[{"data":1,"prerenderedAt":205},["ShallowReactive",2],{"drug-levonorgestrel-ius":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":36,"contraindications":74,"warnings":84,"renal":92,"monitoring":93,"interactions":94,"review":95,"examples":98,"atc":109,"iran":111,"links":139,"populations":158,"usApproval":200},"levonorgestrel-ius",1,{"fa":7,"en":8},"سیستم داخل رحمی لوونورژسترل (میرنا)","Levonorgestrel intrauterine system 52 mg","genitourinary-sex-hormones",{"fa":11,"en":12},"پروژستین داخل رحمی","Intrauterine progestin",[14],{"name":15,"market":16},"Mirena","US",[18,19,20,21,22],"mirena","میرنا","آی یو دی هورمونی","LNG-IUS","IUD",[24],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":31,"refs":32},"ius","intrauterine-system","intrauterine","One T-shaped system with 52 mg levonorgestrel (about 21 mcg\u002Fday at first)",{"amount":5,"unit":30,"perUnit":30},"application",[16],[33],{"source":34,"section":35},"fda-mirena","3",[37,62],{"id":38,"disease":39,"label":40,"population":43,"type":44,"unit":30,"dose":45,"refs":46,"durationDays":51,"notes":52},"contra","contraception",{"fa":41,"en":42},"پیشگیری از بارداری تا ۸ سال — یک سیستم داخل رحمی","Prevention of pregnancy for up to 8 years — one intrauterine system",{},"fixed",{"perDose":5,"dosesPerDay":5},[47,49],{"source":34,"section":48},"1",{"source":34,"section":50},"2.1",{"min":5,"max":5},[53],{"text":54,"refs":57},{"fa":55,"en":56},"گذاشتن توسط فرد آموزش‌دیده با روش استریل؛ معاینه مجدد ۴ تا ۶ هفته بعد و سپس سالانه.","Inserted by a trained provider with strict asepsis; re-examine at 4–6 weeks and then yearly.",[58,60],{"source":34,"section":59},"2.2",{"source":34,"section":61},"2.3",{"id":63,"disease":64,"label":65,"population":68,"type":44,"unit":30,"dose":69,"refs":70,"durationDays":73},"hmb","heavy-menstrual-bleeding",{"fa":66,"en":67},"خونریزی شدید قاعدگی در زنانی که IUD را برای پیشگیری انتخاب کرده‌اند — تا ۵ سال","Heavy menstrual bleeding in women choosing intrauterine contraception — up to 5 years",{},{"perDose":5,"dosesPerDay":5},[71,72],{"source":34,"section":48},{"source":34,"section":50},{"min":5,"max":5},[75],{"id":76,"severity":77,"text":78,"refs":81},"ci","block",{"fa":79,"en":80},"بارداری یا شک به آن؛ پیشگیری اورژانسی؛ ناهنجاری رحم که حفره را تغییر دهد؛ PID حاد یا سابقه آن؛ اندومتریت پس از زایمان یا سقط عفونی در ۳ ماه اخیر؛ سرطان پستان یا سرطان حساس به پروژستین؛ سرطان رحم یا دهانه رحم؛ بیماری حاد کبد یا تومور کبد.","Pregnancy or suspicion; emergency contraception; uterine anomaly distorting the cavity; acute or prior PID; postpartum endometritis or infected abortion in the past 3 months; breast or progestin-sensitive cancer; uterine or cervical malignancy; acute liver disease or liver tumour.",[82],{"source":34,"section":83},"4",[85],{"text":86,"refs":89},{"fa":87,"en":88},"حاملگی خارج رحمی؛ خطرات بارداری داخل رحمی با IUD؛ سپسیس؛ عفونت لگن؛ سوراخ شدن رحم؛ خروج خودبه‌خود؛ کیست تخمدان؛ تغییر الگوی خونریزی.","Ectopic pregnancy; risks of intrauterine pregnancy with the device; sepsis; pelvic infection; perforation; expulsion; ovarian cysts; bleeding pattern changes.",[90],{"source":34,"section":91},"5",[],[],[],{"status":96,"reviewer":97,"date":97},"unverified",null,[99,104],{"regimen":38,"formulation":25,"input":100,"expect":103},{"ageYears":101,"weightKg":102},30,60,{"perDose":5},{"regimen":63,"formulation":25,"input":105,"expect":108},{"ageYears":106,"weightKg":107},40,70,{"perDose":5},[110],"G02BA03",{"status":112,"forms":113,"refs":134},"registered",[114,118,122,126,130],{"code":115,"en":116,"fa":117},"00750","LEVONORGESTREL 0.03MG TAB","قرص لوونورژسترل ۰٫۰۳ میلی‌گرم",{"code":119,"en":120,"fa":121},"02441","LEVONORGESTREL 0.75MG TAB","قرص لوونورژسترل ۰٫۷۵ میلی‌گرم",{"code":123,"en":124,"fa":125},"16870","LEVONORGESTREL 1.5MG TAB","قرص لوونورژسترل ۱٫۵ میلی‌گرم",{"code":127,"en":128,"fa":129},"08959","LEVONORGESTREL 52MG IUD","آی‌یودی لوونورژسترل ۵۲ میلی‌گرم",{"code":131,"en":132,"fa":133},"01572","LEVONORGESTREL 6X36MG IMPLANT","ایمپلنت لوونورژسترل ۶ X ۳۶ میلی‌گرم",[135],{"source":136,"section":137,"url":138},"darooyab-generic","G-3293\u002FLevonorgestrel","https:\u002F\u002Fwww.darooyab.ir\u002FG-3293\u002FLevonorgestrel",[140,144,148,152,155],{"kind":141,"url":142,"label":143},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021225","NDA021225",{"kind":145,"url":146,"label":147},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=dcbd6aa2-b3fa-479a-a676-56ea742962fc","FDA Mirena",{"kind":149,"url":150,"label":151},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa613047.html","Levonorgestrel Intrauterine System",{"kind":153,"url":154,"label":110},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G02BA03",{"kind":156,"url":138,"label":157},"darooyab","Levonorgestrel",{"pregnancy":159,"lactation":167,"pediatric":176,"geriatric":184,"reproductive":192},{"level":160,"text":161,"quote":164,"refs":165},"contraindicated",{"fa":162,"en":163},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","The use of Mirena is contraindicated when one or more of the following conditions exist: • Pregnancy or suspicion of pregnancy [see Warnings and Precautions ( 5.2 ), Use in Specific Populations ( 8.1 )] • For use as post-coital contraception (emergency contraception) • Congenital or acquired uterine anomaly including …",[166],{"source":34,"section":83},{"level":168,"text":169,"quote":172,"refs":173},"caution",{"fa":170,"en":171},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Published studies report the presence of LNG in human milk.",[174],{"source":34,"section":175},"8.2",{"level":168,"text":177,"quote":180,"refs":181},{"fa":178,"en":179},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and efficacy of Mirena have been established in women of reproductive age.",[182],{"source":34,"section":183},"8.4",{"level":168,"text":185,"quote":188,"refs":189},{"fa":186,"en":187},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Mirena has not been studied in women over age 65 and is not approved for use in this population.",[190],{"source":34,"section":191},"8.5",{"level":168,"text":193,"quote":196,"refs":197},{"fa":194,"en":195},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Return to Fertility After Discontinuing Mirena In two studies, return to fertility was investigated in a total of 229 women who desired pregnancy after study discontinuation and provided follow-up information.",[198],{"source":34,"section":199},"8.3",{"kind":201,"refs":202,"id":143},"NDA",[203],{"source":34,"section":204},"SPL approval \u002F marketing category",1792444704943]