[{"data":1,"prerenderedAt":289},["ShallowReactive",2],{"drug-promethazine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":47,"contraindications":140,"warnings":161,"renal":162,"monitoring":163,"interactions":164,"review":165,"examples":168,"atc":196,"iran":198,"links":230,"populations":250,"usApproval":284},"promethazine",1,{"fa":7,"en":8},"پرومتازین","Promethazine","respiratory",{"fa":11,"en":12},"آنتی‌هیستامین فنوتیازینی","Phenothiazine antihistamine",[14],{"name":15,"market":16},"Phenergan","US",[18,19,7,20],"phenergan","فنرگان","پرومتازین ۲۵",[22,36],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-25","tablet","oral","25 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},25,"mg",true,[16],[33],{"source":34,"section":35},"fda-promethazine","How Supplied",{"id":37,"form":38,"route":25,"label":39,"concentration":40,"markets":43,"refs":44},"syr-6-25","syrup","6.25 mg \u002F 5 mL syrup",{"amount":41,"unit":29,"perVolumeMl":42},6.25,5,[16],[45],{"source":46,"section":35},"fda-promethazinesol",[48,70,82,94,114],{"id":49,"disease":50,"label":51,"population":54,"type":58,"unit":29,"dose":59,"refs":60,"notes":63},"allergy","allergic-conditions",{"fa":52,"en":53},"آلرژی — ۲۵ mg هنگام خواب","Allergy — 25 mg at bedtime",{"minAge":55},{"value":56,"unit":57},18,"year","fixed",{"perDose":28,"dosesPerDay":5},[61],{"source":34,"section":62},"Dosage and Administration",[64],{"text":65,"refs":68},{"fa":66,"en":67},"یا ۱۲٫۵ mg قبل از غذا و هنگام خواب؛ یا ۶٫۲۵ تا ۱۲٫۵ mg سه بار.","Or 12.5 mg before meals and at bedtime; or 6.25–12.5 mg three times daily.",[69],{"source":34,"section":62},{"id":71,"disease":72,"label":73,"population":76,"type":58,"unit":29,"dose":78,"refs":80},"motion","motion-sickness",{"fa":74,"en":75},"بیماری حرکت — بزرگسال: ۲۵ mg دو بار در روز","Motion sickness — adults: 25 mg twice daily",{"minAge":77},{"value":56,"unit":57},{"perDose":28,"dosesPerDay":79},2,[81],{"source":34,"section":62},{"id":83,"disease":72,"label":84,"population":87,"type":58,"unit":29,"dose":90,"refs":92},"motion-child",{"fa":85,"en":86},"بیماری حرکت — کودک ۲ سال به بالا: ۱۲٫۵ تا ۲۵ mg دو بار","Motion sickness — child ≥2 y: 12.5–25 mg twice daily",{"minAge":88,"maxAge":89},{"value":79,"unit":57},{"value":56,"unit":57},{"perDose":91,"perDoseMax":28,"dosesPerDay":79},12.5,[93],{"source":34,"section":62},{"id":95,"disease":96,"label":97,"population":100,"type":58,"unit":29,"dose":102,"refs":105,"notes":107},"nv-adult","nausea-vomiting",{"fa":98,"en":99},"تهوع و استفراغ — بزرگسال: ۲۵ mg","Nausea and vomiting — adults: 25 mg",{"minAge":101},{"value":56,"unit":57},{"perDose":28,"dosesPerDay":103,"intervalHours":104},4,6,[106],{"source":34,"section":62},[108],{"text":109,"refs":112},{"fa":110,"en":111},"پیشگیری (مثلاً پس از جراحی): ۲۵ mg هر ۴ تا ۶ ساعت در صورت نیاز.","Prophylaxis (e.g. postoperative): 25 mg every 4–6 h as needed.",[113],{"source":34,"section":62},{"id":115,"disease":96,"label":116,"population":119,"type":122,"unit":29,"dose":123,"refs":125,"limits":127,"notes":133},"nv-child",{"fa":117,"en":118},"تهوع و استفراغ — کودک ۲ سال به بالا: ۰٫۵ mg\u002Fپوند (≈۱٫۱ mg\u002Fkg)","Nausea and vomiting — child ≥2 y: 0.5 mg\u002Flb (≈1.1 mg\u002Fkg)",{"minAge":120,"maxAge":121},{"value":79,"unit":57},{"value":56,"unit":57},"weightBased",{"perKgPerDose":124,"intervalHours":104},1.1,[126],{"source":34,"section":62},{"maxPerDose":28,"refs":128},[129],{"source":34,"section":62,"note":130},{"fa":131,"en":132},"Doz دوز مؤثر متوسط (۲۵ mg) را سقف هر دوز گرفته؛ برچسب آن را حداکثر نگفته","Doz uses the average adult\u002Fchild effective dose (25 mg) as a per-dose ceiling; not stated as a maximum",[134],{"text":135,"refs":138},{"fa":136,"en":137},"۰٫۵ mg به‌ازای هر پوند؛ تبدیل به mg\u002Fkg را Doz انجام داده. در استفراغ با علت نامعلوم در کودکان استفاده نشود.","0.5 mg per pound; conversion to mg\u002Fkg done by Doz. Do not use for vomiting of unknown cause in children.",[139],{"source":34,"section":62},[141,154],{"id":142,"severity":143,"rule":144,"text":146,"refs":149},"under-2","block",{"maxAge":145},{"value":79,"unit":57},{"fa":147,"en":148},"هشدار جعبه‌ای: زیر ۲ سال منع مصرف (دپرسیون تنفسی کشنده).","Boxed warning: contraindicated under 2 years (fatal respiratory depression).",[150,152],{"source":34,"section":151},"Contraindications",{"source":34,"section":153},"Boxed Warning",{"id":155,"severity":143,"text":156,"refs":159},"ci",{"fa":157,"en":158},"کما؛ حساسیت به فنوتیازین‌ها؛ درمان علائم تنفسی تحتانی از جمله آسم.","Coma; hypersensitivity to phenothiazines; lower respiratory symptoms including asthma.",[160],{"source":34,"section":151},[],[],[],[],{"status":166,"reviewer":167,"date":167},"unverified",null,[169,174,178,183,186,191],{"regimen":49,"formulation":23,"input":170,"expect":173},{"ageYears":171,"weightKg":172},30,70,{"perDose":28},{"regimen":71,"formulation":23,"input":175,"expect":176},{"ageYears":171,"weightKg":172},{"perDay":177},50,{"regimen":83,"formulation":23,"input":179,"expect":181},{"ageYears":180,"weightKg":28},8,{"perDose":91,"tabletsPerDoseRounded":182},0.5,{"regimen":95,"formulation":23,"input":184,"expect":185},{"ageYears":171,"weightKg":172},{"perDose":28},{"regimen":115,"formulation":23,"input":187,"expect":189},{"ageYears":42,"weightKg":188},11.5,{"perDose":190,"tabletsPerDoseRounded":182},12.65,{"regimen":115,"formulation":23,"input":192,"expect":195},{"ageYears":193,"weightKg":194},12,40,{"perDose":28},[197],"R06AD02",{"status":199,"forms":200,"refs":225},"registered",[201,205,209,213,217,221],{"code":202,"en":203,"fa":204},"10253","PROMETHAZINE 10MG TAB","قرص پرومتازین ۱۰ میلی‌گرم",{"code":206,"en":207,"fa":208},"02095","PROMETHAZINE 25MG\u002FML 1ML AMP","آمپول پرومتازین ۲۵ میلی‌گرم \u002F میلی‌لیتر ۱ میلی‌لیتر",{"code":210,"en":211,"fa":212},"01061","PROMETHAZINE 50MG\u002F2ML AMP","آمپول پرومتازین ۵۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":214,"en":215,"fa":216},"01060","PROMETHAZINE 5MG\u002F5ML 60ML SYRUP","شربت پرومتازین ۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",{"code":218,"en":219,"fa":220},"01062","PROMETHAZINE HCL 25MG TAB","قرص پرومتازین هیدروکلراید ۲۵ میلی‌گرم",{"code":222,"en":223,"fa":224},"50433","PROMETHAZINE HYDROCHLORIDE INJECTION PARENTERAL 25 mg\u002F1mL 2 mL","فرآورده تزریقی پرومتازین هیدروکلراید ۲۵ میلی‌گرم \u002F ۱ میلی‌لیتر ۲ میلی‌لیتر",[226],{"source":227,"section":228,"url":229},"darooyab-generic","G-822\u002FPromethazine","https:\u002F\u002Fwww.darooyab.ir\u002FG-822\u002FPromethazine",[231,235,239,242,245,248],{"kind":232,"url":233,"label":234},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=040596","ANDA040596",{"kind":236,"url":237,"label":238},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=6728bb41-5d50-4abb-bb73-993dcc16ee66","FDA Promethazine",{"kind":236,"url":240,"label":241},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4f99bbd5-02f7-2fed-e063-6394a90a6355","FDA Promethazine syrup",{"kind":243,"url":244,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682284.html",{"kind":246,"url":247,"label":197},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R06AD02",{"kind":249,"url":229,"label":8},"darooyab",{"pregnancy":251,"lactation":260,"pediatric":269,"geriatric":276},{"level":252,"text":253,"quote":256,"refs":257},"caution",{"fa":254,"en":255},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Diagnostic pregnancy tests based on immunological reactions between HCG and anti-HCG may result in false-negative or false-positive interpretations.",[258],{"source":34,"section":259},"Pregnancy Tests",{"level":261,"text":262,"quote":265,"refs":266},"avoid",{"fa":263,"en":264},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from promethazine hydrochloride tablets, USP a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[267],{"source":34,"section":268},"Nursing Mothers",{"level":261,"text":270,"quote":273,"refs":274},{"fa":271,"en":272},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","PROMETHAZINE HYDROCHLORIDE TABLETS, USP SHOULD NOT BE USED IN PEDIATRIC PATIENTS LESS THAN 2 YEARS OF AGE BECAUSE OF THE POTENTIAL FOR FATAL RESPIRATORY DEPRESSION.",[275],{"source":34,"section":153},{"level":252,"text":277,"quote":280,"refs":281},{"fa":278,"en":279},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal or cardiac function, and of concomitant disease or other drug therapy.",[282],{"source":34,"section":283},"Geriatric Use",{"kind":285,"refs":286,"id":234},"ANDA",[287],{"source":34,"section":288},"SPL approval \u002F marketing category",1792440742464]