[{"data":1,"prerenderedAt":263},["ShallowReactive",2],{"drug-imipramine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":54,"contraindications":128,"warnings":159,"renal":160,"monitoring":161,"interactions":162,"review":163,"examples":166,"atc":181,"iran":183,"links":207,"populations":224,"usApproval":258},"imipramine",1,{"fa":7,"en":8},"ایمی‌پرامین","Imipramine","nervous-system",{"fa":11,"en":12},"ضدافسردگی سه‌حلقه‌ای","Tricyclic antidepressant",[14],{"name":15,"market":16},"Tofranil","US",[18,19,20,21,22],"tofranil","توفرانیل","ایمی پرامین","ایمیپرامین","شب ادراری",[24,38,46],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"tab-10","tablet","oral","10 mg tablet",{"amount":30,"unit":31,"perUnit":26,"scored":32},10,"mg",false,[16],[35],{"source":36,"section":37},"fda-imipramine","How Supplied",{"id":39,"form":26,"route":27,"label":40,"concentration":41,"markets":43,"refs":44},"tab-25","25 mg tablet",{"amount":42,"unit":31,"perUnit":26,"scored":32},25,[16],[45],{"source":36,"section":37},{"id":47,"form":26,"route":27,"label":48,"concentration":49,"markets":51,"refs":52},"tab-50","50 mg tablet",{"amount":50,"unit":31,"perUnit":26,"scored":32},50,[16],[53],{"source":36,"section":37},[55,81,106],{"id":56,"disease":56,"label":57,"population":60,"type":64,"unit":31,"dose":65,"refs":67,"limits":70,"notes":74},"mdd",{"fa":58,"en":59},"افسردگی — بزرگسال سرپایی: ۷۵ mg\u002Fday (تا ۱۵۰)","Depression — adult outpatients: 75 mg\u002Fday (up to 150)",{"minAge":61},{"value":62,"unit":63},18,"year","fixed",{"perDose":42,"dosesPerDay":66},3,[68],{"source":36,"section":69},"Dosage and Administration",{"maxPerDay":71,"refs":72},200,[73],{"source":36,"section":69},[75],{"text":76,"refs":79},{"fa":77,"en":78},"بستری: ۱۰۰ mg\u002Fday تا ۲۰۰؛ بالای ۲۰۰ mg\u002Fday توصیه نمی‌شود (جز بستری‌های مقاوم). نگهدارنده ۵۰ تا ۱۵۰ mg\u002Fday.","Inpatients: 100 mg\u002Fday up to 200; over 200 mg\u002Fday not recommended (except resistant inpatients). Maintenance 50–150 mg\u002Fday.",[80],{"source":36,"section":69},{"id":82,"disease":83,"label":84,"population":87,"type":64,"unit":31,"dose":92,"refs":93,"limits":95,"notes":99},"enuresis-6-11","nocturnal-enuresis",{"fa":85,"en":86},"شب‌ادراری — ۶ تا ۱۱ سال: ۲۵ mg یک ساعت قبل از خواب","Enuresis — 6–11 y: 25 mg one hour before bedtime",{"minAge":88,"maxAge":90},{"value":89,"unit":63},6,{"value":91,"unit":63},12,{"perDose":42,"dosesPerDay":5},[94],{"source":36,"section":69},{"maxPerKgPerDay":96,"refs":97},2.5,[98],{"source":36,"section":69},[100],{"text":101,"refs":104},{"fa":102,"en":103},"اگر پس از یک هفته پاسخ نبود ۵۰ mg شبانه. بیش از ۲٫۵ mg\u002Fkg\u002Fday نشود.","If no response after one week, 50 mg nightly. Do not exceed 2.5 mg\u002Fkg\u002Fday.",[105],{"source":36,"section":69},{"id":107,"disease":83,"label":108,"population":111,"type":64,"unit":31,"dose":114,"refs":115,"limits":117,"notes":121},"enuresis-12",{"fa":109,"en":110},"شب‌ادراری — ۱۲ سال به بالا: ۲۵ mg قبل از خواب","Enuresis — ≥12 y: 25 mg before bedtime",{"minAge":112,"maxAge":113},{"value":91,"unit":63},{"value":62,"unit":63},{"perDose":42,"dosesPerDay":5},[116],{"source":36,"section":69},{"maxPerKgPerDay":96,"maxPerDay":118,"refs":119},75,[120],{"source":36,"section":69},[122],{"text":123,"refs":126},{"fa":124,"en":125},"در صورت نیاز تا ۷۵ mg شبانه؛ بالاتر اثر بیشتری ندارد.","Up to 75 mg nightly if needed; higher adds no efficacy.",[127],{"source":36,"section":69},[129,138,148],{"id":130,"severity":131,"text":132,"refs":135},"ci","block",{"fa":133,"en":134},"همراه MAOI؛ دوره بهبود حاد پس از MI.","With MAOIs; acute recovery period after MI.",[136],{"source":36,"section":137},"Contraindications",{"id":139,"severity":131,"rule":140,"text":142,"refs":145},"under-6",{"maxAge":141},{"value":89,"unit":63},{"fa":143,"en":144},"زیر ۶ سال ثابت نشده.","Not established under 6 years.",[146],{"source":36,"section":147},"Pediatric Use",{"id":149,"severity":150,"rule":151,"text":153,"refs":156},"suicide","warn",{"maxAge":152},{"value":42,"unit":63},{"fa":154,"en":155},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان، نوجوانان و جوانان.","Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults.",[157],{"source":36,"section":158},"Boxed Warning",[],[],[],[],{"status":164,"reviewer":165,"date":165},"unverified",null,[167,172,176],{"regimen":56,"formulation":39,"input":168,"expect":171},{"ageYears":169,"weightKg":170},40,70,{"perDose":42,"perDay":118},{"regimen":82,"formulation":39,"input":173,"expect":175},{"ageYears":174,"weightKg":42},8,{"perDose":42},{"regimen":107,"formulation":39,"input":177,"expect":180},{"ageYears":178,"weightKg":179},13,45,{"perDose":42},[182],"N06AA02",{"status":184,"forms":185,"refs":202},"registered",[186,190,194,198],{"code":187,"en":188,"fa":189},"00664","IMIPRAMINE HCL 10MG TAB","قرص ایمی‌پرامین هیدروکلراید ۱۰ میلی‌گرم",{"code":191,"en":192,"fa":193},"00665","IMIPRAMINE HCL 25MG TAB","قرص ایمی‌پرامین هیدروکلراید ۲۵ میلی‌گرم",{"code":195,"en":196,"fa":197},"00663","IMIPRAMINE HCL 25MG\u002F2ML AMP","آمپول ایمی‌پرامین هیدروکلراید ۲۵ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":199,"en":200,"fa":201},"00666","IMIPRAMINE HCL 50MG TAB","قرص ایمی‌پرامین هیدروکلراید ۵۰ میلی‌گرم",[203],{"source":204,"section":205,"url":206},"darooyab-generic","G-588\u002FImipramine","https:\u002F\u002Fwww.darooyab.ir\u002FG-588\u002FImipramine",[208,212,216,219,222],{"kind":209,"url":210,"label":211},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040903","ANDA040903",{"kind":213,"url":214,"label":215},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=490263ce-b4d2-428a-87da-fcd07f85499a","FDA Imipramine",{"kind":217,"url":218,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682389.html",{"kind":220,"url":221,"label":182},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06AA02",{"kind":223,"url":206,"label":8},"darooyab",{"pregnancy":225,"lactation":234,"pediatric":242,"geriatric":250},{"level":226,"text":227,"quote":230,"refs":231},"caution",{"fa":228,"en":229},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Animal reproduction studies have yielded inconclusive results (see also ANIMAL PHARMACOLOGY & TOXICOLOGY ).",[232],{"source":36,"section":233},"Pregnancy",{"level":226,"text":235,"quote":238,"refs":239},{"fa":236,"en":237},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Limited data suggest that imipramine hydrochloride tablets, is likely to be excreted in human breast milk.",[240],{"source":36,"section":241},"Nursing Mothers",{"level":243,"text":244,"quote":247,"refs":248},"avoid",{"fa":245,"en":246},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Imipramine hydrochloride is not approved for use in pediatric patients (see WARNINGS: Clinical Worsening and Suicide Risk , PRECAUTIONS, Information for Patients , and PRECAUTIONS: Pediatric Use ).",[249],{"source":36,"section":158},{"level":226,"text":251,"quote":254,"refs":255},{"fa":252,"en":253},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for the elderly should be cautious, usually starting at the low end of the dosing range, reflecting greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[256],{"source":36,"section":257},"Geriatric Use",{"kind":259,"refs":260,"id":211},"ANDA",[261],{"source":36,"section":262},"SPL approval \u002F marketing category",1792440737562]