[{"data":1,"prerenderedAt":247},["ShallowReactive",2],{"drug-olanzapine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":76,"contraindications":128,"warnings":129,"renal":130,"monitoring":131,"interactions":132,"review":133,"examples":136,"atc":149,"iran":151,"links":179,"populations":199,"usApproval":242},"olanzapine",1,{"fa":7,"en":8},"الانزاپین","Olanzapine","nervous-system",{"fa":11,"en":12},"آنتی‌سایکوتیک آتیپیک","Atypical antipsychotic",[14],{"name":15,"market":16},"Zyprexa","US",[18,19,20,7],"zyprexa","زیپرکسا","اولانزاپین",[22,36,44,52,60,68],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-2-5","tablet","oral","2.5 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},2.5,"mg",false,[16],[33],{"source":34,"section":35},"fda-zyprexa","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-5","5 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},5,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-7-5","7.5 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},7.5,[16],[51],{"source":34,"section":35},{"id":53,"form":24,"route":25,"label":54,"concentration":55,"markets":57,"refs":58},"tab-10","10 mg tablet",{"amount":56,"unit":29,"perUnit":24,"scored":30},10,[16],[59],{"source":34,"section":35},{"id":61,"form":24,"route":25,"label":62,"concentration":63,"markets":65,"refs":66},"tab-15","15 mg tablet",{"amount":64,"unit":29,"perUnit":24,"scored":30},15,[16],[67],{"source":34,"section":35},{"id":69,"form":24,"route":25,"label":70,"concentration":71,"markets":73,"refs":74},"tab-20","20 mg tablet",{"amount":72,"unit":29,"perUnit":24,"scored":30},20,[16],[75],{"source":34,"section":35},[77,104,115],{"id":78,"disease":79,"label":80,"population":83,"type":89,"unit":29,"dose":90,"refs":93,"notes":96},"schizo-adol","schizophrenia",{"fa":81,"en":82},"اسکیزوفرنی — ۱۳ تا ۱۷ سال: شروع ۲٫۵ یا ۵ mg، هدف ۱۰","Schizophrenia — 13–17 y: start 2.5 or 5 mg, target 10",{"minAge":84,"maxAge":87},{"value":85,"unit":86},13,"year",{"value":88,"unit":86},18,"titration",{"dividedDoses":5,"titration":91},{"start":28,"increment":28,"incrementEveryDays":92,"targetMin":56,"targetMax":56,"max":72},7,[94],{"source":34,"section":95},"2.1",[97],{"text":98,"refs":101},{"fa":99,"en":100},"افزایش وزن و دیس‌لیپیدمی در نوجوانان بیشتر است؛ ممکن است داروهای دیگر اول انتخاب شوند.","Weight gain and dyslipidemia are greater in adolescents; other drugs may be considered first.",[102],{"source":34,"section":103},"1.1",{"id":105,"disease":79,"label":106,"population":109,"type":89,"unit":29,"dose":111,"refs":113},"schizo-adult",{"fa":107,"en":108},"اسکیزوفرنی — بزرگسال: ۵ تا ۱۰ mg، هدف ۱۰","Schizophrenia — adults: 5–10 mg, target 10",{"minAge":110},{"value":88,"unit":86},{"dividedDoses":5,"titration":112},{"start":40,"increment":40,"incrementEveryDays":92,"targetMin":56,"targetMax":56,"max":72},[114],{"source":34,"section":95},{"id":116,"disease":117,"label":118,"population":121,"type":89,"unit":29,"dose":123,"refs":125},"bipolar-adult","bipolar-mania",{"fa":119,"en":120},"مانیای دوقطبی — بزرگسال: شروع ۱۰ یا ۱۵ mg","Bipolar mania — adults: start 10 or 15 mg",{"minAge":122},{"value":88,"unit":86},{"dividedDoses":5,"titration":124},{"start":56,"increment":40,"incrementEveryDays":5,"targetMin":56,"targetMax":64,"max":72},[126],{"source":34,"section":127},"2.2",[],[],[],[],[],{"status":134,"reviewer":135,"date":135},"unverified",null,[137,141,146],{"regimen":78,"formulation":23,"input":138,"expect":140},{"ageYears":64,"weightKg":139},55,{"perDose":28},{"regimen":105,"formulation":37,"input":142,"expect":145},{"ageYears":143,"weightKg":144},30,70,{"perDose":40},{"regimen":116,"formulation":53,"input":147,"expect":148},{"ageYears":143,"weightKg":144},{"perDose":56},[150],"N05AH03",{"status":152,"forms":153,"refs":174},"registered",[154,158,162,166,170],{"code":155,"en":156,"fa":157},"02035","OLANZAPINE 10MG TAB","قرص اولانزاپین ۱۰ میلی‌گرم",{"code":159,"en":160,"fa":161},"02746","OLANZAPINE 15MG TAB","قرص اولانزاپین ۱۵ میلی‌گرم",{"code":163,"en":164,"fa":165},"02751","OLANZAPINE 2.5MG TAB","قرص اولانزاپین ۲٫۵ میلی‌گرم",{"code":167,"en":168,"fa":169},"01907","OLANZAPINE 5MG TAB","قرص اولانزاپین ۵ میلی‌گرم",{"code":171,"en":172,"fa":173},"50393","OLANZAPINE 10 MG INJ","فرآورده تزریقی اولانزاپین ۱۰ میلی‌گرم",[175],{"source":176,"section":177,"url":178},"darooyab-generic","G-1315\u002FOlanzapine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1315\u002FOlanzapine",[180,184,188,191,194,197],{"kind":181,"url":182,"label":183},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020592","NDA020592",{"kind":185,"url":186,"label":187},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b418946a-1ab4-4d89-a012-d94fc361a3c4","FDA Zyprexa",{"kind":189,"url":190,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601213.html",{"kind":189,"url":192,"label":193},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa614016.html","Olanzapine Injection",{"kind":195,"url":196,"label":150},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AH03",{"kind":198,"url":178,"label":8},"darooyab",{"pregnancy":200,"lactation":209,"pediatric":217,"geriatric":225,"reproductive":234},{"level":201,"text":202,"quote":205,"refs":206},"caution",{"fa":203,"en":204},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates exposed to antipsychotic drugs, including ZYPREXA, during the third trimester are at risk for extrapyramidal and\u002For withdrawal symptoms following delivery (see Clinical Considerations) .",[207],{"source":34,"section":208},"8.1",{"level":201,"text":210,"quote":213,"refs":214},{"fa":211,"en":212},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Olanzapine is present in human milk.",[215],{"source":34,"section":216},"8.2",{"level":201,"text":218,"quote":221,"refs":222},{"fa":219,"en":220},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Safety and efficacy of ZYPREXA and fluoxetine in combination in children and adolescents (10 to 17 years of age) have been established for the acute treatment of depressive episodes associated with bipolar I disorder.",[223],{"source":34,"section":224},"8.4",{"level":226,"text":227,"quote":230,"refs":231},"avoid",{"fa":228,"en":229},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.",[232],{"source":34,"section":233},"Boxed Warning",{"level":201,"text":235,"quote":238,"refs":239},{"fa":236,"en":237},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Females Based on the pharmacologic action of olanzapine (D 2 receptor antagonism), treatment with ZYPREXA may result in an increase in serum prolactin levels, which may lead to a reversible reduction in fertility in females of reproductive potential [see Warnings and Precautions ( 5.15 )] .",[240],{"source":34,"section":241},"8.3",{"kind":243,"refs":244,"id":183},"NDA",[245],{"source":34,"section":246},"SPL approval \u002F marketing category",1792440737203]