[{"data":1,"prerenderedAt":187},["ShallowReactive",2],{"drug-promethazine-injection":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":34,"contraindications":60,"warnings":80,"renal":81,"monitoring":82,"interactions":83,"review":84,"examples":87,"atc":94,"iran":96,"links":128,"populations":146,"usApproval":182},"promethazine-injection",1,{"fa":7,"en":8},"پرومتازین (آمپول)","Promethazine (injection)","respiratory",{"fa":11,"en":12},"آنتی‌هیستامین فنوتیازینی","Phenothiazine antihistamine",[14],{"name":15,"market":16},"Phenergan injection","US",[18,19],"آمپول پرومتازین","phenergan",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":29,"refs":30},"inj-25","injection","im","25 mg\u002FmL injection",{"amount":27,"unit":28,"perVolumeMl":5},25,"mg",[16],[31],{"source":32,"section":33},"fda-promethazineinj","How Supplied",[35],{"id":36,"disease":37,"label":38,"population":41,"type":45,"unit":28,"dose":46,"refs":49,"notes":52},"nv","nausea-vomiting",{"fa":39,"en":40},"تهوع و استفراغ — بزرگسال: ۱۲٫۵ تا ۲۵ mg، نه زودتر از هر ۴ ساعت","Nausea\u002Fvomiting — adults: 12.5–25 mg, not more often than every 4 h",{"minAge":42},{"value":43,"unit":44},18,"year","fixed",{"perDose":47,"perDoseMax":27,"dosesPerDay":48,"intervalHours":48},12.5,4,[50],{"source":32,"section":51},"Dosage and Administration",[53],{"text":54,"refs":57},{"fa":55,"en":56},"ترجیحاً عضلانی عمیق؛ تزریق وریدی خطر آسیب شدید بافتی دارد.","Preferably deep IM; IV use risks severe tissue injury.",[58],{"source":32,"section":59},"Boxed Warning",[61,72],{"id":62,"severity":63,"rule":64,"text":67,"refs":70},"under-2","block",{"maxAge":65},{"value":66,"unit":44},2,{"fa":68,"en":69},"زیر ۲ سال منع مصرف (دپرسیون تنفسی کشنده).","Contraindicated under 2 years (fatal respiratory depression).",[71],{"source":32,"section":59},{"id":73,"severity":74,"text":75,"refs":78},"boxed","warn",{"fa":76,"en":77},"هشدار جعبه‌ای: آسیب شدید بافتی و گانگرن با تزریق نادرست؛ دپرسیون تنفسی در کودکان.","Boxed warning: severe tissue injury and gangrene with improper injection; respiratory depression in children.",[79],{"source":32,"section":59},[],[],[],[],{"status":85,"reviewer":86,"date":86},"unverified",null,[88],{"regimen":36,"formulation":22,"input":89,"expect":92},{"ageYears":90,"weightKg":91},40,70,{"perDose":47,"mlPerDose":93,"upperPerDose":27},0.5,[95],"R06AD02",{"status":97,"forms":98,"refs":123},"registered",[99,103,107,111,115,119],{"code":100,"en":101,"fa":102},"10253","PROMETHAZINE 10MG TAB","قرص پرومتازین ۱۰ میلی‌گرم",{"code":104,"en":105,"fa":106},"02095","PROMETHAZINE 25MG\u002FML 1ML AMP","آمپول پرومتازین ۲۵ میلی‌گرم \u002F میلی‌لیتر ۱ میلی‌لیتر",{"code":108,"en":109,"fa":110},"01061","PROMETHAZINE 50MG\u002F2ML AMP","آمپول پرومتازین ۵۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":112,"en":113,"fa":114},"01060","PROMETHAZINE 5MG\u002F5ML 60ML SYRUP","شربت پرومتازین ۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":116,"en":117,"fa":118},"01062","PROMETHAZINE HCL 25MG TAB","قرص پرومتازین هیدروکلراید ۲۵ میلی‌گرم",{"code":120,"en":121,"fa":122},"50433","PROMETHAZINE HYDROCHLORIDE INJECTION PARENTERAL 25 mg\u002F1mL 2 mL","فرآورده تزریقی پرومتازین هیدروکلراید ۲۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۲ میلی‌لیتر",[124],{"source":125,"section":126,"url":127},"darooyab-generic","G-822\u002FPromethazine","https:\u002F\u002Fwww.darooyab.ir\u002FG-822\u002FPromethazine",[129,133,137,141,144],{"kind":130,"url":131,"label":132},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=083312","ANDA083312",{"kind":134,"url":135,"label":136},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=38673af1-112e-9ddd-e063-6294a90af465","FDA Promethazine inj.",{"kind":138,"url":139,"label":140},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682284.html","Promethazine",{"kind":142,"url":143,"label":95},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R06AD02",{"kind":145,"url":127,"label":140},"darooyab",{"pregnancy":147,"lactation":156,"pediatric":165,"geriatric":174},{"level":148,"text":149,"quote":152,"refs":153},"caution",{"fa":150,"en":151},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.",[154],{"source":32,"section":155},"Pregnancy Tests",{"level":157,"text":158,"quote":161,"refs":162},"avoid",{"fa":159,"en":160},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk, and because of the potential for serious adverse reactions in nursing infants from promethazine hydrochloride injection, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[163],{"source":32,"section":164},"Nursing Mothers",{"level":166,"text":167,"quote":170,"refs":171},"contraindicated",{"fa":168,"en":169},"برچسب: در کودکان زیر سن مشخص منع مصرف دارد.","Label: contraindicated in children below a stated age.","The use of promethazine hydrochloride injection is contraindicated: In pediatric patients less than 2 years of age due to the risk of respiratory depression (see WARNINGS – Respiratory Depression ).",[172],{"source":32,"section":173},"CONTRAINDICATIONS",{"level":148,"text":175,"quote":178,"refs":179},{"fa":176,"en":177},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Since therapeutic requirements for sedative drugs tend to be less in geriatric patients, the dosage should be reduced for these patients.",[180],{"source":32,"section":181},"Geriatric Use (patients approximately 60 years or older)",{"kind":183,"refs":184,"id":132},"ANDA",[185],{"source":32,"section":186},"SPL approval \u002F marketing category",1792191881309]