[{"data":1,"prerenderedAt":190},["ShallowReactive",2],{"drug-tiotropium":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":45,"contraindications":82,"warnings":92,"renal":93,"monitoring":94,"interactions":95,"review":96,"examples":99,"atc":111,"iran":113,"links":133,"populations":151,"usApproval":185},"tiotropium",1,{"fa":7,"en":8},"تیوتروپیوم (اسپیریوا)","Tiotropium","respiratory",{"fa":11,"en":12},"آنتی‌کولینرژیک طولانی‌اثر (LAMA)","Long-acting anticholinergic (LAMA)",[14],{"name":15,"market":16},"Spiriva Respimat","US",[18,19,20,21],"spiriva","اسپیریوا","تیوتروپیوم","LAMA",[23,37],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"respimat-1-25","inhaler","inhaled","1.25 mcg per actuation (Respimat)",{"amount":29,"unit":30,"perUnit":31},1.25,"mcg","actuation",[16],[34],{"source":35,"section":36},"fda-spiriva","3",{"id":38,"form":25,"route":26,"label":39,"concentration":40,"markets":42,"refs":43},"respimat-2-5","2.5 mcg per actuation (Respimat)",{"amount":41,"unit":30,"perUnit":31},2.5,[16],[44],{"source":35,"section":36},[46,62],{"id":47,"disease":47,"label":48,"population":51,"type":55,"unit":30,"dose":56,"refs":58,"allowedFormulations":61},"copd",{"fa":49,"en":50},"COPD — ۲ پاف ۲٫۵ mcg یک بار در روز","COPD — 2 puffs of 2.5 mcg once daily",{"minAge":52},{"value":53,"unit":54},18,"year","fixed",{"perDose":57,"dosesPerDay":5},5,[59],{"source":35,"section":60},"2.1",[38],{"id":63,"disease":63,"label":64,"population":67,"type":55,"unit":30,"dose":70,"refs":71,"allowedFormulations":74,"notes":75},"asthma",{"fa":65,"en":66},"آسم — ۶ سال به بالا: ۲ پاف ۱٫۲۵ mcg یک بار در روز","Asthma — ≥6 y: 2 puffs of 1.25 mcg once daily",{"minAge":68},{"value":69,"unit":54},6,{"perDose":41,"dosesPerDay":5},[72],{"source":35,"section":73},"2.2",[24],[76],{"text":77,"refs":80},{"fa":78,"en":79},"حداکثر اثر ممکن است ۴ تا ۸ هفته طول بکشد.","Maximum benefit may take 4–8 weeks.",[81],{"source":35,"section":73},[83],{"id":84,"severity":85,"text":86,"refs":89},"ci","block",{"fa":87,"en":88},"حساسیت به تیوتروپیوم، ایپراتروپیوم یا اجزا.","Hypersensitivity to tiotropium, ipratropium or any component.",[90],{"source":35,"section":91},"4",[],[],[],[],{"status":97,"reviewer":98,"date":98},"unverified",null,[100,106],{"regimen":47,"formulation":38,"input":101,"expect":104},{"ageYears":102,"weightKg":103},65,70,{"perDose":57,"tabletsPerDoseRounded":105},2,{"regimen":63,"formulation":24,"input":107,"expect":110},{"ageYears":108,"weightKg":109},10,30,{"perDose":41,"tabletsPerDoseRounded":105},[112],"R03BB04",{"status":114,"forms":115,"refs":128},"registered",[116,120,124],{"code":117,"en":118,"fa":119},"06054","TIOTROPIUM 18MCG TAB","قرص تیوتروپیوم ۱۸ میکروگرم",{"code":121,"en":122,"fa":123},"04189","TIOTROPIUM   0.018MG FOR INHAL","تیوتروپیوم ۰٫۰۱۸ میلی‌گرم استنشاقی",{"code":125,"en":126,"fa":127},"52358","TIOTROPIUM (AS BROMIDE) SOLUTION RESPIRATORY 2.5 ug\u002F1{Puff} 30 {dose}","فرآورده استنشاقی تیوتروپیوم (معادل بروماید) ۲٫۵ میکروگرم \u002F ۱ { } ۳۰ { دوز }",[129],{"source":130,"section":131,"url":132},"darooyab-generic","G-1497\u002FTiotropium","https:\u002F\u002Fwww.darooyab.ir\u002FG-1497\u002FTiotropium",[134,138,142,146,149],{"kind":135,"url":136,"label":137},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=207070","NDA207070",{"kind":139,"url":140,"label":141},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=7b656b14-fcaa-2741-f6f0-e0be48971c02","FDA Spiriva Respimat",{"kind":143,"url":144,"label":145},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa604018.html","Tiotropium Oral Inhalation",{"kind":147,"url":148,"label":112},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=R03BB04",{"kind":150,"url":132,"label":8},"darooyab",{"pregnancy":152,"lactation":161,"pediatric":169,"geriatric":177},{"level":153,"text":154,"quote":157,"refs":158},"caution",{"fa":155,"en":156},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary The limited human data with SPIRIVA RESPIMAT use during pregnancy are insufficient to inform a drug-associated risk of adverse pregnancy-related outcomes.",[159],{"source":35,"section":160},"8.1",{"level":153,"text":162,"quote":165,"refs":166},{"fa":163,"en":164},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of tiotropium in human milk, the effects on the breastfed infant, or the effects on milk production.",[167],{"source":35,"section":168},"8.2",{"level":153,"text":170,"quote":173,"refs":174},{"fa":171,"en":172},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and efficacy of SPIRIVA RESPIMAT 2.5 mcg have been established in pediatric patients aged 6 to 17 years with asthma in 6 clinical trials up to 1 year in duration.",[175],{"source":35,"section":176},"8.4",{"level":153,"text":178,"quote":181,"refs":182},{"fa":179,"en":180},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Based on available data, no adjustment of SPIRIVA RESPIMAT dosage in geriatric patients is warranted [see Clinical Pharmacology (12.3) ].",[183],{"source":35,"section":184},"8.5",{"kind":186,"refs":187,"id":137},"NDA",[188],{"source":35,"section":189},"SPL approval \u002F marketing category",1792191881078]