[{"data":1,"prerenderedAt":210},["ShallowReactive",2],{"drug-clopidogrel":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":44,"contraindications":105,"warnings":115,"renal":116,"monitoring":117,"interactions":118,"review":119,"examples":122,"atc":135,"iran":137,"links":153,"populations":170,"usApproval":205},"clopidogrel",1,{"fa":7,"en":8},"کلوپیدوگرل","Clopidogrel","blood",{"fa":11,"en":12},"مهارکننده P2Y12 (ضدپلاکت)","P2Y12 inhibitor (antiplatelet)",[14],{"name":15,"market":16},"Plavix","US",[18,19,7,20],"plavix","پلاویکس","ضد پلاکت",[22,36],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-75","tablet","oral","75 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},75,"mg",false,[16],[33],{"source":34,"section":35},"fda-clopidogrel","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-300","300 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},300,[16],[43],{"source":34,"section":35},[45,68,78,90],{"id":46,"disease":47,"label":48,"population":51,"type":55,"unit":29,"dose":56,"refs":57,"durationDays":60,"notes":61},"acs-load","acute-coronary-syndrome",{"fa":49,"en":50},"سندرم حاد کرونری — دوز بارگیری ۳۰۰ mg (یک‌بار)","ACS — loading dose 300 mg (once)",{"minAge":52},{"value":53,"unit":54},18,"year","fixed",{"perDose":40,"dosesPerDay":5},[58],{"source":34,"section":59},"2.1",{"min":5,"max":5},[62],{"text":63,"refs":66},{"fa":64,"en":65},"سپس ۷۵ mg یک بار در روز. بدون دوز بارگیری، اثر ضدپلاکتی چند روز دیرتر می‌رسد.","Then 75 mg once daily. Without a loading dose the antiplatelet effect is delayed by several days.",[67],{"source":34,"section":59},{"id":69,"disease":47,"label":70,"population":73,"type":55,"unit":29,"dose":75,"refs":76},"maint",{"fa":71,"en":72},"سندرم حاد کرونری — نگهدارنده ۷۵ mg یک بار در روز","ACS — maintenance 75 mg once daily",{"minAge":74},{"value":53,"unit":54},{"perDose":28,"dosesPerDay":5},[77],{"source":34,"section":59},{"id":79,"disease":80,"label":81,"population":84,"type":55,"unit":29,"dose":86,"refs":87},"prevent","atherothrombotic-prevention",{"fa":82,"en":83},"MI یا سکته مغزی اخیر، PAD — ۷۵ mg یک بار در روز","Recent MI or stroke, PAD — 75 mg once daily",{"minAge":85},{"value":53,"unit":54},{"perDose":28,"dosesPerDay":5},[88],{"source":34,"section":89},"2.2",{"id":91,"disease":80,"label":92,"population":95,"type":97,"unit":29,"dose":98,"refs":102},"peds",{"fa":93,"en":94},"زیر ۱۸ سال","Under 18 years",{"maxAge":96},{"value":53,"unit":54},"notCalculated",{"reason":99},{"fa":100,"en":101},"بی‌خطری و اثربخشی در کودکان ثابت نشده است.","Safety and effectiveness in pediatric patients not established.",[103],{"source":34,"section":104},"8.4",[106],{"id":107,"severity":108,"text":109,"refs":112},"ci","block",{"fa":110,"en":111},"خونریزی پاتولوژیک فعال (زخم پپتیک، خونریزی داخل جمجمه)؛ حساسیت.","Active pathological bleeding (peptic ulcer, intracranial haemorrhage); hypersensitivity.",[113],{"source":34,"section":114},"4",[],[],[],[],{"status":120,"reviewer":121,"date":121},"unverified",null,[123,128,132],{"regimen":46,"formulation":37,"input":124,"expect":127},{"ageYears":125,"weightKg":126},60,80,{"perDose":40},{"regimen":79,"formulation":23,"input":129,"expect":131},{"ageYears":130,"weightKg":130},70,{"perDose":28},{"regimen":69,"formulation":23,"input":133,"expect":134},{"ageYears":125,"weightKg":126},{"perDay":28},[136],"B01AC04",{"status":138,"forms":139,"refs":148},"registered",[140,144],{"code":141,"en":142,"fa":143},"01788","CLOPIDOGREL 75MG TAB","قرص کلوپیدوگرل ۷۵ میلی‌گرم",{"code":145,"en":146,"fa":147},"00367","CLOPIDOGREL 300MG TAB","قرص کلوپیدوگرل ۳۰۰ میلی‌گرم",[149],{"source":150,"section":151,"url":152},"darooyab-generic","G-1605\u002FClopidogrel","https:\u002F\u002Fwww.darooyab.ir\u002FG-1605\u002FClopidogrel",[154,158,162,165,168],{"kind":155,"url":156,"label":157},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204165","ANDA204165",{"kind":159,"url":160,"label":161},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=bb3b5e96-e629-4db5-8ad5-40c17c6dae18","FDA Clopidogrel",{"kind":163,"url":164,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601040.html",{"kind":166,"url":167,"label":136},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=B01AC04",{"kind":169,"url":152,"label":8},"darooyab",{"pregnancy":171,"lactation":180,"pediatric":188,"geriatric":196},{"level":172,"text":173,"quote":176,"refs":177},"caution",{"fa":174,"en":175},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data from cases reported in published literature and postmarketing surveillance with clopidogrel use in pregnant women have not identified any drug-associated risks for major birth defects or miscarriage [see Data ].",[178],{"source":34,"section":179},"8.1",{"level":172,"text":181,"quote":184,"refs":185},{"fa":182,"en":183},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of clopidogrel in human milk or the effects on milk production.",[186],{"source":34,"section":187},"8.2",{"level":189,"text":190,"quote":193,"refs":194},"not-established",{"fa":191,"en":192},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric populations have not been established.",[195],{"source":34,"section":104},{"level":197,"text":198,"quote":201,"refs":202},"ok",{"fa":199,"en":200},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No dosage adjustment is necessary in elderly patients.",[203],{"source":34,"section":204},"8.5",{"kind":206,"refs":207,"id":157},"ANDA",[208],{"source":34,"section":209},"SPL approval \u002F marketing category",1792440721326]