[{"data":1,"prerenderedAt":162},["ShallowReactive",2],{"drug-ezetimibe":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":36,"contraindications":60,"warnings":79,"renal":80,"monitoring":81,"interactions":82,"review":83,"examples":86,"atc":92,"iran":94,"links":106,"populations":123,"usApproval":157},"ezetimibe",1,{"fa":7,"en":8},"ازتیمایب","Ezetimibe","cardiovascular",{"fa":11,"en":12},"مهارکننده جذب کلسترول","Cholesterol absorption inhibitor",[14],{"name":15,"market":16},"Zetia","US",[18,19,20,7],"zetia","زتیا","ازتیمیب",[22],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-10","tablet","oral","10 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},10,"mg",false,[16],[33],{"source":34,"section":35},"fda-ezetimibe","3",[37],{"id":38,"disease":39,"label":40,"population":43,"type":46,"unit":29,"dose":47,"refs":48,"notes":51},"adult","hyperlipidemia",{"fa":41,"en":42},"چربی خون — ۱۰ mg یک بار در روز","Hyperlipidaemia — 10 mg once daily",{"minAge":44},{"value":28,"unit":45},"year","fixed",{"perDose":28,"dosesPerDay":5},[49],{"source":34,"section":50},"2",[52],{"text":53,"refs":56},{"fa":54,"en":55},"با یا بدون غذا؛ ۲ ساعت قبل یا ۴ ساعت بعد از رزین‌های اسید صفراوی. کودکان ۱۰ سال به بالا: فقط FH هتروزیگوت همراه استاتین.","With or without food; 2 h before or 4 h after bile acid sequestrants. Children ≥10 y: HeFH only, with a statin.",[57,58],{"source":34,"section":50},{"source":34,"section":59},"8.4",[61,70],{"id":62,"severity":63,"text":64,"refs":67},"ci","block",{"fa":65,"en":66},"حساسیت؛ در ترکیب با استاتین یا فنوفیبرات، هر جا آن‌ها منع دارند.","Hypersensitivity; with a statin or fenofibrate, wherever those are contraindicated.",[68],{"source":34,"section":69},"4",{"id":71,"severity":63,"rule":72,"text":74,"refs":77},"under-10",{"maxAge":73},{"value":28,"unit":45},{"fa":75,"en":76},"زیر ۱۰ سال ثابت نشده.","Not established under 10 years.",[78],{"source":34,"section":59},[],[],[],[],{"status":84,"reviewer":85,"date":85},"unverified",null,[87],{"regimen":38,"formulation":23,"input":88,"expect":91},{"ageYears":89,"weightKg":90},55,80,{"perDose":28},[93],"C10AX09",{"status":95,"forms":96,"refs":101},"registered",[97],{"code":98,"en":99,"fa":100},"05657","EZETIMIBE 10MG TAB","قرص ازتیمایب ۱۰ میلی‌گرم",[102],{"source":103,"section":104,"url":105},"darooyab-generic","G-1676\u002FEzetimibe","https:\u002F\u002Fwww.darooyab.ir\u002FG-1676\u002FEzetimibe",[107,111,115,118,121],{"kind":108,"url":109,"label":110},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=208803","ANDA208803",{"kind":112,"url":113,"label":114},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=6fcbfbd9-6e09-8224-e053-2a91aa0a8226","FDA Ezetimibe",{"kind":116,"url":117,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa603015.html",{"kind":119,"url":120,"label":93},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C10AX09",{"kind":122,"url":105,"label":8},"darooyab",{"pregnancy":124,"lactation":133,"pediatric":141,"geriatric":148},{"level":125,"text":126,"quote":129,"refs":130},"caution",{"fa":127,"en":128},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary There are insufficient data on ezetimibe use in pregnant women to evaluate for a drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.",[131],{"source":34,"section":132},"8.1",{"level":125,"text":134,"quote":137,"refs":138},{"fa":135,"en":136},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There is no information about the presence of ezetimibe in human milk.",[139],{"source":34,"section":140},"8.2",{"level":125,"text":142,"quote":145,"refs":146},{"fa":143,"en":144},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of ezetimibe in combination with a statin as an adjunct to diet to reduce LDL-C have been established in pediatric patients 10 years of age and older with HeFH.",[147],{"source":34,"section":59},{"level":149,"text":150,"quote":153,"refs":154},"ok",{"fa":151,"en":152},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in safety or effectiveness of ezetimibe have been observed between patients 65 years of age and older and younger patients.",[155],{"source":34,"section":156},"8.5",{"kind":158,"refs":159,"id":110},"ANDA",[160],{"source":34,"section":161},"SPL approval \u002F marketing category",1792191868982]