[{"data":1,"prerenderedAt":251},["ShallowReactive",2],{"drug-lithium":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":52,"contraindications":108,"warnings":128,"renal":136,"monitoring":137,"interactions":147,"review":148,"examples":151,"atc":167,"iran":169,"links":193,"populations":212,"usApproval":246},"lithium",1,{"fa":7,"en":8},"لیتیوم","Lithium carbonate","nervous-system",{"fa":11,"en":12},"تثبیت‌کننده خلق","Mood stabilizer",[14],{"name":15,"market":16},"Lithobid","US",[18,4,19],"لیتیم","کربنات لیتیوم",[21,35,45],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-300","tablet","oral","300 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},300,"mg",true,[16],[32],{"source":33,"section":34},"fda-lithium","3",{"id":36,"form":37,"route":24,"label":38,"concentration":39,"markets":42,"refs":43},"cap-150","capsule","150 mg capsule",{"amount":40,"unit":28,"perUnit":37,"scored":41},150,false,[16],[44],{"source":33,"section":34},{"id":46,"form":37,"route":24,"label":47,"concentration":48,"markets":49,"refs":50},"cap-300","300 mg capsule",{"amount":27,"unit":28,"perUnit":37,"scored":41},[16],[51],{"source":33,"section":34},[53,83],{"id":54,"disease":55,"label":56,"population":59,"type":64,"unit":28,"dose":65,"refs":71,"notes":74},"over30","bipolar-mania",{"fa":57,"en":58},"دوقطبی نوع ۱ — بزرگسال و کودک بالای ۳۰ kg: شروع ۳۰۰ mg سه بار در روز","Bipolar I — adults and children >30 kg: start 300 mg three times daily",{"minAge":60,"minWeightKg":63},{"value":61,"unit":62},7,"year",30.01,"titration",{"dividedDoses":66,"titration":67},3,{"start":68,"increment":27,"incrementEveryDays":66,"targetMin":69,"targetMax":70,"max":70},900,1200,1800,[72],{"source":33,"section":73},"2.2, Table 1",[75],{"text":76,"refs":79},{"fa":77,"en":78},"هدف حاد: ۶۰۰ mg دو تا سه بار در روز (سطح ۰٫۸ تا ۱٫۲ mEq\u002FL)؛ نگهدارنده ۳۰۰ تا ۶۰۰ mg دو تا سه بار در روز (۰٫۸ تا ۱٫۰). سطح سرمی ۳ روز بعد، ۱۲ ساعت پس از دوز.","Acute goal: 600 mg 2–3 times daily (0.8–1.2 mEq\u002FL); maintenance 300–600 mg 2–3 times daily (0.8–1.0). Check serum level after 3 days, 12 h post-dose.",[80,81],{"source":33,"section":73},{"source":33,"section":82},"2.2",{"id":84,"disease":55,"label":85,"population":88,"type":64,"unit":28,"dose":94,"refs":99,"notes":101},"20-30kg",{"fa":86,"en":87},"دوقطبی نوع ۱ — کودک ۲۰ تا ۳۰ kg: شروع ۳۰۰ mg دو بار در روز","Bipolar I — children 20–30 kg: start 300 mg twice daily",{"minAge":89,"maxAge":90,"minWeightKg":92,"maxWeightKg":93},{"value":61,"unit":62},{"value":91,"unit":62},18,20,30,{"dividedDoses":95,"titration":96},2,{"start":97,"increment":27,"incrementEveryDays":61,"targetMin":97,"targetMax":98,"max":98},600,1500,[100],{"source":33,"section":73},[102],{"text":103,"refs":106},{"fa":104,"en":105},"حاد: ۶۰۰ تا ۱۵۰۰ mg\u002Fday منقسم؛ نگهدارنده ۶۰۰ تا ۱۲۰۰ mg\u002Fday.","Acute: 600–1500 mg\u002Fday divided; maintenance 600–1200 mg\u002Fday.",[107],{"source":33,"section":73},[109,120],{"id":110,"severity":111,"rule":112,"text":114,"refs":117},"under-7","block",{"maxAge":113},{"value":61,"unit":62},{"fa":115,"en":116},"بی‌خطری زیر ۷ سال ثابت نشده است.","Not established under 7 years.",[118],{"source":33,"section":119},"8.4",{"id":121,"severity":111,"text":122,"refs":125},"hypersensitivity",{"fa":123,"en":124},"حساسیت به اجزای فرآورده.","Hypersensitivity to any inactive ingredient.",[126],{"source":33,"section":127},"4",[129],{"text":130,"refs":133},{"fa":131,"en":132},"هشدار جعبه‌ای: مسمومیت لیتیوم نزدیک به سطوح درمانی رخ می‌دهد؛ امکان اندازه‌گیری سطح سرمی پیش از شروع لازم است.","Boxed warning: lithium toxicity can occur close to therapeutic levels; serum level testing must be available before starting.",[134],{"source":33,"section":135},"WARNING: LITHIUM TOXICITY",[],[138],{"text":139,"refs":142},{"fa":140,"en":141},"پیش از شروع: کلیه، علائم حیاتی، الکترولیت، تیروئید، بارداری. سطح سرمی پس از هر تغییر دوز یا داروهای همراه (دیورتیک، NSAID، ARB\u002FACEI، مترونیدازول).","Before start: renal function, vitals, electrolytes, thyroid, pregnancy. Check serum level after any dose change or new interacting drug (diuretics, NSAIDs, RAS antagonists, metronidazole).",[143,145],{"source":33,"section":144},"2.1",{"source":33,"section":146},"2.3",[],{"status":149,"reviewer":150,"date":150},"unverified",null,[152,156,161],{"regimen":54,"formulation":22,"input":153,"expect":155},{"ageYears":93,"weightKg":154},70,{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":84,"formulation":22,"input":157,"expect":160},{"ageYears":158,"weightKg":159},9,25,{"perDose":27},{"regimen":54,"formulation":22,"input":162,"expect":165},{"ageYears":163,"weightKg":164},6,35,{"status":166},"blocked",[168],"N05AN01",{"status":170,"forms":171,"refs":188},"registered",[172,176,180,184],{"code":173,"en":174,"fa":175},"09674","LITHIUM 295MG TAB","قرص لیتیوم ۲۹۵ میلی‌گرم",{"code":177,"en":178,"fa":179},"12578","LITHIUM CARBONATE 200MG  TAB","قرص لیتیوم کربنات ۲۰۰ میلی‌گرم",{"code":181,"en":182,"fa":183},"00767","LITHIUM CARBONATE 300MG TAB","قرص لیتیوم کربنات ۳۰۰ میلی‌گرم",{"code":185,"en":186,"fa":187},"00768","LITHIUM CARBONATE SR 400MG TAB","قرص آهسته‌رهش لیتیوم کربنات ۴۰۰ میلی‌گرم",[189],{"source":190,"section":191,"url":192},"darooyab-generic","G-591\u002FLithium-Carbonate","https:\u002F\u002Fwww.darooyab.ir\u002FG-591\u002FLithium-Carbonate",[194,198,202,206,209],{"kind":195,"url":196,"label":197},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=018558","NDA018558",{"kind":199,"url":200,"label":201},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b839ff4b-f62d-41ab-a823-550a756d58ec","FDA Lithium",{"kind":203,"url":204,"label":205},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa681039.html","Lithium",{"kind":207,"url":208,"label":168},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AN01",{"kind":210,"url":192,"label":211},"darooyab","Lithium-Carbonate",{"pregnancy":213,"lactation":222,"pediatric":230,"geriatric":238},{"level":214,"text":215,"quote":218,"refs":219},"avoid",{"fa":216,"en":217},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary: Lithium may cause harm when administered to a pregnant woman.",[220],{"source":33,"section":221},"8.1",{"level":214,"text":223,"quote":226,"refs":227},{"fa":224,"en":225},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Breastfeeding is not recommended with maternal lithium use; however, if a woman chooses to breastfeed, the infant should be closely monitored for signs of lithium toxicity.",[228],{"source":33,"section":229},"8.2",{"level":231,"text":232,"quote":235,"refs":236},"caution",{"fa":233,"en":234},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of lithium for monotherapy treatment of acute manic or mixed episodes of bipolar I disorder and maintenance monotherapy of bipolar I disorder in pediatric patients ages 7 to 17 years of age have been established in an acute-phase clinical trial of 8 weeks in duration followed by a 28-week …",[237],{"source":33,"section":119},{"level":231,"text":239,"quote":242,"refs":243},{"fa":240,"en":241},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other treatment.",[244],{"source":33,"section":245},"8.5",{"kind":247,"refs":248,"id":197},"NDA",[249],{"source":33,"section":250},"SPL approval \u002F marketing category",1792191877203]