[{"data":1,"prerenderedAt":233},["ShallowReactive",2],{"drug-rivaroxaban":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":60,"contraindications":106,"warnings":125,"renal":126,"monitoring":127,"interactions":128,"review":129,"examples":132,"atc":143,"iran":145,"links":169,"populations":186,"usApproval":228},"rivaroxaban",1,{"fa":7,"en":8},"ریواروکسابان","Rivaroxaban","blood",{"fa":11,"en":12},"ضدانعقاد خوراکی (مهارکننده فاکتور Xa)","Oral anticoagulant (factor Xa inhibitor)",[14],{"name":15,"market":16},"Xarelto","US",[18,19,7,20],"xarelto","زارلتو","DOAC",[22,36,44,52],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-2-5","tablet","oral","2.5 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},2.5,"mg",false,[16],[33],{"source":34,"section":35},"fda-xarelto","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-10","10 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},10,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-15","15 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},15,[16],[51],{"source":34,"section":35},{"id":53,"form":24,"route":25,"label":54,"concentration":55,"markets":57,"refs":58},"tab-20","20 mg tablet",{"amount":56,"unit":29,"perUnit":24,"scored":30},20,[16],[59],{"source":34,"section":35},[61,85],{"id":62,"disease":63,"label":64,"population":67,"type":71,"unit":29,"dose":72,"refs":73,"notes":76},"af","atrial-fibrillation",{"fa":65,"en":66},"AF غیردریچه‌ای — ۲۰ mg یک بار با شام","Non-valvular AF — 20 mg once daily with the evening meal",{"minAge":68},{"value":69,"unit":70},18,"year","fixed",{"perDose":56,"dosesPerDay":5},[74],{"source":34,"section":75},"2.1",[77],{"text":78,"refs":81},{"fa":79,"en":80},"بر اساس کلیرانس کراتینین ۱۵ یا ۲۰ mg. قرص‌های ۱۵ و ۲۰ mg با غذا.","15 or 20 mg depending on creatinine clearance. 15 and 20 mg tablets with food.",[82,84],{"source":34,"section":83},"2",{"source":34,"section":75},{"id":86,"disease":87,"label":88,"population":91,"type":71,"unit":29,"dose":93,"refs":95,"durationDays":97,"notes":99},"vte","venous-thromboembolism",{"fa":89,"en":90},"درمان DVT\u002FPE — ۱۵ mg دو بار با غذا ۲۱ روز، سپس ۲۰ mg یک بار","DVT\u002FPE — 15 mg twice daily with food for 21 days, then 20 mg once daily",{"minAge":92},{"value":69,"unit":70},{"perDose":48,"dosesPerDay":94},2,[96],{"source":34,"section":83},{"min":98,"max":98},21,[100],{"text":101,"refs":104},{"fa":102,"en":103},"پس از ۲۱ روز ۲۰ mg یک بار با غذا. پیشگیری از عود پس از ۶ ماه: ۱۰ mg یک بار.","After 21 days 20 mg once daily with food. Recurrence prevention after 6 months: 10 mg once daily.",[105],{"source":34,"section":83},[107,116],{"id":108,"severity":109,"text":110,"refs":113},"ci","block",{"fa":111,"en":112},"خونریزی پاتولوژیک فعال؛ حساسیت شدید.","Active pathological bleeding; severe hypersensitivity.",[114],{"source":34,"section":115},"4",{"id":117,"severity":118,"text":119,"refs":122},"boxed","warn",{"fa":120,"en":121},"هشدار جعبه‌ای: قطع زودهنگام خطر ترومبوز را بالا می‌برد؛ هماتوم نخاعی با بی‌حسی نخاعی.","Boxed warning: premature discontinuation raises thrombotic risk; spinal\u002Fepidural haematoma with neuraxial anaesthesia.",[123],{"source":34,"section":124},"Boxed Warning",[],[],[],[],{"status":130,"reviewer":131,"date":131},"unverified",null,[133,138],{"regimen":62,"formulation":53,"input":134,"expect":137},{"ageYears":135,"weightKg":136},70,80,{"perDose":56},{"regimen":86,"formulation":45,"input":139,"expect":141},{"ageYears":140,"weightKg":136},50,{"perDay":142},30,[144],"B01AF01",{"status":146,"forms":147,"refs":164},"registered",[148,152,156,160],{"code":149,"en":150,"fa":151},"17597","RIVAROXABAN 10MG TAB","قرص ریواروکسابان ۱۰ میلی‌گرم",{"code":153,"en":154,"fa":155},"22856","RIVAROXABAN 20MG TAB","قرص ریواروکسابان ۲۰ میلی‌گرم",{"code":157,"en":158,"fa":159},"50005","RIVAROXABAN 15MG TAB","قرص ریواروکسابان ۱۵ میلی‌گرم",{"code":161,"en":162,"fa":163},"52235","RIVAROXABAN 2.5MG TAB","قرص ریواروکسابان ۲٫۵ میلی‌گرم",[165],{"source":166,"section":167,"url":168},"darooyab-generic","G-4798\u002FRivaroxaban","https:\u002F\u002Fwww.darooyab.ir\u002FG-4798\u002FRivaroxaban",[170,174,178,181,184],{"kind":171,"url":172,"label":173},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=022406","NDA022406",{"kind":175,"url":176,"label":177},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=10db92f9-2300-4a80-836b-673e1ae91610","FDA Xarelto",{"kind":179,"url":180,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa611049.html",{"kind":182,"url":183,"label":144},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=B01AF01",{"kind":185,"url":168,"label":8},"darooyab",{"pregnancy":187,"lactation":196,"pediatric":204,"geriatric":212,"reproductive":220},{"level":188,"text":189,"quote":192,"refs":193},"caution",{"fa":190,"en":191},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary The limited available data on XARELTO in pregnant women are insufficient to inform a drug-associated risk of adverse developmental outcomes.",[194],{"source":34,"section":195},"8.1",{"level":188,"text":197,"quote":200,"refs":201},{"fa":198,"en":199},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Rivaroxaban has been detected in human milk.",[202],{"source":34,"section":203},"8.2",{"level":188,"text":205,"quote":208,"refs":209},{"fa":206,"en":207},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of XARELTO have been established in pediatric patients from birth to less than 18 years for the treatment of VTE and the reduction in risk of recurrent VTE.",[210],{"source":34,"section":211},"8.4",{"level":188,"text":213,"quote":216,"refs":217},{"fa":214,"en":215},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the total number of adult patients in clinical trials for the approved indications of XARELTO (N=64,943 patients), 64 percent were 65 years and over, with 27 percent 75 years and over.",[218],{"source":34,"section":219},"8.5",{"level":188,"text":221,"quote":224,"refs":225},{"fa":222,"en":223},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Females of reproductive potential requiring anticoagulation should discuss pregnancy planning with their physician.",[226],{"source":34,"section":227},"8.3",{"kind":229,"refs":230,"id":173},"NDA",[231],{"source":34,"section":232},"SPL approval \u002F marketing category",1792191866180]