[{"data":1,"prerenderedAt":193},["ShallowReactive",2],{"drug-clozapine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":43,"contraindications":75,"warnings":104,"renal":105,"monitoring":106,"interactions":107,"review":108,"examples":111,"atc":119,"iran":121,"links":137,"populations":154,"usApproval":188},"clozapine",1,{"fa":7,"en":8},"کلوزاپین","Clozapine","nervous-system",{"fa":11,"en":12},"آنتی‌سایکوتیک آتیپیک","Atypical antipsychotic",[14],{"name":15,"market":16},"Clozaril","US",[18,19,7],"clozaril","کلوزاریل",[21,35],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-25","tablet","oral","25 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},25,"mg",true,[16],[32],{"source":33,"section":34},"fda-clozapine","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-100","100 mg tablet (scored)",{"amount":39,"unit":28,"perUnit":23,"scored":29},100,[16],[42],{"source":33,"section":34},[44],{"id":45,"disease":46,"label":47,"population":50,"type":54,"unit":28,"dose":55,"refs":62,"notes":67},"scz","schizophrenia",{"fa":48,"en":49},"اسکیزوفرنی مقاوم — شروع ۱۲٫۵ mg یک یا دو بار","Treatment-resistant schizophrenia — start 12.5 mg once or twice daily",{"minAge":51},{"value":52,"unit":53},18,"year","titration",{"dividedDoses":56,"titration":57},2,{"start":27,"increment":58,"incrementEveryDays":5,"targetMin":59,"targetMax":60,"max":61},50,300,450,900,[63,65],{"source":33,"section":64},"2.2",{"source":33,"section":66},"2",[68],{"text":69,"refs":72},{"fa":70,"en":71},"افزایش ۲۵ تا ۵۰ mg\u002Fday تا هدف ۱۵۰ تا ۲۲۵ mg دو بار؛ حداکثر ۴۵۰ mg دو بار. پایش شمارش نوتروفیل الزامی است.","Increase by 25–50 mg\u002Fday to target 150–225 mg twice daily; max 450 mg twice daily. Neutrophil monitoring required.",[73,74],{"source":33,"section":66},{"source":33,"section":64},[76,85,94],{"id":77,"severity":78,"text":79,"refs":82},"ci","block",{"fa":80,"en":81},"حساسیت به کلوزاپین.","Hypersensitivity to clozapine.",[83],{"source":33,"section":84},"4",{"id":86,"severity":87,"text":88,"refs":91},"boxed","warn",{"fa":89,"en":90},"هشدار جعبه‌ای: نوتروپنی شدید، افت فشار ارتوستاتیک و سنکوپ، تشنج، میوکاردیت، مرگ در سالمندان با دمانس.","Boxed warning: severe neutropenia, orthostatic hypotension and syncope, seizures, myocarditis, mortality in elderly dementia patients.",[92],{"source":33,"section":93},"Boxed Warning",{"id":95,"severity":78,"rule":96,"text":98,"refs":101},"child",{"maxAge":97},{"value":52,"unit":53},{"fa":99,"en":100},"در کودکان ثابت نشده.","Not established in children.",[102],{"source":33,"section":103},"8.4",[],[],[],[],{"status":109,"reviewer":110,"date":110},"unverified",null,[112],{"regimen":45,"formulation":22,"input":113,"expect":116},{"ageYears":114,"weightKg":115},30,70,{"perDose":117,"tabletsPerDoseRounded":118},12.5,0.5,[120],"N05AH02",{"status":122,"forms":123,"refs":132},"registered",[124,128],{"code":125,"en":126,"fa":127},"00334","CLOZAPINE 100MG TAB","قرص کلوزاپین ۱۰۰ میلی‌گرم",{"code":129,"en":130,"fa":131},"01743","CLOZAPINE 25MG TAB","قرص کلوزاپین ۲۵ میلی‌گرم",[133],{"source":134,"section":135,"url":136},"darooyab-generic","G-1260\u002FClozapine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1260\u002FClozapine",[138,142,146,149,152],{"kind":139,"url":140,"label":141},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=206433","ANDA206433",{"kind":143,"url":144,"label":145},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=61fe53d5-ed5c-4e45-9189-709d08d386cb","FDA Clozapine",{"kind":147,"url":148,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa691001.html",{"kind":150,"url":151,"label":120},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AH02",{"kind":153,"url":136,"label":8},"darooyab",{"pregnancy":155,"lactation":164,"pediatric":172,"geriatric":180},{"level":156,"text":157,"quote":160,"refs":161},"caution",{"fa":158,"en":159},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates exposed to antipsychotic drugs, including clozapine, during the third trimester are at risk for extrapyramidal and\u002For withdrawal symptoms following delivery ( see Clinical Considerations ).",[162],{"source":33,"section":163},"8.1",{"level":156,"text":165,"quote":168,"refs":169},{"fa":166,"en":167},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Clozapine is present in human milk.",[170],{"source":33,"section":171},"8.2",{"level":173,"text":174,"quote":177,"refs":178},"not-established",{"fa":175,"en":176},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[179],{"source":33,"section":103},{"level":181,"text":182,"quote":185,"refs":186},"avoid",{"fa":183,"en":184},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","Increased Mortality in Elderly Patients with Dementia-Related Psychosis Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.",[187],{"source":33,"section":93},{"kind":189,"refs":190,"id":141},"ANDA",[191],{"source":33,"section":192},"SPL approval \u002F marketing category",1792191877098]