۵ kg: ۵۰ mg دو بار؛ بالای ۲۵ kg: ۱۰۰ mg دو بار.","10–25 kg: 50 mg twice daily; >25 kg: 100 mg twice daily.",[154],{"source":33,"section":147},[156,167],{"id":157,"severity":158,"text":159,"refs":162},"ci","block",{"fa":160,"en":161},"حساسیت به سلکوکسیب؛ جراحی CABG (و سایر موارد بخش ۴).","Hypersensitivity to celecoxib; CABG surgery (and other items in section 4).",[163,165],{"source":33,"section":164},"4",{"source":33,"section":166},"Boxed Warning",{"id":168,"severity":169,"text":170,"refs":173},"boxed","warn",{"fa":171,"en":172},"هشدار جعبه‌ای: خطر حوادث قلبی‌عروقی ترومبوتیک و خونریزی، زخم و سوراخ‌شدگی گوارشی.","Boxed warning: risk of serious cardiovascular thrombotic events and GI bleeding, ulceration and perforation.",[174],{"source":33,"section":166},[],[],[],[],{"status":180,"reviewer":142,"date":142},"unverified",[182,187,191,195,199,204],{"regimen":61,"formulation":44,"input":183,"expect":186},{"ageYears":184,"weightKg":185},60,75,{"perDose":47},{"regimen":76,"formulation":36,"input":188,"expect":190},{"ageYears":27,"weightKg":189},70,{"perDose":39,"upperPerDose":47},{"regimen":89,"formulation":44,"input":192,"expect":194},{"ageYears":193,"weightKg":185},35,{"perDose":47},{"regimen":108,"formulation":44,"input":196,"expect":198},{"ageYears":197,"weightKg":189},30,{"perDay":55},{"regimen":126,"formulation":22,"input":200,"expect":203},{"ageYears":201,"weightKg":202},6,20,{"perDose":27},{"regimen":126,"formulation":36,"input":205,"expect":208},{"ageYears":206,"weightKg":207},12,40,{"perDose":39},[210],"M01AH01",{"status":212,"forms":213,"refs":226},"registered",[214,218,222],{"code":215,"en":216,"fa":217},"01913","CELECOXIB 100MG CAP","کپسول سلکوکسیب ۱۰۰ میلی‌گرم",{"code":219,"en":220,"fa":221},"01932","CELECOXIB 200MG CAP","کپسول سلکوکسیب ۲۰۰ میلی‌گرم",{"code":223,"en":224,"fa":225},"53361","CELECOXIB 400MG CAP","کپسول سلکوکسیب ۴۰۰ میلی‌گرم",[227],{"source":228,"section":229,"url":230},"darooyab-generic","G-41\u002FCelecoxib","https:\u002F\u002Fwww.darooyab.ir\u002FG-41\u002FCelecoxib",[232,236,240,243,246],{"kind":233,"url":234,"label":235},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=200562","ANDA200562",{"kind":237,"url":238,"label":239},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=05224473-27dc-4f6d-a52a-c40a7af2f2f4","FDA Celecoxib",{"kind":241,"url":242,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699022.html",{"kind":244,"url":245,"label":210},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M01AH01",{"kind":247,"url":230,"label":8},"darooyab",{"pregnancy":249,"lactation":258,"pediatric":267,"geriatric":275,"reproductive":282},{"level":250,"text":251,"quote":254,"refs":255},"avoid",{"fa":252,"en":253},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Clinical Considerations Fetal\u002FNeonatal Adverse Reactions Premature Closure of Fetal Ductus Arteriosus: Avoid use of NSAIDs in women at about 30 weeks gestation and later in pregnancy, because NSAIDs, including celecoxib, can cause premature closure of the fetal ductus arteriosus (see Data) .",[256],{"source":33,"section":257},"8.1",{"level":259,"text":260,"quote":263,"refs":264},"caution",{"fa":261,"en":262},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when celecoxib is administered to a nursing woman.",[265],{"source":33,"section":266},"8.2",{"level":259,"text":268,"quote":271,"refs":272},{"fa":269,"en":270},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Celecoxib is approved for relief of the signs and symptoms of Juvenile Rheumatoid Arthritis in patients 2 years and older.",[273],{"source":33,"section":274},"8.4",{"level":259,"text":276,"quote":279,"refs":280},{"fa":277,"en":278},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Elderly patients and patients with a prior history of peptic ulcer disease and\u002For GI bleeding are at greater risk for serious GI events [see Warnings and Precautions (5.2) ] .",[281],{"source":33,"section":166},{"level":259,"text":283,"quote":286,"refs":287},{"fa":284,"en":285},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Females Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including celecoxib, may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women.",[288],{"source":33,"section":289},"8.3",{"kind":291,"refs":292,"id":235},"ANDA",[293],{"source":33,"section":294},"SPL approval \u002F marketing category",1792191875576]