[{"data":1,"prerenderedAt":211},["ShallowReactive",2],{"drug-medroxyprogesterone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":37,"contraindications":74,"warnings":93,"renal":94,"monitoring":95,"interactions":96,"review":97,"examples":100,"atc":111,"iran":113,"links":149,"populations":171,"usApproval":206},"medroxyprogesterone",1,{"fa":7,"en":8},"مدروکسی‌پروژسترون","Medroxyprogesterone acetate","genitourinary-sex-hormones",{"fa":11,"en":12},"پروژستین","Progestin",[14],{"name":15,"market":16},"Provera","US",[18,19,20,21],"provera","پروورا","مدروکسی پروژسترون","MPA",[23],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"tab-10","tablet","oral","10 mg tablet (scored)",{"amount":29,"unit":30,"perUnit":25,"scored":31},10,"mg",true,[16],[34],{"source":35,"section":36},"fda-medroxyprogesterone","How Supplied",[38,62],{"id":39,"disease":40,"label":41,"population":44,"type":48,"unit":30,"dose":49,"refs":50,"durationDays":53,"notes":55},"amenorrhea","secondary-amenorrhea",{"fa":42,"en":43},"آمنوره ثانویه: ۵ یا ۱۰ mg روزانه، ۵ تا ۱۰ روز","Secondary amenorrhoea: 5 or 10 mg daily for 5–10 days",{"minAge":45},{"value":46,"unit":47},12,"year","fixed",{"perDose":29,"dosesPerDay":5},[51],{"source":35,"section":52},"Dosage and Administration",{"min":54,"max":29},5,[56],{"text":57,"refs":60},{"fa":58,"en":59},"برای تبدیل ترشحی بهینه آندومتر: ۱۰ mg روزانه ۱۰ روز. خونریزی قطع معمولاً ۳ تا ۷ روز پس از توقف.","For optimal secretory transformation: 10 mg daily for 10 days. Withdrawal bleeding usually 3–7 days after stopping.",[61],{"source":35,"section":52},{"id":63,"disease":64,"label":65,"population":68,"type":48,"unit":30,"dose":70,"refs":71,"durationDays":73},"aub","abnormal-uterine-bleeding",{"fa":66,"en":67},"خونریزی غیرطبیعی رحم (هورمونی): ۵ یا ۱۰ mg روزانه ۵ تا ۱۰ روز از روز ۱۶ یا ۲۱ سیکل","Abnormal uterine bleeding (hormonal): 5 or 10 mg daily for 5–10 days from cycle day 16 or 21",{"minAge":69},{"value":46,"unit":47},{"perDose":29,"dosesPerDay":5},[72],{"source":35,"section":52},{"min":54,"max":29},[75,84],{"id":76,"severity":77,"text":78,"refs":81},"ci","block",{"fa":79,"en":80},"خونریزی تناسلی تشخیص‌داده‌نشده؛ سرطان پستان یا نئوپلازی وابسته به هورمون؛ DVT\u002FPE یا ترومبوآمبولی شریانی (فعلی یا سابقه)؛ بیماری کبد؛ بارداری؛ آنافیلاکسی به دارو.","Undiagnosed genital bleeding; breast cancer or hormone-dependent neoplasia; current or past DVT\u002FPE or arterial thromboembolism; liver disease; pregnancy; anaphylaxis to the drug.",[82],{"source":35,"section":83},"Contraindications",{"id":85,"severity":86,"text":87,"refs":90},"boxed","warn",{"fa":88,"en":89},"هشدار جعبه‌ای: با استروژن خطر DVT، PE، سکته، MI، سرطان پستان و دمانس در زنان یائسه.","Boxed warning: with oestrogen, increased risk of DVT, PE, stroke, MI, breast cancer and dementia in postmenopausal women.",[91],{"source":35,"section":92},"Boxed Warning",[],[],[],[],{"status":98,"reviewer":99,"date":99},"unverified",null,[101,106],{"regimen":39,"formulation":24,"input":102,"expect":105},{"ageYears":103,"weightKg":104},25,60,{"perDose":29},{"regimen":63,"formulation":24,"input":107,"expect":110},{"ageYears":108,"weightKg":109},35,65,{"perDose":29},[112],"G03DA02",{"status":114,"forms":115,"refs":144},"registered",[116,120,124,128,132,136,140],{"code":117,"en":118,"fa":119},"00791","MEDROXYPROGESTERONE ACETATE 150MG\u002F1ML AMP","آمپول مدروکسی‌پروژسترون استات ۱۵۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":121,"en":122,"fa":123},"13657","MEDROXYPROGESTERONE ACETATE 150MG\u002F3ML VIAL","ویال مدروکسی‌پروژسترون استات ۱۵۰ میلی‌گرم \u002F ۳ میلی‌لیتر",{"code":125,"en":126,"fa":127},"00789","MEDROXYPROGESTERONE ACETATE 250MG TAB","قرص مدروکسی‌پروژسترون استات ۲۵۰ میلی‌گرم",{"code":129,"en":130,"fa":131},"00793","MEDROXYPROGESTERONE ACETATE 500MG\u002F2.5ML AMP","آمپول مدروکسی‌پروژسترون استات ۵۰۰ میلی‌گرم \u002F ۲٫۵ میلی‌لیتر",{"code":133,"en":134,"fa":135},"00790","MEDROXYPROGESTERONE ACETATE 500MG\u002F5ML VIAL","ویال مدروکسی‌پروژسترون استات ۵۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":137,"en":138,"fa":139},"00792","MEDROXYPROGESTERONE ACETATE 5MG TAB","قرص مدروکسی‌پروژسترون استات ۵ میلی‌گرم",{"code":141,"en":142,"fa":143},"06066","MEDROXYPROGESTRON 500MG\u002F3.3ML VIAL","ویال مدروکسیپروجسترون ۵۰۰ میلی‌گرم \u002F ۳٫۳ میلی‌لیتر",[145],{"source":146,"section":147,"url":148},"darooyab-generic","G-3275\u002FMedroxyprogesterone-Acetate","https:\u002F\u002Fwww.darooyab.ir\u002FG-3275\u002FMedroxyprogesterone-Acetate",[150,154,158,162,165,168],{"kind":151,"url":152,"label":153},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040159","ANDA040159",{"kind":155,"url":156,"label":157},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=cbf142f9-9af3-4d79-9343-0ab42d6dbe9f","FDA Medroxyprogesterone",{"kind":159,"url":160,"label":161},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601041.html","Estrogen and Progestin (Hormone Replacement Therapy)",{"kind":159,"url":163,"label":164},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682470.html","Medroxyprogesterone",{"kind":166,"url":167,"label":112},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=G03DA02",{"kind":169,"url":148,"label":170},"darooyab","Medroxyprogesterone-Acetate",{"pregnancy":172,"lactation":181,"pediatric":190,"geriatric":199},{"level":173,"text":174,"quote":177,"refs":178},"contraindicated",{"fa":175,"en":176},"برچسب: در بارداری منع مصرف دارد.","Label: contraindicated in pregnancy.","Known or suspected pregnancy.",[179],{"source":35,"section":180},"CONTRAINDICATIONS",{"level":182,"text":183,"quote":186,"refs":187},"avoid",{"fa":184,"en":185},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Medroxyprogesterone acetate should not be used during lactation.",[188],{"source":35,"section":189},"Precautions\u002FWarnings – Nursing Mothers",{"level":191,"text":192,"quote":195,"refs":196},"not-established",{"fa":193,"en":194},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Medroxyprogesterone acetate tablets are not indicated in children.",[197],{"source":35,"section":198},"Precautions\u002FWarnings – Pediatric Use",{"level":182,"text":200,"quote":203,"refs":204},{"fa":201,"en":202},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","Cardiovascular Disorders and Probable Dementia Estrogen plus progestin therapy should not be used for the prevention of cardiovascular disease or dementia.",[205],{"source":35,"section":92},{"kind":207,"refs":208,"id":153},"ANDA",[209],{"source":35,"section":210},"SPL approval \u002F marketing category",1792440725491]