[{"data":1,"prerenderedAt":252},["ShallowReactive",2],{"drug-propranolol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":35,"contraindications":102,"warnings":112,"renal":113,"monitoring":114,"interactions":115,"review":116,"examples":119,"atc":134,"iran":136,"links":192,"populations":212,"usApproval":247},"propranolol",1,{"fa":7,"en":8},"پروپرانولول","Propranolol","cardiovascular",{"fa":11,"en":12},"بتابلاکر غیرانتخابی","Non-selective beta-blocker",[14],{"name":15,"market":16},"Inderal","US",[18,19,7],"inderal","ایندرال",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"tab-20","tablet","oral","20 mg tablet (scored)",{"amount":27,"unit":28,"perUnit":23,"scored":29},20,"mg",true,[16],[32],{"source":33,"section":34},"fda-propranolol","How Supplied",[36,65,84],{"id":37,"disease":38,"label":39,"population":42,"type":46,"unit":28,"dose":47,"refs":55,"notes":58},"migraine","migraine-prophylaxis",{"fa":40,"en":41},"پیشگیری از میگرن — بزرگسال: ۸۰ mg\u002Fday منقسم","Migraine prophylaxis — adults: 80 mg\u002Fday divided",{"minAge":43},{"value":44,"unit":45},18,"year","titration",{"dividedDoses":48,"titration":49},2,{"start":50,"increment":51,"incrementEveryDays":52,"targetMin":53,"targetMax":54,"max":54},80,40,7,160,240,[56],{"source":33,"section":57},"Dosage and Administration",[59],{"text":60,"refs":63},{"fa":61,"en":62},"محدوده مؤثر ۱۶۰ تا ۲۴۰ mg\u002Fday؛ اگر ۴ تا ۶ هفته پس از حداکثر دوز پاسخ نبود، به‌تدریج قطع شود.","Effective 160–240 mg\u002Fday; if no response 4–6 weeks after the maximum dose, withdraw gradually.",[64],{"source":33,"section":57},{"id":66,"disease":67,"label":68,"population":71,"type":73,"unit":28,"dose":74,"refs":75,"notes":77},"htn","hypertension",{"fa":69,"en":70},"فشار خون — بزرگسال: ۴۰ mg دو بار در روز","Hypertension — adults: 40 mg twice daily",{"minAge":72},{"value":44,"unit":45},"fixed",{"perDose":51,"dosesPerDay":48},[76],{"source":33,"section":57},[78],{"text":79,"refs":82},{"fa":80,"en":81},"نگهدارنده معمول ۱۲۰ تا ۲۴۰ mg\u002Fday.","Usual maintenance 120–240 mg\u002Fday.",[83],{"source":33,"section":57},{"id":85,"disease":86,"label":87,"population":90,"type":73,"unit":28,"dose":92,"refs":93,"notes":95},"tremor","essential-tremor",{"fa":88,"en":89},"لرزش اساسی — بزرگسال: ۴۰ mg دو بار در روز","Essential tremor — adults: 40 mg twice daily",{"minAge":91},{"value":44,"unit":45},{"perDose":51,"dosesPerDay":48},[94],{"source":33,"section":57},[96],{"text":97,"refs":100},{"fa":98,"en":99},"معمولاً ۱۲۰ mg\u002Fday کافی است؛ گاهی ۲۴۰ تا ۳۲۰.","Usually 120 mg\u002Fday; occasionally 240–320.",[101],{"source":33,"section":57},[103],{"id":104,"severity":105,"text":106,"refs":109},"ci","block",{"fa":107,"en":108},"شوک کاردیوژنیک؛ برادی‌کاردی سینوسی و بلوک بیش از درجه یک؛ آسم برونشیال؛ حساسیت.","Cardiogenic shock; sinus bradycardia and greater than first-degree block; bronchial asthma; hypersensitivity.",[110],{"source":33,"section":111},"Contraindications",[],[],[],[],{"status":117,"reviewer":118,"date":118},"unverified",null,[120,125,129],{"regimen":37,"formulation":22,"input":121,"expect":124},{"ageYears":122,"weightKg":123},30,70,{"perDose":51,"tabletsPerDoseRounded":48},{"regimen":66,"formulation":22,"input":126,"expect":128},{"ageYears":127,"weightKg":50},50,{"tabletsPerDoseRounded":48},{"regimen":85,"formulation":22,"input":130,"expect":133},{"ageYears":131,"weightKg":132},60,75,{"perDose":51},[135],"C07AA05",{"status":137,"forms":138,"refs":187},"registered",[139,143,147,151,155,159,163,167,171,175,179,183],{"code":140,"en":141,"fa":142},"01067","PROPRANOLOL HCL 10MG TAB","قرص پروپرانولول هیدروکلراید ۱۰ میلی‌گرم",{"code":144,"en":145,"fa":146},"01949","PROPRANOLOL HCL 1MG\u002F1ML AMP","آمپول پروپرانولول هیدروکلراید ۱ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":148,"en":149,"fa":150},"07066","PROPRANOLOL HCL 20MG TAB","قرص پروپرانولول هیدروکلراید ۲۰ میلی‌گرم",{"code":152,"en":153,"fa":154},"06746","PROPRANOLOL HCL 40MG CAP","کپسول پروپرانولول هیدروکلراید ۴۰ میلی‌گرم",{"code":156,"en":157,"fa":158},"01068","PROPRANOLOL HCL 40MG TAB","قرص پروپرانولول هیدروکلراید ۴۰ میلی‌گرم",{"code":160,"en":161,"fa":162},"01070","PROPRANOLOL HCL 5MG\u002F5ML AMP","آمپول پروپرانولول هیدروکلراید ۵ میلی‌گرم \u002F ۵ میلی‌لیتر",{"code":164,"en":165,"fa":166},"07505","PROPRANOLOL HCL 80MG CAP","کپسول پروپرانولول هیدروکلراید ۸۰ میلی‌گرم",{"code":168,"en":169,"fa":170},"01069","PROPRANOLOL HCL 80MG TAB","قرص پروپرانولول هیدروکلراید ۸۰ میلی‌گرم",{"code":172,"en":173,"fa":174},"01654","PROPRANOLOL HCL SR 160MG TAB","قرص آهسته‌رهش پروپرانولول هیدروکلراید ۱۶۰ میلی‌گرم",{"code":176,"en":177,"fa":178},"02096","PROPRANOLOL HCL SR 80MG TAB","قرص آهسته‌رهش پروپرانولول هیدروکلراید ۸۰ میلی‌گرم",{"code":180,"en":181,"fa":182},"52837","PROPRANOLOL HYDROCHLORIDE SYRUP ORAL 4.28 mg\u002F1mL 120 mL","شربت پروپرانولول هیدروکلراید ۴٫۲۸ میلی‌گرم \u002F ۱ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":184,"en":185,"fa":186},"53087","PROPRANOLOL HYDROCHLORIDE SYRUP ORAL 4.28 mg\u002F1mL 60 mL","شربت پروپرانولول هیدروکلراید ۴٫۲۸ میلی‌گرم \u002F ۱ میلی‌لیتر ۶۰ میلی‌لیتر",[188],{"source":189,"section":190,"url":191},"darooyab-generic","G-1859\u002FPropranolol","https:\u002F\u002Fwww.darooyab.ir\u002FG-1859\u002FPropranolol",[193,197,201,204,207,210],{"kind":194,"url":195,"label":196},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=070322","ANDA070322",{"kind":198,"url":199,"label":200},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=582fe781-0759-4622-8fa6-b7d90e94e696","FDA Propranolol",{"kind":202,"url":203,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682607.html",{"kind":202,"url":205,"label":206},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa615024.html","Propranolol (Infantile Hemangioma)",{"kind":208,"url":209,"label":135},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C07AA05",{"kind":211,"url":191,"label":8},"darooyab",{"pregnancy":213,"lactation":222,"pediatric":230,"geriatric":239},{"level":214,"text":215,"quote":218,"refs":219},"caution",{"fa":216,"en":217},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category C In a series of reproductive and developmental toxicology studies, propranolol hydrochloride was given to rats by gavage or in the diet throughout pregnancy and lactation.",[220],{"source":33,"section":221},"Pregnancy",{"level":214,"text":223,"quote":226,"refs":227},{"fa":224,"en":225},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when propranolol hydrochloride is administered to a nursing woman.",[228],{"source":33,"section":229},"Nursing Mothers",{"level":231,"text":232,"quote":235,"refs":236},"not-established",{"fa":233,"en":234},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness of propranolol in pediatric patients have not been established.",[237],{"source":33,"section":238},"Pediatric Use",{"level":214,"text":240,"quote":243,"refs":244},{"fa":241,"en":242},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy.",[245],{"source":33,"section":246},"Geriatric Use",{"kind":248,"refs":249,"id":196},"ANDA",[250],{"source":33,"section":251},"SPL approval \u002F marketing category",1792191868718]