[{"data":1,"prerenderedAt":233},["ShallowReactive",2],{"drug-diltiazem":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":60,"contraindications":98,"warnings":108,"renal":109,"monitoring":110,"interactions":111,"review":112,"examples":115,"atc":120,"iran":122,"links":177,"populations":194,"usApproval":228},"diltiazem",1,{"fa":7,"en":8},"دیلتیازم","Diltiazem","cardiovascular",{"fa":11,"en":12},"مسدودکننده کانال کلسیم","Calcium-channel blocker",[14],{"name":15,"market":16},"Cardizem","US",[18,19,7],"cardizem","کاردیزم",[21,35,44,52],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-30","tablet","oral","30 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},30,"mg",false,[16],[32],{"source":33,"section":34},"fda-diltiazemir","How Supplied",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":41,"refs":42},"tab-60","60 mg tablet (scored)",{"amount":39,"unit":28,"perUnit":23,"scored":40},60,true,[16],[43],{"source":33,"section":34},{"id":45,"form":23,"route":24,"label":46,"concentration":47,"markets":49,"refs":50},"tab-90","90 mg tablet (scored)",{"amount":48,"unit":28,"perUnit":23,"scored":40},90,[16],[51],{"source":33,"section":34},{"id":53,"form":23,"route":24,"label":54,"concentration":55,"markets":57,"refs":58},"tab-120","120 mg tablet (scored)",{"amount":56,"unit":28,"perUnit":23,"scored":40},120,[16],[59],{"source":33,"section":34},[61,83],{"id":62,"disease":62,"label":63,"population":66,"type":70,"unit":28,"dose":71,"refs":73,"notes":76},"angina",{"fa":64,"en":65},"آنژین — شروع ۳۰ mg چهار بار در روز","Angina — start 30 mg four times daily",{"minAge":67},{"value":68,"unit":69},18,"year","fixed",{"perDose":27,"dosesPerDay":72},4,[74],{"source":33,"section":75},"Dosage and Administration",[77],{"text":78,"refs":81},{"fa":79,"en":80},"قبل از غذا و هنگام خواب؛ افزایش تدریجی هر ۱ تا ۲ روز؛ محدوده بهینه ۱۸۰ تا ۳۶۰ mg\u002Fday در ۳ یا ۴ نوبت. قرص ۳۰ mg نصف نشود.","Before meals and at bedtime; increase every 1–2 days; optimum 180–360 mg\u002Fday in 3–4 doses. Do not split 30 mg tablets.",[82],{"source":33,"section":75},{"id":84,"disease":62,"label":85,"population":88,"type":90,"unit":28,"dose":91,"refs":95},"peds",{"fa":86,"en":87},"زیر ۱۸ سال","Under 18 years",{"maxAge":89},{"value":68,"unit":69},"notCalculated",{"reason":92},{"fa":93,"en":94},"بی‌خطری و اثربخشی در کودکان ثابت نشده است.","Safety and effectiveness in children not established.",[96],{"source":33,"section":97},"Pediatric Use",[99],{"id":100,"severity":101,"text":102,"refs":105},"ci","block",{"fa":103,"en":104},"سندرم سینوس بیمار یا بلوک AV درجه ۲ یا ۳ (بدون پیس‌میکر)؛ افت فشار (سیستولیک \u003C۹۰)؛ MI حاد با احتقان ریه؛ حساسیت.","Sick sinus syndrome or second\u002Fthird-degree AV block (no pacemaker); hypotension (\u003C90 systolic); acute MI with pulmonary congestion; hypersensitivity.",[106],{"source":33,"section":107},"Contraindications",[],[],[],[],{"status":113,"reviewer":114,"date":114},"unverified",null,[116],{"regimen":62,"formulation":22,"input":117,"expect":119},{"ageYears":39,"weightKg":118},80,{"perDose":27,"perDay":56},[121],"C08DB01",{"status":123,"forms":124,"refs":172},"registered",[125,129,133,137,141,145,149,153,157,161,165,169],{"code":126,"en":127,"fa":128},"19431","DILTIAZEM 2% GEL","ژل دیلتیازم ۲ درصد",{"code":130,"en":131,"fa":132},"01470","DILTIAZEM HCL 100MG AMP","آمپول دیلتیازم هیدروکلراید ۱۰۰ میلی‌گرم",{"code":134,"en":135,"fa":136},"01471","DILTIAZEM HCL 100MG VIAL","ویال دیلتیازم هیدروکلراید ۱۰۰ میلی‌گرم",{"code":138,"en":139,"fa":140},"01467","DILTIAZEM HCL 10MG VIAL","ویال دیلتیازم هیدروکلراید ۱۰ میلی‌گرم",{"code":142,"en":143,"fa":144},"01468","DILTIAZEM HCL 25MG VIAL","ویال دیلتیازم هیدروکلراید ۲۵ میلی‌گرم",{"code":146,"en":147,"fa":148},"00447","DILTIAZEM HCL 60MG TAB","قرص دیلتیازم هیدروکلراید ۶۰ میلی‌گرم",{"code":150,"en":151,"fa":152},"01469","DILTIAZEM HCL 90MG TAB","قرص دیلتیازم هیدروکلراید ۹۰ میلی‌گرم",{"code":154,"en":155,"fa":156},"02204","DILTIAZEM HCL SR 120MG CAP","کپسول آهسته‌رهش دیلتیازم هیدروکلراید ۱۲۰ میلی‌گرم",{"code":158,"en":159,"fa":160},"01472","DILTIAZEM HCL SR 120MG TAB","قرص آهسته‌رهش دیلتیازم هیدروکلراید ۱۲۰ میلی‌گرم",{"code":162,"en":163,"fa":164},"14507","DILTIAZEM HCL SR 180MG CAP","کپسول آهسته‌رهش دیلتیازم هیدروکلراید ۱۸۰ میلی‌گرم",{"code":166,"en":167,"fa":168},"52455","DILTIAZEM HYDROCHLORIDE TABLET ORAL 30 mg","قرص دیلتیازم هیدروکلراید ۳۰ میلی‌گرم",{"code":170,"en":171,"fa":152},"52456","DILTIAZEM HYDROCHLORIDE TABLET ORAL 90 mg",[173],{"source":174,"section":175,"url":176},"darooyab-generic","G-1642\u002FDiltiazem","https:\u002F\u002Fwww.darooyab.ir\u002FG-1642\u002FDiltiazem",[178,182,186,189,192],{"kind":179,"url":180,"label":181},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=219253","ANDA219253",{"kind":183,"url":184,"label":185},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=43cffe12-304a-4e15-9512-94f812188f1a","FDA Diltiazem",{"kind":187,"url":188,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa684027.html",{"kind":190,"url":191,"label":121},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C08DB01",{"kind":193,"url":176,"label":8},"darooyab",{"pregnancy":195,"lactation":204,"pediatric":212,"geriatric":220},{"level":196,"text":197,"quote":200,"refs":201},"caution",{"fa":198,"en":199},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Reproduction studies have been conducted in mice, rats, and rabbits.",[202],{"source":33,"section":203},"Pregnancy",{"level":196,"text":205,"quote":208,"refs":209},{"fa":206,"en":207},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Diltiazem is excreted in human milk.",[210],{"source":33,"section":211},"Nursing Mothers",{"level":213,"text":214,"quote":217,"refs":218},"not-established",{"fa":215,"en":216},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[219],{"source":33,"section":97},{"level":196,"text":221,"quote":224,"refs":225},{"fa":222,"en":223},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[226],{"source":33,"section":227},"Geriatric Use",{"kind":229,"refs":230,"id":181},"ANDA",[231],{"source":33,"section":232},"SPL approval \u002F marketing category",1792191868758]