[{"data":1,"prerenderedAt":359},["ShallowReactive",2],{"drug-levofloxacin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":202,"warnings":221,"renal":222,"monitoring":223,"interactions":224,"review":225,"examples":228,"atc":258,"iran":260,"links":300,"populations":320,"usApproval":354},"levofloxacin",1,{"fa":7,"en":8},"لووفلوکساسین","Levofloxacin","anti-infectives",{"fa":11,"en":12},"فلوروکینولون","Fluoroquinolone",[14],{"name":15,"market":16},"Levaquin","US",[18,19,7,20],"levaquin","لواکین","لووفلوکسازین",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-250","tablet","oral","250 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},250,"mg",false,[16],[33],{"source":34,"section":35},"fda-levofloxacin","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-500","500 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},500,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-750","750 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},750,[16],[51],{"source":34,"section":35},[53,71,83,95,108,119,132,149,174],{"id":54,"disease":55,"label":56,"population":59,"type":63,"unit":29,"dose":64,"refs":65,"durationDays":68},"cap","community-acquired-pneumonia",{"fa":57,"en":58},"پنومونی اکتسابی از جامعه: ۵۰۰ mg روزانه ۷ تا ۱۴ روز (یا ۷۵۰ mg، ۵ روز)","Community-acquired pneumonia: 500 mg daily 7–14 days (or 750 mg for 5 days)",{"minAge":60},{"value":61,"unit":62},18,"year","fixed",{"perDose":40,"perDoseMax":48,"dosesPerDay":5},[66],{"source":34,"section":67},"2.1, Table 1",{"min":69,"max":70},5,14,{"id":72,"disease":73,"label":74,"population":77,"type":63,"unit":29,"dose":79,"refs":80,"durationDays":82},"sinusitis","acute-bacterial-sinusitis",{"fa":75,"en":76},"سینوزیت باکتریایی حاد: ۵۰۰ mg روزانه ۱۰ تا ۱۴ روز (یا ۷۵۰ mg، ۵ روز)","Acute bacterial sinusitis: 500 mg daily 10–14 days (or 750 mg for 5 days)",{"minAge":78},{"value":61,"unit":62},{"perDose":40,"perDoseMax":48,"dosesPerDay":5},[81],{"source":34,"section":67},{"min":69,"max":70},{"id":84,"disease":84,"label":85,"population":88,"type":63,"unit":29,"dose":90,"refs":91,"durationDays":93},"aecb",{"fa":86,"en":87},"تشدید باکتریایی برونشیت مزمن: ۵۰۰ mg روزانه ۷ روز","Acute bacterial exacerbation of chronic bronchitis: 500 mg daily, 7 days",{"minAge":89},{"value":61,"unit":62},{"perDose":40,"dosesPerDay":5},[92],{"source":34,"section":67},{"min":94,"max":94},7,{"id":96,"disease":97,"label":98,"population":101,"type":63,"unit":29,"dose":103,"refs":104,"durationDays":106},"uti","urinary-tract-infection",{"fa":99,"en":100},"UTI بدون عارضه: ۲۵۰ mg روزانه ۳ روز","Uncomplicated UTI: 250 mg daily, 3 days",{"minAge":102},{"value":61,"unit":62},{"perDose":28,"dosesPerDay":5},[105],{"source":34,"section":67},{"min":107,"max":107},3,{"id":109,"disease":97,"label":110,"population":113,"type":63,"unit":29,"dose":115,"refs":116,"durationDays":118},"cuti",{"fa":111,"en":112},"UTI عارضه‌دار\u002Fپیلونفریت: ۷۵۰ mg روزانه ۵ روز","Complicated UTI\u002Fpyelonephritis: 750 mg daily, 5 days",{"minAge":114},{"value":61,"unit":62},{"perDose":48,"dosesPerDay":5},[117],{"source":34,"section":67},{"min":69,"max":69},{"id":120,"disease":121,"label":122,"population":125,"type":63,"unit":29,"dose":127,"refs":128,"durationDays":130},"sssi","skin-soft-tissue-infection",{"fa":123,"en":124},"عفونت پوست بدون عارضه: ۵۰۰ mg روزانه ۷ تا ۱۰ روز","Uncomplicated skin infection: 500 mg daily, 7–10 days",{"minAge":126},{"value":61,"unit":62},{"perDose":40,"dosesPerDay":5},[129],{"source":34,"section":67},{"min":94,"max":131},10,{"id":133,"disease":55,"label":134,"population":137,"type":139,"unit":29,"dose":140,"refs":144},"peds",{"fa":135,"en":136},"کودکان","Children",{"maxAge":138},{"value":61,"unit":62},"notCalculated",{"reason":141},{"fa":142,"en":143},"در کودکان فقط برای سیاه‌زخم استنشاقی و طاعون (۶ ماه به بالا) تأیید شده؛ قرص فقط برای ۳۰ kg به بالا.","In children approved only for inhalational anthrax and plague (≥6 months); tablets only for ≥30 kg.",[145,147],{"source":34,"section":146},"8.4",{"source":34,"section":148},"2",{"id":150,"disease":150,"label":151,"population":154,"type":63,"unit":29,"dose":159,"refs":160,"durationDays":165,"notes":166},"plague",{"fa":152,"en":153},"طاعون — بزرگسال و کودک ≥۵۰ kg: ۵۰۰ mg هر ۲۴ ساعت، ۱۰ تا ۱۴ روز","Plague — adults and children ≥50 kg: 500 mg every 24 h, 10–14 days",{"minAge":155,"minWeightKg":158},{"value":156,"unit":157},6,"month",50,{"perDose":40,"dosesPerDay":5},[161,163],{"source":34,"section":162},"2.1",{"source":34,"section":164},"2.2, Table 2",{"min":131,"max":70},[167],{"text":168,"refs":171},{"fa":169,"en":170},"تأیید طاعون بر اساس مطالعات حیوانی است (مطالعه انسانی ممکن نبود). شروع هرچه زودتر پس از تماس یا تشخیص.","Plague approval is based on animal studies (human trials not feasible). Start as soon as possible after exposure or diagnosis.",[172],{"source":34,"section":173},"1.8",{"id":175,"disease":150,"label":176,"population":179,"type":63,"unit":29,"dose":184,"refs":186,"durationDays":188,"allowedFormulations":189,"notes":190},"plague-child",{"fa":177,"en":178},"طاعون — کودک ۳۰ تا \u003C۵۰ kg: ۲۵۰ mg هر ۱۲ ساعت، ۱۰ تا ۱۴ روز","Plague — child 30 to \u003C50 kg: 250 mg every 12 h, 10–14 days",{"minAge":180,"maxAge":181,"minWeightKg":182,"maxWeightKg":183},{"value":156,"unit":157},{"value":61,"unit":62},30,49.99,{"perDose":28,"dosesPerDay":185},2,[187],{"source":34,"section":164},{"min":131,"max":70},[23],[191,195],{"text":192,"refs":193},{"fa":169,"en":170},[194],{"source":34,"section":173},{"text":196,"refs":199},{"fa":197,"en":198},"زیر ۳۰ kg قرص مناسب نیست؛ فرآورده دیگر لازم است.","Tablets cannot be used under 30 kg; another formulation is needed.",[200],{"source":34,"section":201},"2.2",[203,212],{"id":204,"severity":205,"text":206,"refs":209},"ci","block",{"fa":207,"en":208},"حساسیت به لووفلوکساسین یا سایر کینولون‌ها.","Hypersensitivity to levofloxacin or other quinolones.",[210],{"source":34,"section":211},"4",{"id":213,"severity":214,"text":215,"refs":218},"boxed","warn",{"fa":216,"en":217},"هشدار جعبه‌ای: تاندونیت و پارگی تاندون، نوروپاتی محیطی، اثرات CNS و تشدید میاستنی گراویس؛ در میاستنی پرهیز شود.","Boxed warning: tendinitis and tendon rupture, peripheral neuropathy, CNS effects and exacerbation of myasthenia gravis; avoid in myasthenia gravis.",[219],{"source":34,"section":220},"Boxed Warning",[],[],[],[],{"status":226,"reviewer":227,"date":227},"unverified",null,[229,233,237,241,244,247,250,253],{"regimen":54,"formulation":37,"input":230,"expect":232},{"ageYears":158,"weightKg":231},70,{"perDose":40},{"regimen":72,"formulation":37,"input":234,"expect":236},{"ageYears":235,"weightKg":231},40,{"perDose":40},{"regimen":84,"formulation":37,"input":238,"expect":240},{"ageYears":239,"weightKg":231},60,{"perDose":40},{"regimen":96,"formulation":23,"input":242,"expect":243},{"ageYears":182,"weightKg":239},{"perDose":28},{"regimen":109,"formulation":45,"input":245,"expect":246},{"ageYears":235,"weightKg":231},{"perDose":48},{"regimen":120,"formulation":37,"input":248,"expect":249},{"ageYears":235,"weightKg":231},{"perDose":40},{"regimen":150,"formulation":37,"input":251,"expect":252},{"ageYears":235,"weightKg":231},{"perDose":40,"tabletsPerDoseRounded":5},{"regimen":175,"formulation":23,"input":254,"expect":257},{"ageYears":255,"weightKg":256},11,38,{"perDose":28,"tabletsPerDoseRounded":5},[259],"J01MA12",{"status":261,"forms":262,"refs":295},"registered",[263,267,271,275,279,283,287,291],{"code":264,"en":265,"fa":266},"06756","LEVOFLOXACIN 250MG TAB","قرص لووفلوکساسین ۲۵۰ میلی‌گرم",{"code":268,"en":269,"fa":270},"07183","LEVOFLOXACIN 500MG TAB","قرص لووفلوکساسین ۵۰۰ میلی‌گرم",{"code":272,"en":273,"fa":274},"16320","LEVOFLOXACIN 500MG\u002F100ML VIAL","ویال لووفلوکساسین ۵۰۰ میلی‌گرم \u002F ۱۰۰ میلی‌لیتر",{"code":276,"en":277,"fa":278},"21853","LEVOFLOXACIN 500MG\u002F20ML INJ","فرآورده تزریقی لووفلوکساسین ۵۰۰ میلی‌گرم \u002F ۲۰ میلی‌لیتر",{"code":280,"en":281,"fa":282},"18626","LEVOFLOXACIN 5MG\u002FML 0.5ML OPH DROP","قطره چشمی لووفلوکساسین ۵ میلی‌گرم \u002F میلی‌لیتر ۰٫۵ میلی‌لیتر",{"code":284,"en":285,"fa":286},"12280","LEVOFLOXACIN 5MG\u002FML 5ML OPH DROP","قطره چشمی لووفلوکساسین ۵ میلی‌گرم \u002F میلی‌لیتر ۵ میلی‌لیتر",{"code":288,"en":289,"fa":290},"19797","LEVOFLOXACIN 750MG TAB","قرص لووفلوکساسین ۷۵۰ میلی‌گرم",{"code":292,"en":293,"fa":294},"50371","LEVOFLOXACIN HEMIHYDRATE SOLUTION, DROPS OPHTHALMIC 0.5 % 0.3 mL","قطره چشمی لووفلوکساسین همی‌هیدرات ۰٫۵ درصد ۰٫۳ میلی‌لیتر",[296],{"source":297,"section":298,"url":299},"darooyab-generic","G-421\u002FLevofloxacin","https:\u002F\u002Fwww.darooyab.ir\u002FG-421\u002FLevofloxacin",[301,305,309,312,315,318],{"kind":302,"url":303,"label":304},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=076710","ANDA076710",{"kind":306,"url":307,"label":308},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=ac4001ca-882f-4d9b-a570-c1b9d7fd6830","FDA Levofloxacin",{"kind":310,"url":311,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa697040.html",{"kind":310,"url":313,"label":314},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601154.html","Levofloxacin Injection",{"kind":316,"url":317,"label":259},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01MA12",{"kind":319,"url":299,"label":8},"darooyab",{"pregnancy":321,"lactation":330,"pediatric":339,"geriatric":346},{"level":322,"text":323,"quote":326,"refs":327},"caution",{"fa":324,"en":325},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Published information from case reports, case control studies and observational studies on levofloxacin administered during pregnancy have not identified any drug-associated risk of major birth defects, miscarriage or adverse maternal or fetal outcomes.",[328],{"source":34,"section":329},"8.1",{"level":331,"text":332,"quote":335,"refs":336},"avoid",{"fa":333,"en":334},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Alternatively, advise a lactating woman that breastfeeding is not recommended during treatment with levofloxacin and for an additional two days (five half-lives) after the last dose [see Use in Specific Populations ( 8.4 ) and Clinical Pharmacology ( 12.3 )].",[337],{"source":34,"section":338},"8.2",{"level":322,"text":340,"quote":343,"refs":344},{"fa":341,"en":342},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Inhalational Anthrax (Post-Exposure) Levofloxacin is indicated in pediatric patients 6 months of age and older, for inhalational anthrax (post-exposure).",[345],{"source":34,"section":146},{"level":322,"text":347,"quote":350,"refs":351},{"fa":348,"en":349},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Caution should be used when prescribing levofloxacin to elderly patients especially those on corticosteroids.",[352],{"source":34,"section":353},"8.5",{"kind":355,"refs":356,"id":304},"ANDA",[357],{"source":34,"section":358},"SPL approval \u002F marketing category",1792191872401]