[{"data":1,"prerenderedAt":272},["ShallowReactive",2],{"drug-ramipril":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":24,"regimens":63,"contraindications":144,"warnings":163,"renal":164,"monitoring":165,"interactions":166,"review":167,"examples":170,"atc":185,"iran":187,"links":215,"populations":232,"usApproval":267},"ramipril",1,{"fa":7,"en":8},"رامی‌پریل","Ramipril","cardiovascular",{"fa":11,"en":12},"مهارکننده ACE","ACE inhibitor",[14],{"name":15,"market":16},"Altace","US",[18,19,20,21,22,23],"altace","رامیپریل","رامی پریل","تریتاس","tritace","ACEI",[25,39,47,55],{"id":26,"form":27,"route":28,"label":29,"concentration":30,"markets":34,"refs":35},"cap-1-25","capsule","oral","1.25 mg capsule",{"amount":31,"unit":32,"perUnit":27,"scored":33},1.25,"mg",false,[16],[36],{"source":37,"section":38},"fda-ramipril","3",{"id":40,"form":27,"route":28,"label":41,"concentration":42,"markets":44,"refs":45},"cap-2-5","2.5 mg capsule",{"amount":43,"unit":32,"perUnit":27,"scored":33},2.5,[16],[46],{"source":37,"section":38},{"id":48,"form":27,"route":28,"label":49,"concentration":50,"markets":52,"refs":53},"cap-5","5 mg capsule",{"amount":51,"unit":32,"perUnit":27,"scored":33},5,[16],[54],{"source":37,"section":38},{"id":56,"form":27,"route":28,"label":57,"concentration":58,"markets":60,"refs":61},"cap-10","10 mg capsule",{"amount":59,"unit":32,"perUnit":27,"scored":33},10,[16],[62],{"source":37,"section":38},[64,90,109,130],{"id":65,"disease":66,"label":67,"population":70,"type":74,"unit":32,"dose":75,"refs":76,"limits":79,"notes":83},"htn","hypertension",{"fa":68,"en":69},"فشار خون — شروع ۲٫۵ mg یک بار در روز","Hypertension — start 2.5 mg once daily",{"minAge":71},{"value":72,"unit":73},18,"year","fixed",{"perDose":43,"dosesPerDay":5},[77],{"source":37,"section":78},"2.1",{"maxPerDay":80,"refs":81},20,[82],{"source":37,"section":78},[84],{"text":85,"refs":88},{"fa":86,"en":87},"نگهدارنده ۲٫۵ تا ۲۰ mg\u002Fday یک‌جا یا دو نوبت.","Maintenance 2.5–20 mg\u002Fday once or in two doses.",[89],{"source":37,"section":78},{"id":91,"disease":92,"label":93,"population":96,"type":74,"unit":32,"dose":98,"refs":99,"notes":102},"cv-risk","atherothrombotic-prevention",{"fa":94,"en":95},"کاهش خطر MI، سکته و مرگ قلبی — ۲٫۵ mg هفته اول، سپس ۵ mg، هدف ۱۰ mg","Reduce MI\u002Fstroke\u002FCV death — 2.5 mg week 1, then 5 mg, target 10 mg",{"minAge":97},{"value":72,"unit":73},{"perDose":43,"dosesPerDay":5},[100],{"source":37,"section":101},"2.2",[103],{"text":104,"refs":107},{"fa":105,"en":106},"۲٫۵ mg یک هفته، ۵ mg سه هفته، سپس در صورت تحمل ۱۰ mg یک بار در روز.","2.5 mg for 1 week, 5 mg for 3 weeks, then as tolerated 10 mg once daily.",[108],{"source":37,"section":101},{"id":110,"disease":111,"label":112,"population":115,"type":74,"unit":32,"dose":117,"refs":119,"notes":122},"hf-mi","heart-failure",{"fa":113,"en":114},"نارسایی قلبی پس از MI — ۲٫۵ mg دو بار در روز","Heart failure after MI — 2.5 mg twice daily",{"minAge":116},{"value":72,"unit":73},{"perDose":43,"dosesPerDay":118},2,[120],{"source":37,"section":121},"2.3",[123],{"text":124,"refs":127},{"fa":125,"en":126},"افت فشار: ۱٫۲۵ mg دو بار. هدف ۵ mg دو بار با فاصله حدود ۳ هفته.","If hypotensive: 1.25 mg twice daily. Target 5 mg twice daily, steps about 3 weeks apart.",[128],{"source":37,"section":129},"2",{"id":131,"disease":66,"label":132,"population":135,"type":137,"unit":32,"dose":138,"refs":142},"peds",{"fa":133,"en":134},"زیر ۱۸ سال","Under 18 years",{"maxAge":136},{"value":72,"unit":73},"notCalculated",{"reason":139},{"fa":140,"en":141},"بی‌خطری و اثربخشی در کودکان ثابت نشده است.","Safety and effectiveness in children not established.",[143],{"source":37,"section":78},[145,154],{"id":146,"severity":147,"text":148,"refs":151},"ci","block",{"fa":149,"en":150},"حساسیت یا آنژیوادم با هر ACEI؛ همراه ساکوبیتریل؛ آلیسکیرن در دیابت.","Hypersensitivity or angioedema with any ACE inhibitor; with sacubitril; aliskiren in diabetes.",[152],{"source":37,"section":153},"4",{"id":155,"severity":156,"text":157,"refs":160},"pregnancy","warn",{"fa":158,"en":159},"هشدار جعبه‌ای: سمیت جنینی — با تشخیص بارداری فوراً قطع شود.","Boxed warning: fetal toxicity — stop as soon as pregnancy is detected.",[161],{"source":37,"section":162},"Boxed Warning",[],[],[],[],{"status":168,"reviewer":169,"date":169},"unverified",null,[171,176,180],{"regimen":65,"formulation":40,"input":172,"expect":175},{"ageYears":173,"weightKg":174},50,80,{"perDose":43},{"regimen":91,"formulation":40,"input":177,"expect":179},{"ageYears":178,"weightKg":174},60,{"perDose":43},{"regimen":110,"formulation":40,"input":181,"expect":184},{"ageYears":182,"weightKg":183},65,70,{"perDay":51},[186],"C09AA05",{"status":188,"forms":189,"refs":210},"registered",[190,194,198,202,206],{"code":191,"en":192,"fa":193},"08849","RAMIPRIL 1.25MG TAB","قرص رامیپریل ۱٫۲۵ میلی‌گرم",{"code":195,"en":196,"fa":197},"06487","RAMIPRIL 10MG TAB","قرص رامیپریل ۱۰ میلی‌گرم",{"code":199,"en":200,"fa":201},"08046","RAMIPRIL 2.5MG CAP","کپسول رامیپریل ۲٫۵ میلی‌گرم",{"code":203,"en":204,"fa":205},"07701","RAMIPRIL 2.5MG TAB","قرص رامیپریل ۲٫۵ میلی‌گرم",{"code":207,"en":208,"fa":209},"07705","RAMIPRIL 5MG TAB","قرص رامیپریل ۵ میلی‌گرم",[211],{"source":212,"section":213,"url":214},"darooyab-generic","G-1865\u002FRamipril","https:\u002F\u002Fwww.darooyab.ir\u002FG-1865\u002FRamipril",[216,220,224,227,230],{"kind":217,"url":218,"label":219},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=091604","ANDA091604",{"kind":221,"url":222,"label":223},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=d6d57158-e8f9-4c91-8317-0374e0c87d33","FDA Ramipril",{"kind":225,"url":226,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa692027.html",{"kind":228,"url":229,"label":186},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C09AA05",{"kind":231,"url":214,"label":8},"darooyab",{"pregnancy":233,"lactation":241,"pediatric":250,"geriatric":259},{"level":234,"text":235,"quote":238,"refs":239},"avoid",{"fa":236,"en":237},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","WARNING: FETAL TOXICITY See full prescribing information for complete boxed warning.",[240],{"source":37,"section":162},{"level":242,"text":243,"quote":246,"refs":247},"caution",{"fa":244,"en":245},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Ingestion of a single 10 mg oral dose of ramipril resulted in undetectable amounts of ramipril and its metabolites in breast milk.",[248],{"source":37,"section":249},"8.3",{"level":251,"text":252,"quote":255,"refs":256},"not-established",{"fa":253,"en":254},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Safety and effectiveness in pediatric patients have not been established.",[257],{"source":37,"section":258},"8.4",{"level":242,"text":260,"quote":263,"refs":264},{"fa":261,"en":262},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the total number of patients who received ramipril in U.S. clinical studies of ramipril, 11% were ≥65 years of age while 0.2% were ≥75 years of age.",[265],{"source":37,"section":266},"8.5",{"kind":268,"refs":269,"id":219},"ANDA",[270],{"source":37,"section":271},"SPL approval \u002F marketing category",1792191868889]