[{"data":1,"prerenderedAt":240},["ShallowReactive",2],{"drug-phenytoin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":48,"contraindications":100,"warnings":110,"renal":111,"monitoring":112,"interactions":113,"review":114,"examples":117,"atc":128,"iran":130,"links":178,"populations":201,"usApproval":235},"phenytoin",1,{"fa":7,"en":8},"فنی‌توئین","Phenytoin","nervous-system",{"fa":11,"en":12},"ضدتشنج هیدانتوئین","Hydantoin anticonvulsant",[14],{"name":15,"market":16},"Dilantin","US",[18,19,20,21],"dilantin","دیلانتین","فنی توئین","فنیتوئین",[23,37],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"cap-100","capsule","oral","100 mg extended-release capsule",{"amount":29,"unit":30,"perUnit":25,"scored":31},100,"mg",false,[16],[34],{"source":35,"section":36},"fda-phenytoin","3",{"id":38,"form":39,"route":26,"label":40,"concentration":41,"markets":44,"refs":45},"susp-125","suspension","125 mg\u002F5 mL oral suspension",{"amount":42,"unit":30,"perVolumeMl":43},125,5,[16],[46],{"source":47,"section":36},"fda-phenytoin-susp",[49,76],{"id":50,"disease":51,"label":52,"population":55,"type":59,"unit":30,"dose":60,"refs":62,"notes":67},"adult","epilepsy",{"fa":53,"en":54},"صرع — بزرگسال: ۱۰۰ mg سه بار در روز","Epilepsy — adults: 100 mg three times daily",{"minAge":56},{"value":57,"unit":58},18,"year","fixed",{"perDose":29,"dosesPerDay":61},3,[63,65],{"source":35,"section":64},"2.1",{"source":47,"section":66},"2.2",[68],{"text":69,"refs":72},{"fa":70,"en":71},"اگر با ۱۰۰ mg سه بار کنترل شد، می‌توان ۳۰۰ mg یک بار (فقط کپسول آهسته‌رهش). سطح سرمی ممکن است لازم باشد. سوسپانسیون: حداکثر ۲۵ mL\u002Fday.","If controlled on 100 mg tid, 300 mg once daily may be considered (extended capsules only). Serum levels may be needed. Suspension: max 25 mL\u002Fday.",[73,75],{"source":35,"section":74},"2",{"source":47,"section":66},{"id":77,"disease":51,"label":78,"population":81,"type":83,"unit":30,"dose":84,"refs":86,"limits":88,"notes":92},"peds",{"fa":79,"en":80},"صرع — کودکان: ۵ mg\u002Fkg\u002Fday در ۲ یا ۳ نوبت","Epilepsy — children: 5 mg\u002Fkg\u002Fday in 2 or 3 doses",{"maxAge":82},{"value":57,"unit":58},"weightBased",{"perKgPerDay":43,"dividedDoses":85},2,[87],{"source":35,"section":66},{"maxPerDay":89,"refs":90},300,[91],{"source":35,"section":66},[93],{"text":94,"refs":97},{"fa":95,"en":96},"نگهدارنده ۴ تا ۸ mg\u002Fkg\u002Fday؛ حداکثر ۳۰۰ mg\u002Fday. بالای ۶ سال ممکن است حداقل دوز بزرگسال (۳۰۰) لازم باشد.","Maintenance 4–8 mg\u002Fkg\u002Fday; max 300 mg\u002Fday. Over 6 years may need the minimum adult dose (300).",[98,99],{"source":35,"section":66},{"source":35,"section":74},[101],{"id":102,"severity":103,"text":104,"refs":107},"ci","block",{"fa":105,"en":106},"حساسیت به فنی‌توئین یا سایر هیدانتوئین‌ها؛ سابقه هپاتوتوکسیسیتی حاد با فنی‌توئین؛ همراه دلاویردین.","Hypersensitivity to phenytoin or other hydantoins; prior acute phenytoin hepatotoxicity; with delavirdine.",[108],{"source":35,"section":109},"4",[],[],[],[],{"status":115,"reviewer":116,"date":116},"unverified",null,[118,123],{"regimen":50,"formulation":24,"input":119,"expect":122},{"ageYears":120,"weightKg":121},30,70,{"perDose":29,"perDay":89},{"regimen":77,"formulation":38,"input":124,"expect":126},{"ageYears":43,"weightKg":125},20,{"perDose":127,"mlPerDose":85},50,[129],"N03AB02",{"status":131,"forms":132,"refs":173},"registered",[133,137,141,145,149,153,157,161,165,169],{"code":134,"en":135,"fa":136},"06202","PHENYTOIN 100MG TAB","قرص فنی‌توئین ۱۰۰ میلی‌گرم",{"code":138,"en":139,"fa":140},"00994","PHENYTOIN 125MG\u002F5ML SUSP","سوسپانسیون فنی‌توئین ۱۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":142,"en":143,"fa":144},"06072","PHENYTOIN 30MG\u002F5ML 120ML SUSP","سوسپانسیون فنی‌توئین ۳۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":146,"en":147,"fa":148},"09960","PHENYTOIN 30MG\u002F5ML 500ML SUSP","سوسپانسیون فنی‌توئین ۳۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۵۰۰ میلی‌لیتر",{"code":150,"en":151,"fa":152},"00997","PHENYTOIN SODIUM 1% 30G CREAM","کرم فنی‌توئین سدیم ۱ درصد ۳۰ گرم",{"code":154,"en":155,"fa":156},"00993","PHENYTOIN SODIUM 100MG CAP","کپسول فنی‌توئین سدیم ۱۰۰ میلی‌گرم",{"code":158,"en":159,"fa":160},"20315","PHENYTOIN SODIUM 100MG TAB","قرص فنی‌توئین سدیم ۱۰۰ میلی‌گرم",{"code":162,"en":163,"fa":164},"00995","PHENYTOIN SODIUM 250MG\u002F5ML AMP","آمپول فنی‌توئین سدیم ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":166,"en":167,"fa":168},"01637","PHENYTOIN SODIUM 50MG CAP","کپسول فنی‌توئین سدیم ۵۰ میلی‌گرم",{"code":170,"en":171,"fa":172},"52698","PHENYTOIN SUSPENSION ORAL 30 mg\u002F5mL 200 mL","سوسپانسیون خوراکی فنی‌توئین ۳۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۰۰ میلی‌لیتر",[174],{"source":175,"section":176,"url":177},"darooyab-generic","G-679\u002FPhenytoin","https:\u002F\u002Fwww.darooyab.ir\u002FG-679\u002FPhenytoin",[179,183,187,190,193,196,199],{"kind":180,"url":181,"label":182},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040684","ANDA040684",{"kind":184,"url":185,"label":186},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=46d5c0d1-a97b-46d9-8cf4-994780673337","FDA Phenytoin ER",{"kind":184,"url":188,"label":189},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=093fd736-5971-47af-b4ef-08c1696cebe8","FDA Phenytoin susp",{"kind":191,"url":192,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682022.html",{"kind":191,"url":194,"label":195},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa619062.html","Phenytoin Injection",{"kind":197,"url":198,"label":129},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N03AB02",{"kind":200,"url":177,"label":8},"darooyab",{"pregnancy":202,"lactation":211,"pediatric":219,"geriatric":227},{"level":203,"text":204,"quote":207,"refs":208},"caution",{"fa":205,"en":206},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Information on the registry can also be found at the website http:\u002F\u002Fwww.aedpregnancyregistry.org\u002F Risk Summary In humans, prenatal exposure to phenytoin may increase the risks for congenital malformations and other adverse developmental outcomes.",[209],{"source":35,"section":210},"8.1",{"level":203,"text":212,"quote":215,"refs":216},{"fa":213,"en":214},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Phenytoin is secreted in human milk.",[217],{"source":35,"section":218},"8.2",{"level":203,"text":220,"quote":223,"refs":224},{"fa":221,"en":222},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Initially, 5 mg\u002Fkg\u002Fday in two or three equally divided doses, with subsequent dosage individualized to a maximum of 300 mg daily.",[225],{"source":35,"section":226},"8.4",{"level":203,"text":228,"quote":231,"refs":232},{"fa":229,"en":230},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Phenytoin clearance tends to decrease with increasing age [see Clinical Pharmacology (12.3) ] .",[233],{"source":35,"section":234},"8.5",{"kind":236,"refs":237,"id":182},"ANDA",[238],{"source":35,"section":239},"SPL approval \u002F marketing category",1792444712095]