[{"data":1,"prerenderedAt":206},["ShallowReactive",2],{"drug-pemetrexed":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":88,"warnings":98,"renal":106,"monitoring":115,"interactions":116,"review":117,"examples":120,"atc":131,"iran":133,"links":140,"populations":156,"usApproval":201},"pemetrexed",1,{"fa":7,"en":8},"پمترکسد","Pemetrexed","antineoplastic-immunomodulating",{"fa":11,"en":12},"آنتی‌متابولیت آنتی‌فولات","Antifolate antimetabolite",[14],{"name":15,"market":16},"Alimta","US",[18,19,7],"alimta","آلیمتا",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"vial-500","powder-for-injection","iv","500 mg vial (also 100 mg)",{"amount":27,"unit":28,"perUnit":29},500,"mg","vial",[16],[32],{"source":33,"section":34},"fda-alimta","3",[36,66],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":48,"durationDays":51,"notes":52},"nsclc","lung-cancer",{"fa":40,"en":41},"سرطان ریه غیرسلول کوچک غیرسنگفرشی — ۵۰۰ mg\u002Fm² وریدی ۱۰ دقیقه، روز ۱ هر ۲۱ روز","Non-squamous NSCLC — 500 mg\u002Fm² IV over 10 min on day 1 every 21 days",{"minAge":43},{"value":44,"unit":45},18,"year","bsa",{"perM2PerDay":27,"dividedDoses":5},[49],{"source":33,"section":50},"2.1",{"min":5,"max":5},[53,59],{"text":54,"refs":57},{"fa":55,"en":56},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[58],{"source":33,"section":50},{"text":60,"refs":63},{"fa":61,"en":62},"پیش‌درمان: اسید فولیک ۴۰۰ تا ۱۰۰۰ mcg روزانه از ۷ روز قبل، ویتامین B12 عضلانی هر ۹ هفته، دگزامتازون ۴ mg دو بار در روز قبل، روز و بعد از تزریق.","Premedication: folic acid 400–1000 mcg daily from 7 days before, vitamin B12 IM every 9 weeks, dexamethasone 4 mg twice daily the day before, of and after.",[64],{"source":33,"section":65},"2.4",{"id":67,"disease":68,"label":69,"population":72,"type":46,"unit":28,"dose":74,"refs":75,"durationDays":78,"notes":79},"meso","mesothelioma",{"fa":70,"en":71},"مزوتلیومای پلور (با سیس‌پلاتین) — ۵۰۰ mg\u002Fm² روز ۱ هر ۲۱ روز","Pleural mesothelioma (with cisplatin) — 500 mg\u002Fm² on day 1 every 21 days",{"minAge":73},{"value":44,"unit":45},{"perM2PerDay":27,"dividedDoses":5},[76],{"source":33,"section":77},"2.2",{"min":5,"max":5},[80,84],{"text":81,"refs":82},{"fa":55,"en":56},[83],{"source":33,"section":77},{"text":85,"refs":86},{"fa":61,"en":62},[87],{"source":33,"section":65},[89],{"id":90,"severity":91,"text":92,"refs":95},"hyper","block",{"fa":93,"en":94},"سابقه واکنش حساسیتی شدید به پمترکسد.","History of severe hypersensitivity to pemetrexed.",[96],{"source":33,"section":97},"4",[99],{"text":100,"refs":103},{"fa":101,"en":102},"سرکوب مغز استخوان (کمتر با فولات و B12)؛ نارسایی کلیه؛ واکنش پوستی تاولی؛ پنومونیت بینابینی؛ تداخل با ایبوپروفن؛ سمیت جنینی.","Myelosuppression (reduced with folate and B12); renal failure; bullous skin toxicity; interstitial pneumonitis; ibuprofen interaction; embryo-fetal toxicity.",[104],{"source":33,"section":105},"5",[107],{"egfrBelow":108,"severity":91,"text":109,"refs":112},45,{"fa":110,"en":111},"ClCr زیر ۴۵: دوز توصیه‌شده‌ای نیست — تجویز نشود.","CrCl below 45: no recommended dose — do not give.",[113],{"source":33,"section":114},"2.3",[],[],{"status":118,"reviewer":119,"date":119},"unverified",null,[121,128],{"regimen":37,"formulation":22,"input":122,"expect":126},{"ageYears":123,"weightKg":124,"heightCm":125},55,80,180,{"perDose":127},1000,{"regimen":67,"formulation":22,"input":129,"expect":130},{"ageYears":123,"weightKg":124,"heightCm":125},{"perDose":127},[132],"L01BA04",{"status":134,"refs":135},"not-found",[136],{"source":137,"section":138,"url":139},"darooyab-generic","search","https:\u002F\u002Fwww.darooyab.ir\u002FSearch?q=Pemetrexed",[141,145,149,153],{"kind":142,"url":143,"label":144},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=021462","NDA021462",{"kind":146,"url":147,"label":148},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f5a860f3-37ec-429c-ae04-9c88d7c55c08","FDA Alimta",{"kind":150,"url":151,"label":152},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa607043.html","Pemetrexed Injection",{"kind":154,"url":155,"label":132},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01BA04",{"pregnancy":157,"lactation":166,"pediatric":174,"geriatric":183,"reproductive":192},{"level":158,"text":159,"quote":162,"refs":163},"avoid",{"fa":160,"en":161},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on findings from animal studies and its mechanism of action, ALIMTA can cause fetal harm when administered to a pregnant woman [see Clinical Pharmacology ( 12.1 )] .",[164],{"source":33,"section":165},"8.1",{"level":158,"text":167,"quote":170,"refs":171},{"fa":168,"en":169},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in breastfed infants from ALIMTA, advise women not to breastfeed during treatment with ALIMTA and for one week after the last dose.",[172],{"source":33,"section":173},"8.2",{"level":175,"text":176,"quote":179,"refs":180},"not-established",{"fa":177,"en":178},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of ALIMTA in pediatric patients have not been established.",[181],{"source":33,"section":182},"8.4",{"level":184,"text":185,"quote":188,"refs":189},"ok",{"fa":186,"en":187},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","No overall differences in effectiveness were observed between these patients and younger patients.",[190],{"source":33,"section":191},"8.5",{"level":193,"text":194,"quote":197,"refs":198},"caution",{"fa":195,"en":196},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Contraception Females Because of the potential for genotoxicity, advise females of reproductive potential to use effective contraception during treatment with ALIMTA and for 6 months after the last dose.",[199],{"source":33,"section":200},"8.3",{"kind":202,"refs":203,"id":144},"NDA",[204],{"source":33,"section":205},"SPL approval \u002F marketing category",1792444707651]