[{"data":1,"prerenderedAt":215},["ShallowReactive",2],{"drug-citalopram":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":12,"synonyms":16,"formulations":19,"regimens":51,"contraindications":91,"warnings":108,"renal":116,"monitoring":117,"interactions":118,"review":119,"examples":122,"atc":128,"iran":130,"links":158,"populations":175,"usApproval":210},"citalopram",1,{"fa":7,"en":8},"سیتالوپرام","Citalopram","nervous-system",{"fa":11,"en":11},"SSRI",[13],{"name":14,"market":15},"Celexa","US",[17,7,18],"celexa","سیپرالکس",[20,34,43],{"id":21,"form":22,"route":23,"label":24,"concentration":25,"markets":29,"refs":30},"tab-10","tablet","oral","10 mg tablet",{"amount":26,"unit":27,"perUnit":22,"scored":28},10,"mg",false,[15],[31],{"source":32,"section":33},"fda-celexa","3",{"id":35,"form":22,"route":23,"label":36,"concentration":37,"markets":40,"refs":41},"tab-20","20 mg tablet (scored)",{"amount":38,"unit":27,"perUnit":22,"scored":39},20,true,[15],[42],{"source":32,"section":33},{"id":44,"form":22,"route":23,"label":45,"concentration":46,"markets":48,"refs":49},"tab-40","40 mg tablet (scored)",{"amount":47,"unit":27,"perUnit":22,"scored":39},40,[15],[50],{"source":32,"section":33},[52,76],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":27,"dose":63,"refs":66,"notes":69},"mdd-adult","mdd",{"fa":56,"en":57},"افسردگی — بزرگسال: ۲۰ mg روزانه (حداکثر ۴۰)","MDD — adults: 20 mg daily (max 40)",{"minAge":59},{"value":60,"unit":61},18,"year","titration",{"dividedDoses":5,"titration":64},{"start":38,"increment":38,"incrementEveryDays":65,"max":47},7,[67],{"source":32,"section":68},"2.1",[70],{"text":71,"refs":74},{"fa":72,"en":73},"بالای ۴۰ mg به علت طولانی شدن QT توصیه نمی‌شود.","Doses above 40 mg not recommended due to QT prolongation.",[75],{"source":32,"section":68},{"id":77,"disease":54,"label":78,"population":81,"type":83,"unit":27,"dose":84,"refs":88},"child",{"fa":79,"en":80},"کودکان","Children",{"maxAge":82},{"value":60,"unit":61},"notCalculated",{"reason":85},{"fa":86,"en":87},"بی‌خطری و اثربخشی سیتالوپرام در کودکان ثابت نشده است.","Safety and effectiveness of citalopram in pediatric patients have not been established.",[89],{"source":32,"section":90},"8.4",[92,101],{"id":93,"severity":94,"text":95,"refs":98},"maoi","block",{"fa":96,"en":97},"مصرف MAOI (شامل لینزولید یا متیلن بلو وریدی) یا تا ۱۴ روز پس از قطع آن.","Taking an MAOI (incl. linezolid or IV methylene blue) or within 14 days of stopping.",[99],{"source":32,"section":100},"4",{"id":102,"severity":94,"text":103,"refs":106},"pimozide",{"fa":104,"en":105},"مصرف پیموزاید (QT)؛ حساسیت.","Pimozide (QT prolongation); hypersensitivity.",[107],{"source":32,"section":100},[109],{"text":110,"refs":113},{"fa":111,"en":112},"هشدار جعبه‌ای: افزایش خطر افکار و رفتار خودکشی در کودکان و جوانان؛ پایش دقیق. سیتالوپرام برای کودکان تأیید نشده است.","Boxed warning: Increased risk of suicidal thoughts and behaviors in pediatric and young adult patients; monitor closely. Not approved for pediatric use.",[114],{"source":32,"section":115},"WARNING: SUICIDAL THOUGHTS AND BEHAVIORS",[],[],[],{"status":120,"reviewer":121,"date":121},"unverified",null,[123],{"regimen":53,"formulation":35,"input":124,"expect":127},{"ageYears":125,"weightKg":126},30,70,{"perDose":38,"tabletsPerDoseRounded":5},[129],"N06AB04",{"status":131,"forms":132,"refs":153},"registered",[133,137,141,145,149],{"code":134,"en":135,"fa":136},"13057","CITALOPRAM \u003CACCORD> 20 MG  TAB.","قرص سیتالوپرام \u003C آککورد > ۲۰ میلی‌گرم .",{"code":138,"en":139,"fa":140},"08454","CITALOPRAM HBR 10MG FC TAB","قرص روکش‌دار سیتالوپرام هیدروبروماید ۱۰ میلی‌گرم",{"code":142,"en":143,"fa":144},"01905","CITALOPRAM HBR 20MG FC TAB","قرص روکش‌دار سیتالوپرام هیدروبروماید ۲۰ میلی‌گرم",{"code":146,"en":147,"fa":148},"01906","CITALOPRAM HBR 40MG FC TAB","قرص روکش‌دار سیتالوپرام هیدروبروماید ۴۰ میلی‌گرم",{"code":150,"en":151,"fa":152},"02118","CITALOPRAM HBR 40MG\u002FML ORAL DROP","قطره خوراکی سیتالوپرام هیدروبروماید ۴۰ میلی‌گرم \u002F میلی‌لیتر",[154],{"source":155,"section":156,"url":157},"darooyab-generic","G-576\u002FCitalopram","https:\u002F\u002Fwww.darooyab.ir\u002FG-576\u002FCitalopram",[159,163,167,170,173],{"kind":160,"url":161,"label":162},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020822","NDA020822",{"kind":164,"url":165,"label":166},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4259d9b1-de34-43a4-85a8-41dd214e9177","FDA Celexa",{"kind":168,"url":169,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699001.html",{"kind":171,"url":172,"label":129},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06AB04",{"kind":174,"url":157,"label":8},"darooyab",{"pregnancy":176,"lactation":185,"pediatric":193,"geriatric":202},{"level":177,"text":178,"quote":181,"refs":182},"caution",{"fa":179,"en":180},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Based on data from published observational studies, exposure to SSRIs, particularly in the month before delivery, has been associated with a less than 2-fold increase in the risk of postpartum hemorrhage [see Warnings and Precautions ( 5.4 ) and Clinical Considerations] .",[183],{"source":32,"section":184},"8.1",{"level":177,"text":186,"quote":189,"refs":190},{"fa":187,"en":188},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Data from the published literature report the presence of citalopram in human milk at relative infant doses ranging between 0.7 to 9.4% of the maternal weight-adjusted dosage and a milk\u002Fplasma ratio ranging between 0.78 to 4.3.",[191],{"source":32,"section":192},"8.2",{"level":194,"text":195,"quote":198,"refs":199},"avoid",{"fa":196,"en":197},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Antidepressants increased the risk of suicidal thoughts and behaviors in pediatric and young adult patients in short -term studies .",[200],{"source":32,"section":201},"Boxed Warning",{"level":177,"text":203,"quote":206,"refs":207},{"fa":204,"en":205},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Therefore, the maximum recommended dosage in patients 60 years of age and older is lower than younger patients [see Dosage and Administration ( 2.3 ) , Warnings and Precautions ( 5.2 ) ] .",[208],{"source":32,"section":209},"8.5",{"kind":211,"refs":212,"id":162},"NDA",[213],{"source":32,"section":214},"SPL approval \u002F marketing category",1792440737421]