[{"data":1,"prerenderedAt":209},["ShallowReactive",2],{"drug-pioglitazone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":51,"contraindications":97,"warnings":107,"renal":108,"monitoring":109,"interactions":110,"review":111,"examples":114,"atc":120,"iran":122,"links":142,"populations":162,"usApproval":204},"pioglitazone",1,{"fa":7,"en":8},"پیوگلیتازون","Pioglitazone","alimentary-metabolism",{"fa":11,"en":12},"تیازولیدین‌دیون","Thiazolidinedione",[14],{"name":15,"market":16},"Actos","US",[18,19,7],"actos","اکتوس",[21,35,43],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-15","tablet","oral","15 mg tablet",{"amount":27,"unit":28,"perUnit":23,"scored":29},15,"mg",false,[16],[32],{"source":33,"section":34},"fda-pioglitazone","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"tab-30","30 mg tablet",{"amount":39,"unit":28,"perUnit":23,"scored":29},30,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"tab-45","45 mg tablet",{"amount":47,"unit":28,"perUnit":23,"scored":29},45,[16],[50],{"source":33,"section":34},[52,82],{"id":53,"disease":54,"label":55,"population":58,"type":62,"unit":28,"dose":63,"refs":64,"limits":70,"notes":73},"adult","type-2-diabetes",{"fa":56,"en":57},"دیابت نوع ۲ — شروع ۱۵ یا ۳۰ mg یک بار در روز","Type 2 diabetes — start 15 or 30 mg once daily",{"minAge":59},{"value":60,"unit":61},18,"year","fixed",{"perDose":27,"perDoseMax":39,"dosesPerDay":5},[65,68],{"source":66,"section":67},"fda-pioglitazone-b","2.1",{"source":66,"section":69},"2",{"maxPerDay":47,"refs":71},[72],{"source":66,"section":69},[74],{"text":75,"refs":78},{"fa":76,"en":77},"نارسایی قلبی NYHA I–II: شروع ۱۵ mg. افزایش ۱۵ mg تا حداکثر ۴۵. با جم‌فیبروزیل یا مهارکننده قوی CYP2C8 حداکثر ۱۵ mg.","NYHA I–II heart failure: start 15 mg. Increase by 15 mg up to 45. With gemfibrozil or strong CYP2C8 inhibitors max 15 mg.",[79,80],{"source":66,"section":69},{"source":66,"section":81},"2.3",{"id":83,"disease":54,"label":84,"population":87,"type":89,"unit":28,"dose":90,"refs":94},"peds",{"fa":85,"en":86},"زیر ۱۸ سال","Under 18 years",{"maxAge":88},{"value":60,"unit":61},"notCalculated",{"reason":91},{"fa":92,"en":93},"در کودکان توصیه نمی‌شود.","Not recommended in children.",[95],{"source":66,"section":96},"8.4",[98],{"id":99,"severity":100,"text":101,"refs":104},"hf","block",{"fa":102,"en":103},"هشدار جعبه‌ای: شروع در نارسایی قلبی NYHA III یا IV ممنوع است.","Boxed warning: initiation in NYHA class III or IV heart failure is contraindicated.",[105],{"source":66,"section":106},"Boxed Warning",[],[],[],[],{"status":112,"reviewer":113,"date":113},"unverified",null,[115],{"regimen":53,"formulation":22,"input":116,"expect":119},{"ageYears":117,"weightKg":118},55,80,{"perDose":27,"upperPerDose":39},[121],"A10BG03",{"status":123,"forms":124,"refs":137},"registered",[125,129,133],{"code":126,"en":127,"fa":128},"05624","PIOGLITAZONE 15MG TAB","قرص پیوگلیتازون ۱۵ میلی‌گرم",{"code":130,"en":131,"fa":132},"05217","PIOGLITAZONE 30MG TAB","قرص پیوگلیتازون ۳۰ میلی‌گرم",{"code":134,"en":135,"fa":136},"05625","PIOGLITAZONE 45MG TAB","قرص پیوگلیتازون ۴۵ میلی‌گرم",[138],{"source":139,"section":140,"url":141},"darooyab-generic","G-646\u002FPioglitazone","https:\u002F\u002Fwww.darooyab.ir\u002FG-646\u002FPioglitazone",[143,147,151,154,157,160],{"kind":144,"url":145,"label":146},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=200268","ANDA200268",{"kind":148,"url":149,"label":150},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=04577c39-a9c0-4c66-a775-4c79e2c3dea5","FDA Pioglitazone (2)",{"kind":148,"url":152,"label":153},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=31619517-a590-408a-ae9e-76c99f0a0a1d","FDA Pioglitazone",{"kind":155,"url":156,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699016.html",{"kind":158,"url":159,"label":121},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A10BG03",{"kind":161,"url":141,"label":8},"darooyab",{"pregnancy":163,"lactation":172,"pediatric":180,"geriatric":188,"reproductive":196},{"level":164,"text":165,"quote":168,"refs":169},"caution",{"fa":166,"en":167},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Limited data with pioglitazone in pregnant women are not sufficient to determine a drug-associated risk for major birth defects or miscarriage.",[170],{"source":66,"section":171},"8.1",{"level":164,"text":173,"quote":176,"refs":177},{"fa":174,"en":175},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There is no information regarding the presence of pioglitazone in human milk, the effects on the breastfed infant, or the effects on milk production.",[178],{"source":66,"section":179},"8.2",{"level":181,"text":182,"quote":185,"refs":186},"not-established",{"fa":183,"en":184},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of pioglitazone in pediatric patients have not been established.",[187],{"source":66,"section":96},{"level":164,"text":189,"quote":192,"refs":193},{"fa":190,"en":191},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","A total of 92 patients (15.2%) treated with pioglitazone in the three pooled 16- to 26-week double-blind, placebo-controlled, monotherapy trials were ≥65 years old and two patients (0.3%) were ≥75 years old.",[194],{"source":66,"section":195},"8.5",{"level":164,"text":197,"quote":200,"refs":201},{"fa":198,"en":199},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Discuss the potential for unintended pregnancy with premenopausal women as therapy with pioglitazone, like other thiazolidinediones, may result in ovulation in some anovulatory women.",[202],{"source":66,"section":203},"8.3",{"kind":205,"refs":206,"id":146},"ANDA",[207],{"source":66,"section":208},"SPL approval \u002F marketing category",1792191865847]