[{"data":1,"prerenderedAt":285},["ShallowReactive",2],{"drug-esomeprazole":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":44,"contraindications":140,"warnings":150,"renal":151,"monitoring":152,"interactions":153,"review":154,"examples":157,"atc":180,"iran":182,"links":226,"populations":246,"usApproval":280},"esomeprazole",1,{"fa":7,"en":8},"ازومپرازول","Esomeprazole","alimentary-metabolism",{"fa":11,"en":12},"مهارکننده پمپ پروتون","Proton-pump inhibitor",[14],{"name":15,"market":16},"Nexium","US",[18,19,7,20],"nexium","نکسیوم","PPI",[22,36],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"cap-20","capsule","oral","20 mg capsule",{"amount":28,"unit":29,"perUnit":24,"scored":30},20,"mg",false,[16],[33],{"source":34,"section":35},"fda-nexium","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"cap-40","40 mg capsule",{"amount":40,"unit":29,"perUnit":24,"scored":30},40,[16],[43],{"source":34,"section":35},[45,72,83,103,114,128],{"id":46,"disease":47,"label":48,"population":51,"type":55,"unit":29,"dose":56,"refs":57,"durationDays":60,"notes":63},"ee","erosive-esophagitis",{"fa":49,"en":50},"ازوفاژیت اروزیو — ۲۰ یا ۴۰ mg یک بار، ۴ تا ۸ هفته","Erosive oesophagitis — 20 or 40 mg once daily for 4–8 weeks",{"minAge":52},{"value":53,"unit":54},18,"year","fixed",{"perDose":28,"perDoseMax":40,"dosesPerDay":5},[58],{"source":34,"section":59},"2.1, Table 1",{"min":61,"max":62},28,56,[64],{"text":65,"refs":68},{"fa":66,"en":67},"حداقل یک ساعت قبل از غذا؛ کامل بلعیده شود. نارسایی شدید کبد: حداکثر ۲۰ mg. نگهدارنده: ۲۰ mg روزانه.","At least 1 h before meals; swallow whole. Severe liver impairment: max 20 mg. Maintenance: 20 mg daily.",[69,70],{"source":34,"section":59},{"source":34,"section":71},"2.3",{"id":73,"disease":73,"label":74,"population":77,"type":55,"unit":29,"dose":79,"refs":80,"durationDays":82},"gerd",{"fa":75,"en":76},"GERD علامت‌دار — ۲۰ mg یک بار، ۴ هفته","Symptomatic GERD — 20 mg once daily for 4 weeks",{"minAge":78},{"value":53,"unit":54},{"perDose":28,"dosesPerDay":5},[81],{"source":34,"section":59},{"min":61,"max":61},{"id":84,"disease":85,"label":86,"population":89,"type":55,"unit":29,"dose":91,"refs":92,"durationDays":94,"notes":96},"hp","h-pylori",{"fa":87,"en":88},"ریشه‌کنی H. pylori (سه‌دارویی) — ۴۰ mg یک بار، ۱۰ روز","H. pylori eradication (triple therapy) — 40 mg once daily for 10 days",{"minAge":90},{"value":53,"unit":54},{"perDose":40,"dosesPerDay":5},[93],{"source":34,"section":59},{"min":95,"max":95},10,[97],{"text":98,"refs":101},{"fa":99,"en":100},"همراه آموکسی‌سیلین ۱۰۰۰ mg دو بار و کلاریترومایسین ۵۰۰ mg دو بار، ۱۰ روز.","With amoxicillin 1,000 mg twice daily and clarithromycin 500 mg twice daily for 10 days.",[102],{"source":34,"section":59},{"id":104,"disease":105,"label":106,"population":109,"type":55,"unit":29,"dose":111,"refs":112},"nsaid","peptic-ulcer-disease",{"fa":107,"en":108},"کاهش خطر زخم معده ناشی از NSAID — ۲۰ یا ۴۰ mg یک بار","NSAID gastric-ulcer risk reduction — 20 or 40 mg once daily",{"minAge":110},{"value":53,"unit":54},{"perDose":28,"perDoseMax":40,"dosesPerDay":5},[113],{"source":34,"section":59},{"id":115,"disease":73,"label":116,"population":119,"type":55,"unit":29,"dose":123,"refs":124,"durationDays":127},"peds-gerd",{"fa":117,"en":118},"GERD علامت‌دار — ۱۲ تا ۱۷ سال: ۲۰ mg یک بار، ۴ هفته","Symptomatic GERD — 12–17 y: 20 mg once daily for 4 weeks",{"minAge":120,"maxAge":122},{"value":121,"unit":54},12,{"value":53,"unit":54},{"perDose":28,"dosesPerDay":5},[125],{"source":34,"section":126},"2.2, Table 2",{"min":61,"max":61},{"id":129,"disease":47,"label":130,"population":133,"type":55,"unit":29,"dose":136,"refs":137,"durationDays":139},"peds-ee",{"fa":131,"en":132},"ازوفاژیت اروزیو — ۱۲ تا ۱۷ سال: ۲۰ یا ۴۰ mg یک بار، ۴ تا ۸ هفته","Erosive oesophagitis — 12–17 y: 20 or 40 mg once daily, 4–8 weeks",{"minAge":134,"maxAge":135},{"value":121,"unit":54},{"value":53,"unit":54},{"perDose":28,"perDoseMax":40,"dosesPerDay":5},[138],{"source":34,"section":126},{"min":61,"max":62},[141],{"id":142,"severity":143,"text":144,"refs":147},"ci","block",{"fa":145,"en":146},"حساسیت به بنزیمیدازول‌های جایگزین‌شده (آنافیلاکسی، آنژیوادم، نفریت بینابینی).","Hypersensitivity to substituted benzimidazoles (anaphylaxis, angioedema, interstitial nephritis).",[148],{"source":34,"section":149},"4",[],[],[],[],{"status":155,"reviewer":156,"date":156},"unverified",null,[158,162,165,168,172,177],{"regimen":46,"formulation":23,"input":159,"expect":161},{"ageYears":40,"weightKg":160},70,{"perDose":28,"upperPerDose":40},{"regimen":73,"formulation":23,"input":163,"expect":164},{"ageYears":40,"weightKg":160},{"perDose":28},{"regimen":84,"formulation":37,"input":166,"expect":167},{"ageYears":40,"weightKg":160},{"perDose":40},{"regimen":104,"formulation":23,"input":169,"expect":171},{"ageYears":170,"weightKg":160},60,{"perDose":28},{"regimen":115,"formulation":23,"input":173,"expect":176},{"ageYears":174,"weightKg":175},14,50,{"perDose":28},{"regimen":129,"formulation":23,"input":178,"expect":179},{"ageYears":174,"weightKg":175},{"perDose":28},[181],"A02BC05",{"status":183,"forms":184,"refs":221},"registered",[185,189,193,197,201,205,209,213,217],{"code":186,"en":187,"fa":188},"18013","ESOMEPRAZOLE 10 MG  GRANULE","گرانول ازومپرازول ۱۰ میلی‌گرم",{"code":190,"en":191,"fa":192},"16306","ESOMEPRAZOLE 10MG SACHET","ساشه ازومپرازول ۱۰ میلی‌گرم",{"code":194,"en":195,"fa":196},"13973","ESOMEPRAZOLE 20MG CAP","کپسول ازومپرازول ۲۰ میلی‌گرم",{"code":198,"en":199,"fa":200},"05922","ESOMEPRAZOLE 20MG TAB","قرص ازومپرازول ۲۰ میلی‌گرم",{"code":202,"en":203,"fa":204},"13974","ESOMEPRAZOLE 40MG CAP","کپسول ازومپرازول ۴۰ میلی‌گرم",{"code":206,"en":207,"fa":208},"05923","ESOMEPRAZOLE 40MG TAB","قرص ازومپرازول ۴۰ میلی‌گرم",{"code":210,"en":211,"fa":212},"52188","ESOMEPRAZOLE 5 MG GRANULE","گرانول ازومپرازول ۵ میلی‌گرم",{"code":214,"en":215,"fa":216},"52675","ESOMEPRAZOLE 2.5 MG GRANULE","گرانول ازومپرازول ۲٫۵ میلی‌گرم",{"code":218,"en":219,"fa":220},"52085","ESOMEPRAZOLE (AS MAGNESIUM) GRANULE, DELAYED RELEASE ORAL 10 mg","گرانول ازومپرازول (معادل منیزیم) ۱۰ میلی‌گرم",[222],{"source":223,"section":224,"url":225},"darooyab-generic","G-2582\u002FEsomeprazole","https:\u002F\u002Fwww.darooyab.ir\u002FG-2582\u002FEsomeprazole",[227,231,235,238,241,244],{"kind":228,"url":229,"label":230},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021153","NDA021153",{"kind":232,"url":233,"label":234},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f4853677-1622-4037-688b-fdf533a11d96","FDA Nexium",{"kind":236,"url":237,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699054.html",{"kind":236,"url":239,"label":240},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa619032.html","Esomeprazole Injection",{"kind":242,"url":243,"label":181},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A02BC05",{"kind":245,"url":225,"label":8},"darooyab",{"pregnancy":247,"lactation":256,"pediatric":264,"geriatric":272},{"level":248,"text":249,"quote":252,"refs":253},"caution",{"fa":250,"en":251},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are no adequate and well-controlled studies with esomeprazole in pregnant women.",[254],{"source":34,"section":255},"8.1",{"level":248,"text":257,"quote":260,"refs":261},{"fa":258,"en":259},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Esomeprazole is the S-isomer of omeprazole and limited data suggest that omeprazole may be present in human milk.",[262],{"source":34,"section":263},"8.2",{"level":248,"text":265,"quote":268,"refs":269},{"fa":266,"en":267},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Healing of EE Pediatric Patients 1 Year to 17 Years of Age The safety and effectiveness of NEXIUM delayed-release capsules and NEXIUM for delayed-release oral suspension have been established in pediatric patients 12 years to 17 years for short-term treatment (4 to 8 weeks) for healing of EE.",[270],{"source":34,"section":271},"8.4",{"level":248,"text":273,"quote":276,"refs":277},{"fa":274,"en":275},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the total number of patients who received NEXIUM in clinical trials, 1459 were 65 to 74 years of age and 354 patients were 75 years of age and older.",[278],{"source":34,"section":279},"8.5",{"kind":281,"refs":282,"id":230},"NDA",[283],{"source":34,"section":284},"SPL approval \u002F marketing category",1792440719914]