[{"data":1,"prerenderedAt":373},["ShallowReactive",2],{"drug-naproxen":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":12,"synonyms":16,"formulations":20,"regimens":62,"contraindications":217,"warnings":236,"renal":237,"monitoring":238,"interactions":239,"review":240,"examples":243,"atc":279,"iran":281,"links":309,"populations":326,"usApproval":368},"naproxen",1,{"fa":7,"en":8},"ناپروکسن","Naproxen","musculoskeletal",{"fa":11,"en":11},"NSAID",[13],{"name":14,"market":15},"Naprosyn","US",[17,18,7,19],"naprosyn","ناپروسین","ناپروکسین",[21,35,43,52],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-250","tablet","oral","250 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},250,"mg",false,[15],[32],{"source":33,"section":34},"fda-naproxen","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-375","375 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},375,[15],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":49,"refs":50},"tab-500","500 mg tablet (scored)",{"amount":47,"unit":28,"perUnit":23,"scored":48},500,true,[15],[51],{"source":33,"section":34},{"id":53,"form":23,"route":24,"label":54,"concentration":55,"markets":57,"refs":58},"otc-220","220 mg naproxen sodium caplet (OTC; = 200 mg naproxen)",{"amount":56,"unit":28,"perUnit":23,"scored":29},220,[15],[59],{"source":60,"section":61},"fda-aleve","Active ingredient",[63,91,105,127,147,173,198],{"id":64,"disease":64,"label":65,"population":68,"type":72,"unit":28,"dose":73,"refs":76,"limits":79,"notes":83,"allowedFormulations":90},"pain",{"fa":66,"en":67},"درد، دیسمنوره، تاندونیت\u002Fبورسیت — بزرگسال: ۲۵۰ mg هر ۶ تا ۸ ساعت (دوز اول ۵۰۰)","Pain, dysmenorrhoea, tendonitis\u002Fbursitis — adults: 250 mg every 6–8 h (first dose 500)",{"minAge":69},{"value":70,"unit":71},18,"year","fixed",{"perDose":27,"dosesPerDay":74,"intervalHours":75},4,6,[77],{"source":33,"section":78},"2.4",{"maxPerDay":80,"refs":81},1250,[82],{"source":33,"section":78},[84],{"text":85,"refs":88},{"fa":86,"en":87},"دوز اول ۵۰۰ mg، سپس ۲۵۰ mg هر ۶ تا ۸ ساعت در صورت نیاز؛ حداکثر ۱۲۵۰ mg\u002Fday.","First dose 500 mg, then 250 mg every 6–8 h as needed; max 1,250 mg\u002Fday.",[89],{"source":33,"section":78},[22,36,44],{"id":92,"disease":92,"label":93,"population":96,"type":72,"unit":28,"dose":98,"refs":99,"limits":101,"allowedFormulations":104},"dysmenorrhea",{"fa":94,"en":95},"دیسمنوره اولیه — ۲۵۰ mg هر ۶ تا ۸ ساعت (دوز اول ۵۰۰)","Primary dysmenorrhoea — 250 mg every 6–8 h (first dose 500)",{"minAge":97},{"value":70,"unit":71},{"perDose":27,"dosesPerDay":74,"intervalHours":75},[100],{"source":33,"section":78},{"maxPerDay":80,"refs":102},[103],{"source":33,"section":78},[22,36,44],{"id":106,"disease":107,"label":108,"population":111,"type":72,"unit":28,"dose":113,"refs":115,"notes":118,"allowedFormulations":126},"arthritis","osteoarthritis",{"fa":109,"en":110},"آرتروز، آرتریت روماتوئید، اسپوندیلیت — ۲۵۰ تا ۵۰۰ mg دو بار در روز","OA, RA, ankylosing spondylitis — 250–500 mg twice daily",{"minAge":112},{"value":70,"unit":71},{"perDose":27,"perDoseMax":47,"dosesPerDay":114},2,[116],{"source":33,"section":117},"2.1, Table 1",[119],{"text":120,"refs":123},{"fa":121,"en":122},"در صورت تحمل تا ۱۵۰۰ mg\u002Fday حداکثر ۶ ماه.","If tolerated up to 1,500 mg\u002Fday for up to 6 months.",[124],{"source":33,"section":125},"2.2",[22,36,44],{"id":128,"disease":128,"label":129,"population":132,"type":72,"unit":28,"dose":134,"refs":136,"notes":139,"allowedFormulations":146},"gout",{"fa":130,"en":131},"حمله حاد نقرس — ۷۵۰ mg، سپس ۲۵۰ mg هر ۸ ساعت","Acute gout — 750 mg, then 250 mg every 8 h",{"minAge":133},{"value":70,"unit":71},{"perDose":27,"dosesPerDay":135},3,[137],{"source":33,"section":138},"2.5",[140],{"text":141,"refs":144},{"fa":142,"en":143},"دوز اول ۷۵۰ mg؛ ادامه تا فروکش حمله.","First dose 750 mg; continue until the attack subsides.",[145],{"source":33,"section":138},[22,36,44],{"id":148,"disease":149,"label":150,"population":153,"type":157,"unit":28,"dose":158,"refs":160,"notes":165,"allowedFormulations":172},"jia","juvenile-arthritis",{"fa":151,"en":152},"آرتریت ایدیوپاتیک نوجوانان — ۵۰ kg به بالا: حدود ۱۰ mg\u002Fkg\u002Fday در ۲ نوبت","Juvenile idiopathic arthritis — ≥50 kg: about 10 mg\u002Fkg\u002Fday in 2 doses",{"minAge":154,"maxAge":155,"minWeightKg":156},{"value":114,"unit":71},{"value":70,"unit":71},50,"weightBased",{"perKgPerDay":159,"dividedDoses":114},10,[161,163],{"source":33,"section":162},"2.3",{"source":33,"section":164},"2",[166],{"text":167,"refs":170},{"fa":168,"en":169},"قرص برای کودکان زیر ۵۰ kg مناسب نیست (سوسپانسیون).","Tablets are not appropriate for children under 50 kg (use suspension).",[171],{"source":33,"section":162},[22,36,44],{"id":174,"disease":175,"label":176,"population":179,"type":72,"unit":28,"dose":182,"refs":183,"limits":186,"allowedFormulations":190,"notes":191},"otc-adult","toothache",{"fa":177,"en":178},"درد (از جمله دندان‌درد) — ۱۲ سال به بالا: ۱ قرص ۲۲۰ mg هر ۸ تا ۱۲ ساعت","Pain incl. toothache — ≥12 y: 1 × 220 mg caplet every 8–12 h",{"minAge":180},{"value":181,"unit":71},12,{"perDose":56,"dosesPerDay":114},[184],{"source":60,"section":185},"Directions",{"maxPerDay":187,"refs":188},660,[189],{"source":60,"section":185},[53],[192],{"text":193,"refs":196},{"fa":194,"en":195},"دوز اول می‌تواند ۲ قرص در ساعت اول باشد؛ حداکثر ۲ قرص در هر ۸ تا ۱۲ ساعت و ۳ قرص در ۲۴ ساعت.","First dose may be 2 caplets within the first hour; max 2 caplets in any 8–12 h and 3 caplets in 24 h.",[197],{"source":60,"section":185},{"id":199,"disease":199,"label":200,"population":203,"type":72,"unit":28,"dose":205,"refs":206,"limits":208,"notes":211,"allowedFormulations":216},"tendonitis",{"fa":201,"en":202},"تاندونیت و بورسیت حاد — بزرگسال","Acute tendonitis and bursitis — adult",{"minAge":204},{"value":70,"unit":71},{"perDose":27,"dosesPerDay":74,"intervalHours":75},[207],{"source":33,"section":78},{"maxPerDay":80,"refs":209},[210],{"source":33,"section":78},[212],{"text":213,"refs":214},{"fa":86,"en":87},[215],{"source":33,"section":78},[22,36,44],[218,227],{"id":219,"severity":220,"text":221,"refs":224},"ci","block",{"fa":222,"en":223},"حساسیت به دارو؛ سابقه آسم، کهیر یا واکنش آلرژیک پس از آسپیرین یا NSAID؛ هنگام جراحی بای‌پس عروق کرونر (CABG).","Hypersensitivity; history of asthma, urticaria or allergic-type reaction after aspirin or other NSAIDs; in the setting of CABG surgery.",[225],{"source":33,"section":226},"4",{"id":228,"severity":229,"text":230,"refs":233},"boxed","warn",{"fa":231,"en":232},"هشدار جعبه‌ای: خطر حوادث قلبی‌عروقی ترومبوتیک و خونریزی، زخم و سوراخ‌شدگی گوارشی.","Boxed warning: risk of serious cardiovascular thrombotic events and GI bleeding, ulceration and perforation.",[234],{"source":33,"section":235},"Boxed Warning",[],[],[],[],{"status":241,"reviewer":242,"date":242},"unverified",null,[244,250,255,260,265,269,273,276],{"regimen":64,"formulation":22,"input":245,"expect":248},{"ageYears":246,"weightKg":247},30,70,{"perDose":27,"perDay":249},1000,{"regimen":92,"formulation":22,"input":251,"expect":254},{"ageYears":252,"weightKg":253},20,55,{"perDose":27},{"regimen":106,"formulation":22,"input":256,"expect":259},{"ageYears":257,"weightKg":258},60,75,{"perDose":27,"upperPerDose":47},{"regimen":128,"formulation":22,"input":261,"expect":263},{"ageYears":156,"weightKg":262},85,{"perDay":264},750,{"regimen":148,"formulation":22,"input":266,"expect":268},{"ageYears":267,"weightKg":156},15,{"perDose":27},{"regimen":148,"formulation":22,"input":270,"expect":271},{"ageYears":159,"weightKg":246},{"status":272},"blocked",{"regimen":174,"formulation":53,"input":274,"expect":275},{"ageYears":246,"weightKg":247},{"perDose":56,"tabletsPerDoseRounded":5},{"regimen":199,"formulation":22,"input":277,"expect":278},{"ageYears":246,"weightKg":247},{"perDose":27,"perDay":249},[280],"M01AE02",{"status":282,"forms":283,"refs":304},"registered",[284,288,292,296,300],{"code":285,"en":286,"fa":287},"18457","NAPROXEN 200MG SOFTGEL CAP","کپسول نرم ناپروکسن ۲۰۰ میلی‌گرم",{"code":289,"en":290,"fa":291},"00889","NAPROXEN 250MG TAB","قرص ناپروکسن ۲۵۰ میلی‌گرم",{"code":293,"en":294,"fa":295},"17398","NAPROXEN 375MG TAB","قرص ناپروکسن ۳۷۵ میلی‌گرم",{"code":297,"en":298,"fa":299},"02076","NAPROXEN 500MG SUPP","شیاف ناپروکسن ۵۰۰ میلی‌گرم",{"code":301,"en":302,"fa":303},"01606","NAPROXEN 500MG TAB","قرص ناپروکسن ۵۰۰ میلی‌گرم",[305],{"source":306,"section":307,"url":308},"darooyab-generic","G-139\u002FNaproxen","https:\u002F\u002Fwww.darooyab.ir\u002FG-139\u002FNaproxen",[310,314,318,321,324],{"kind":311,"url":312,"label":313},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=074140","ANDA074140",{"kind":315,"url":316,"label":317},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=c1cb9bb9-fbae-5e5c-e053-2995a90a0d21","FDA Naproxen",{"kind":319,"url":320,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa681029.html",{"kind":322,"url":323,"label":280},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M01AE02",{"kind":325,"url":308,"label":8},"darooyab",{"pregnancy":327,"lactation":336,"pediatric":345,"geriatric":353,"reproductive":360},{"level":328,"text":329,"quote":332,"refs":333},"avoid",{"fa":330,"en":331},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","… losure of ductus arteriosus), use during pregnancy (particularly starting at 30-weeks of gestation, or third trimester) should be avoided.",[334],{"source":33,"section":335},"8.1",{"level":337,"text":338,"quote":341,"refs":342},"caution",{"fa":339,"en":340},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary The naproxen anion has been found in the milk of lactating women at a concentration equivalent to approximately 1% of maximum naproxen concentration in plasma.",[343],{"source":33,"section":344},"8.2",{"level":337,"text":346,"quote":349,"refs":350},{"fa":347,"en":348},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and effectiveness in pediatric patients below the age of 2 years have not been established.",[351],{"source":33,"section":352},"8.4",{"level":337,"text":354,"quote":357,"refs":358},{"fa":355,"en":356},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Elderly patients and patients with a prior history of peptic ulcer disease and\u002For GI bleeding are at greater risk for serious GI events [ see Warnings and Precautions (5.2) ] .",[359],{"source":33,"section":235},{"level":337,"text":361,"quote":364,"refs":365},{"fa":362,"en":363},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Females Based on the mechanism of action, the use of prostaglandin-mediated NSAIDs, including naproxen tablets may delay or prevent rupture of ovarian follicles, which has been associated with reversible infertility in some women.",[366],{"source":33,"section":367},"8.3",{"kind":369,"refs":370,"id":313},"ANDA",[371],{"source":33,"section":372},"SPL approval \u002F marketing category",1792191875649]