[{"data":1,"prerenderedAt":229},["ShallowReactive",2],{"drug-labetalol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":62,"contraindications":109,"warnings":126,"renal":127,"monitoring":128,"interactions":129,"review":130,"examples":133,"atc":143,"iran":145,"links":177,"populations":197,"usApproval":224},"labetalol",1,{"fa":7,"en":8},"لابتالول","Labetalol","cardiovascular",{"fa":11,"en":12},"بتابلاکر با اثر آلفا","Alpha\u002Fbeta blocker",[14],{"name":15,"market":16},"Trandate","US",[18,7,19],"trandate","ترانديت",[21,35,43,51],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-100","tablet","oral","100 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},100,"mg",true,[16],[32],{"source":33,"section":34},"fda-labetalol","How Supplied",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-200","200 mg tablet (scored)",{"amount":39,"unit":28,"perUnit":23,"scored":29},200,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"tab-300","300 mg tablet (scored)",{"amount":47,"unit":28,"perUnit":23,"scored":29},300,[16],[50],{"source":33,"section":34},{"id":52,"form":53,"route":54,"label":55,"concentration":56,"markets":58,"refs":59},"inj-5","injection","iv","5 mg\u002FmL injection (20 or 40 mL vial)",{"amount":57,"unit":28,"perVolumeMl":5},5,[16],[60],{"source":61,"section":34},"fda-labetalol-inj",[63,87],{"id":64,"disease":65,"label":66,"population":69,"type":73,"unit":28,"dose":74,"refs":76,"notes":79,"allowedFormulations":86},"htn","hypertension",{"fa":67,"en":68},"فشار خون — شروع ۱۰۰ mg دو بار در روز","Hypertension — start 100 mg twice daily",{"minAge":70},{"value":71,"unit":72},18,"year","fixed",{"perDose":27,"dosesPerDay":75},2,[77],{"source":33,"section":78},"Dosage and Administration",[80],{"text":81,"refs":84},{"fa":82,"en":83},"هر ۲ تا ۳ روز ۱۰۰ mg دو بار افزایش؛ نگهدارنده معمول ۲۰۰ تا ۴۰۰ mg دو بار در روز.","Increase by 100 mg twice daily every 2–3 days; usual maintenance 200–400 mg twice daily.",[85],{"source":33,"section":78},[22,36,44],{"id":54,"disease":88,"label":89,"population":92,"type":73,"unit":28,"dose":94,"refs":96,"allowedFormulations":99,"notes":100},"hypertensive-emergency",{"fa":90,"en":91},"فشار خون شدید — ۲۰ mg وریدی آهسته در ۲ دقیقه، سپس ۴۰ تا ۸۰ mg هر ۱۰ دقیقه","Severe hypertension — 20 mg slow IV over 2 min, then 40–80 mg every 10 min",{"minAge":93},{"value":71,"unit":72},{"perDose":95,"dosesPerDay":5},20,[97],{"source":61,"section":98},"Dosage and Administration — Repeated Intravenous Injection",[52],[101],{"text":102,"refs":105},{"fa":103,"en":104},"بیمار خوابیده؛ فشار پیش از تزریق و ۵ و ۱۰ دقیقه بعد. تزریق‌های بعدی ۴۰ یا ۸۰ mg هر ۱۰ دقیقه تا فشار مطلوب یا مجموع ۳۰۰ mg. جایگزین: انفوزیون آهسته ۱ mg\u002FmL.","Supine; BP before and 5 and 10 min after. Further 40 or 80 mg every 10 min until target BP or a total of 300 mg. Alternative: slow infusion of 1 mg\u002FmL.",[106,107],{"source":61,"section":98},{"source":61,"section":108},"Dosage and Administration — Slow Continuous Infusion",[110,119],{"id":111,"severity":112,"text":113,"refs":116},"ci","block",{"fa":114,"en":115},"آسم؛ نارسایی آشکار قلب؛ بلوک بیش از درجه ۱؛ شوک کاردیوژنیک؛ برادی‌کاردی شدید؛ افت فشار طولانی.","Bronchial asthma; overt heart failure; greater than first-degree block; cardiogenic shock; severe bradycardia; prolonged hypotension.",[117],{"source":33,"section":118},"Contraindications",{"id":120,"severity":112,"text":121,"refs":124},"inj-ci",{"fa":122,"en":123},"تزریقی: آسم، نارسایی آشکار قلب، بلوک بالاتر از درجه ۱، شوک کاردیوژنیک، برادی‌کاردی شدید، افت فشار شدید طولانی.","Injection: asthma, overt heart failure, heart block above first degree, cardiogenic shock, severe bradycardia, severe prolonged hypotension.",[125],{"source":61,"section":118},[],[],[],[],{"status":131,"reviewer":132,"date":132},"unverified",null,[134,139],{"regimen":64,"formulation":22,"input":135,"expect":138},{"ageYears":136,"weightKg":137},50,80,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":54,"formulation":52,"input":140,"expect":141},{"ageYears":136,"weightKg":137},{"perDose":95,"mlPerDose":142},4,[144],"C07AG01",{"status":146,"forms":147,"refs":172},"registered",[148,152,156,160,164,168],{"code":149,"en":150,"fa":151},"09314","LABETALOL 100MG TAB","قرص لابتالول ۱۰۰ میلی‌گرم",{"code":153,"en":154,"fa":155},"09315","LABETALOL 200MG TAB","قرص لابتالول ۲۰۰ میلی‌گرم",{"code":157,"en":158,"fa":159},"09316","LABETALOL 400MG TAB","قرص لابتالول ۴۰۰ میلی‌گرم",{"code":161,"en":162,"fa":163},"08004","LABETALOL 5MG\u002FML 20ML INJ","فرآورده تزریقی لابتالول ۵ میلی‌گرم \u002F میلی‌لیتر ۲۰ میلی‌لیتر",{"code":165,"en":166,"fa":167},"52006","LABETALOL HYDROCHLORIDE INJECTION PARENTERAL 5 mg\u002F1mL 4 mL","فرآورده تزریقی لابتالول هیدروکلراید ۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۴ میلی‌لیتر",{"code":169,"en":170,"fa":171},"52258","LABETALOL HYDROCHLORIDE INJECTION PARENTERAL 5 mg\u002F1mL 10 mL","فرآورده تزریقی لابتالول هیدروکلراید ۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۱۰ میلی‌لیتر",[173],{"source":174,"section":175,"url":176},"darooyab-generic","G-1725\u002FLabetalol","https:\u002F\u002Fwww.darooyab.ir\u002FG-1725\u002FLabetalol",[178,182,186,189,192,195],{"kind":179,"url":180,"label":181},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207743","ANDA207743",{"kind":183,"url":184,"label":185},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=63ede355-42ec-4c52-a941-51e5f6b35ed6","FDA Labetalol",{"kind":183,"url":187,"label":188},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=abfc6b75-1ed5-41f1-0484-4597488237bc","FDA Labetalol inj.",{"kind":190,"url":191,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa685034.html",{"kind":193,"url":194,"label":144},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C07AG01",{"kind":196,"url":176,"label":8},"darooyab",{"pregnancy":198,"lactation":207,"pediatric":215},{"level":199,"text":200,"quote":203,"refs":204},"caution",{"fa":201,"en":202},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category C Teratogenic studies were performed with labetalol in rats and rabbits at oral doses up to approximately six and four times the maximum recommended human dose (MRHD), respectively.",[205],{"source":33,"section":206},"Pregnancy",{"level":199,"text":208,"quote":211,"refs":212},{"fa":209,"en":210},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when labetalol hydrochloride is administered to a nursing woman..",[213],{"source":33,"section":214},"Nursing Mothers",{"level":216,"text":217,"quote":220,"refs":221},"not-established",{"fa":218,"en":219},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[222],{"source":33,"section":223},"Pediatric Use",{"kind":225,"refs":226,"id":181},"ANDA",[227],{"source":33,"section":228},"SPL approval \u002F marketing category",1792191868667]