[{"data":1,"prerenderedAt":211},["ShallowReactive",2],{"drug-cyclobenzaprine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":113,"warnings":133,"renal":134,"monitoring":135,"interactions":136,"review":137,"examples":140,"atc":152,"iran":154,"links":161,"populations":181,"usApproval":206},"cyclobenzaprine",1,{"fa":7,"en":8},"سیکلوبنزاپرین","Cyclobenzaprine","musculoskeletal",{"fa":11,"en":12},"شل‌کننده عضلانی","Skeletal muscle relaxant",[14],{"name":15,"market":16},"Flexeril","US",[18,19,7,20],"flexeril","فلکسریل","شل کننده عضله",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-5","tablet","oral","5 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},5,"mg",false,[16],[33],{"source":34,"section":35},"fda-cyclobenzaprine2","How Supplied",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-7-5","7.5 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},7.5,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-10","10 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},10,[16],[51],{"source":34,"section":35},[53,79,96],{"id":54,"disease":55,"label":56,"population":59,"type":63,"unit":29,"dose":64,"refs":66,"durationDays":69,"notes":72},"spasm","muscle-spasm",{"fa":57,"en":58},"اسپاسم عضلانی حاد — ۵ mg سه بار در روز","Acute muscle spasm — 5 mg three times daily",{"minAge":60},{"value":61,"unit":62},15,"year","fixed",{"perDose":28,"perDoseMax":48,"dosesPerDay":65},3,[67],{"source":34,"section":68},"Dosage and Administration",{"min":70,"max":71},14,21,[73],{"text":74,"refs":77},{"fa":75,"en":76},"در صورت نیاز ۱۰ mg سه بار. بیش از ۲ تا ۳ هفته توصیه نمی‌شود.","If needed 10 mg three times daily. Use beyond 2–3 weeks not recommended.",[78],{"source":34,"section":68},{"id":80,"disease":81,"label":82,"population":85,"type":63,"unit":29,"dose":87,"refs":88,"durationDays":90,"notes":91},"back","low-back-pain",{"fa":83,"en":84},"کمردرد حاد با اسپاسم عضلانی — کوتاه‌مدت (۲ تا ۳ هفته)","Acute low back pain with muscle spasm — short term (2–3 weeks)",{"minAge":86},{"value":61,"unit":62},{"perDose":28,"perDoseMax":48,"dosesPerDay":65},[89],{"source":34,"section":68},{"min":70,"max":71},[92],{"text":93,"refs":94},{"fa":75,"en":76},[95],{"source":34,"section":68},{"id":97,"disease":98,"label":99,"population":102,"type":63,"unit":29,"dose":104,"refs":105,"durationDays":107,"notes":108},"strain","muscle-strain",{"fa":100,"en":101},"کشیدگی یا پیچ‌خوردگی با اسپاسم عضلانی — کوتاه‌مدت","Strain or sprain with muscle spasm — short term",{"minAge":103},{"value":61,"unit":62},{"perDose":28,"perDoseMax":48,"dosesPerDay":65},[106],{"source":34,"section":68},{"min":70,"max":71},[109],{"text":110,"refs":111},{"fa":75,"en":76},[112],{"source":34,"section":68},[114,123],{"id":115,"severity":116,"text":117,"refs":120},"ci","block",{"fa":118,"en":119},"حساسیت؛ همراه یا تا ۱۴ روز پس از MAOI؛ فاز بهبود حاد MI؛ آریتمی، بلوک یا اختلال هدایت؛ نارسایی قلبی؛ پرکاری تیروئید.","Hypersensitivity; with or within 14 days of an MAOI; acute recovery phase of MI; arrhythmias, heart block or conduction disturbances; heart failure; hyperthyroidism.",[121],{"source":34,"section":122},"Contraindications",{"id":124,"severity":116,"rule":125,"text":127,"refs":130},"under-15",{"maxAge":126},{"value":61,"unit":62},{"fa":128,"en":129},"زیر ۱۵ سال ثابت نشده.","Not established under 15 years.",[131],{"source":34,"section":132},"Pediatric Use",[],[],[],[],{"status":138,"reviewer":139,"date":139},"unverified",null,[141,146,149],{"regimen":54,"formulation":23,"input":142,"expect":145},{"ageYears":143,"weightKg":144},30,70,{"perDose":28,"upperPerDose":48},{"regimen":80,"formulation":23,"input":147,"expect":148},{"ageYears":143,"weightKg":144},{"perDose":28,"upperPerDose":48},{"regimen":97,"formulation":23,"input":150,"expect":151},{"ageYears":143,"weightKg":144},{"perDose":28,"upperPerDose":48},[153],"M03BX08",{"status":155,"refs":156},"not-found",[157],{"source":158,"section":159,"url":160},"darooyab-generic","G-2790\u002FCyclobenzaprine","https:\u002F\u002Fwww.darooyab.ir\u002FG-2790\u002FCyclobenzaprine",[162,166,170,173,176,179],{"kind":163,"url":164,"label":165},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=213324","ANDA213324",{"kind":167,"url":168,"label":169},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=71185d15-3fd7-42b7-83a6-8357e3aaef43","FDA Cyclobenzaprine",{"kind":171,"url":172,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682514.html",{"kind":171,"url":174,"label":175},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa625112.html","Cyclobenzaprine Sublingual",{"kind":177,"url":178,"label":153},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M03BX08",{"kind":180,"url":160,"label":8},"darooyab",{"pregnancy":182,"lactation":191,"pediatric":199},{"level":183,"text":184,"quote":187,"refs":188},"caution",{"fa":185,"en":186},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Pregnancy Category B: Reproduction studies have been performed in rats, mice and rabbits atdoses up to 20 times the human dose, and have revealed no evidence of impaired fertility or harm to the fetus due to cyclobenzaprine hydrochloride.",[189],{"source":34,"section":190},"Pregnancy",{"level":183,"text":192,"quote":195,"refs":196},{"fa":193,"en":194},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because cyclobenzaprine is closely related to the tricyclic antidepressants, some of which are known to be excreted in human milk, caution should be exercised when cyclobenzaprine hydrochloride is administered to a nursing woman.",[197],{"source":34,"section":198},"Nursing Mothers",{"level":183,"text":200,"quote":203,"refs":204},{"fa":201,"en":202},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness of cyclobenzaprine hydrochloride in pediatric patients below 15 years of age have not been established.",[205],{"source":34,"section":132},{"kind":207,"refs":208,"id":165},"ANDA",[209],{"source":34,"section":210},"SPL approval \u002F marketing category",1792191875734]