[{"data":1,"prerenderedAt":265},["ShallowReactive",2],{"drug-tramadol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":61,"contraindications":92,"warnings":121,"renal":122,"monitoring":123,"interactions":124,"review":125,"examples":128,"atc":140,"iran":142,"links":201,"populations":218,"usApproval":260},"tramadol",1,{"fa":7,"en":8},"ترامادول","Tramadol","nervous-system",{"fa":11,"en":12},"ضددرد اپیوئیدی","Opioid analgesic",[14],{"name":15,"market":16},"Ultram","US",[18,7,19,20],"ultram","ترامال","tramal",[22,36,45,53],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-25","tablet","oral","25 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},25,"mg",false,[16],[33],{"source":34,"section":35},"fda-tramadol","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":42,"refs":43},"tab-50","50 mg tablet (scored)",{"amount":40,"unit":29,"perUnit":24,"scored":41},50,true,[16],[44],{"source":34,"section":35},{"id":46,"form":24,"route":25,"label":47,"concentration":48,"markets":50,"refs":51},"tab-75","75 mg tablet (scored)",{"amount":49,"unit":29,"perUnit":24,"scored":41},75,[16],[52],{"source":34,"section":35},{"id":54,"form":24,"route":25,"label":55,"concentration":56,"markets":58,"refs":59},"tab-100","100 mg tablet (scored)",{"amount":57,"unit":29,"perUnit":24,"scored":41},100,[16],[60],{"source":34,"section":35},[62],{"id":63,"disease":64,"label":65,"population":68,"type":72,"unit":29,"dose":73,"refs":76,"limits":79,"notes":83},"maint","pain",{"fa":66,"en":67},"درد متوسط تا شدید — پس از تیتراسیون: ۵۰ تا ۱۰۰ mg هر ۴ تا ۶ ساعت","Moderate–severe pain — after titration: 50–100 mg every 4–6 h",{"minAge":69},{"value":70,"unit":71},18,"year","fixed",{"perDose":40,"perDoseMax":57,"dosesPerDay":74,"intervalHours":75},4,6,[77],{"source":34,"section":78},"2",{"maxPerDay":80,"refs":81},400,[82],{"source":34,"section":78},[84],{"text":85,"refs":88},{"fa":86,"en":87},"شروع ۲۵ mg\u002Fday و افزایش ۲۵ mg هر ۳ روز تا ۱۰۰ mg\u002Fday (۲۵ چهار بار)، سپس ۵۰ mg هر ۳ روز تا ۲۰۰ mg\u002Fday. بالای ۷۵ سال حداکثر ۳۰۰ mg\u002Fday. نارسایی شدید کلیه: فاصله دوز ۱۲ ساعت.","Start 25 mg\u002Fday, increase by 25 mg every 3 days to 100 mg\u002Fday (25 four times daily), then by 50 mg every 3 days to 200 mg\u002Fday. Over 75 y max 300 mg\u002Fday. Severe renal impairment: 12-hour interval.",[89,90],{"source":34,"section":78},{"source":34,"section":91},"2.3",[93,105,112],{"id":94,"severity":95,"rule":96,"text":99,"refs":102},"under-12","block",{"maxAge":97},{"value":98,"unit":71},12,{"fa":100,"en":101},"زیر ۱۲ سال منع مصرف دارد (دپرسیون تنفسی کشنده).","Contraindicated under 12 years (fatal respiratory depression).",[103],{"source":34,"section":104},"4",{"id":106,"severity":95,"text":107,"refs":110},"ci",{"fa":108,"en":109},"پس از تونسیلکتومی\u002Fآدنوئیدکتومی زیر ۱۸ سال؛ دپرسیون تنفسی؛ آسم حاد یا شدید بدون پایش؛ انسداد گوارشی؛ حساسیت به اپیوئید؛ MAOI در ۱۴ روز اخیر.","After tonsillectomy\u002Fadenoidectomy under 18; respiratory depression; acute or severe asthma unmonitored; GI obstruction; opioid hypersensitivity; MAOI within 14 days.",[111],{"source":34,"section":104},{"id":113,"severity":114,"text":115,"refs":118},"boxed","warn",{"fa":116,"en":117},"هشدار جعبه‌ای: اعتیاد و سوءمصرف، دپرسیون تنفسی، مصرف تصادفی کشنده در کودکان، تداخل با بنزودیازپین‌ها.","Boxed warning: addiction and misuse, respiratory depression, fatal accidental ingestion by children, interaction with benzodiazepines.",[119],{"source":34,"section":120},"Boxed Warning",[],[],[],[],{"status":126,"reviewer":127,"date":127},"unverified",null,[129,134],{"regimen":63,"formulation":37,"input":130,"expect":133},{"ageYears":131,"weightKg":132},40,70,{"perDose":40,"upperPerDose":57},{"regimen":63,"formulation":37,"input":135,"expect":138},{"ageYears":136,"weightKg":137},10,35,{"status":139},"blocked",[141],"N02AX02",{"status":143,"forms":144,"refs":196},"registered",[145,149,153,157,161,165,169,173,177,181,185,188,192],{"code":146,"en":147,"fa":148},"11402","TRAMADOL 100MG SUSP","سوسپانسیون ترامادول ۱۰۰ میلی‌گرم",{"code":150,"en":151,"fa":152},"08921","TRAMADOL 10ML DROP","قطره ترامادول ۱۰ میلی‌لیتر",{"code":154,"en":155,"fa":156},"02103","TRAMADOL HCL 100MG TAB","قرص ترامادول هیدروکلراید ۱۰۰ میلی‌گرم",{"code":158,"en":159,"fa":160},"02013","TRAMADOL HCL 100MG\u002F2ML AMP","آمپول ترامادول هیدروکلراید ۱۰۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":162,"en":163,"fa":164},"06491","TRAMADOL HCL 20MG CAP","کپسول ترامادول هیدروکلراید ۲۰ میلی‌گرم",{"code":166,"en":167,"fa":168},"01982","TRAMADOL HCL 50MG CAP","کپسول ترامادول هیدروکلراید ۵۰ میلی‌گرم",{"code":170,"en":171,"fa":172},"02102","TRAMADOL HCL 50MG TAB","قرص ترامادول هیدروکلراید ۵۰ میلی‌گرم",{"code":174,"en":175,"fa":176},"02708","TRAMADOL HCL 50MG\u002F1ML AMP","آمپول ترامادول هیدروکلراید ۵۰ میلی‌گرم \u002F ۱ میلی‌لیتر",{"code":178,"en":179,"fa":180},"02190","TRAMADOL HCL SR 100MG TAB","قرص آهسته‌رهش ترامادول هیدروکلراید ۱۰۰ میلی‌گرم",{"code":182,"en":183,"fa":184},"11401","TRAMADOL HYDROCHLORIDE SR 200MG TAB","قرص آهسته‌رهش ترامادول هیدروکلراید ۲۰۰ میلی‌گرم",{"code":186,"en":187,"fa":184},"52843","TRAMADOL HYDROCHLORIDE TABLET, EXTENDED RELEASE ORAL 200 mg",{"code":189,"en":190,"fa":191},"52898","TRAMADOL HYDROCHLORIDE TABLET, EXTENDED RELEASE ORAL 300 mg","قرص آهسته‌رهش ترامادول هیدروکلراید ۳۰۰ میلی‌گرم",{"code":193,"en":194,"fa":195},"53076","TRAMADOL HYDROCHLORIDE INJECTION PARENTERAL 50 mg\u002F1mL 2 mL","فرآورده تزریقی ترامادول هیدروکلراید ۵۰ میلی‌گرم \u002F ۱ میلی‌لیتر ۲ میلی‌لیتر",[197],{"source":198,"section":199,"url":200},"darooyab-generic","G-205\u002FTramadol","https:\u002F\u002Fwww.darooyab.ir\u002FG-205\u002FTramadol",[202,206,210,213,216],{"kind":203,"url":204,"label":205},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=208708","ANDA208708",{"kind":207,"url":208,"label":209},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=84b12129-cf10-4a3e-889c-990ebabdece6","FDA Tramadol",{"kind":211,"url":212,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695011.html",{"kind":214,"url":215,"label":141},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N02AX02",{"kind":217,"url":200,"label":8},"darooyab",{"pregnancy":219,"lactation":227,"pediatric":235,"geriatric":243,"reproductive":252},{"level":220,"text":221,"quote":224,"refs":225},"avoid",{"fa":222,"en":223},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Neonatal Opioid Withdrawal Syndrome (NOWS) Advise pregnant women using opioids for an extended period of time of the risk of Neonatal Opioid Withdrawal Syndrome, which may be life-threatening if not recognized and treated.",[226],{"source":34,"section":120},{"level":220,"text":228,"quote":231,"refs":232},{"fa":229,"en":230},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions, including excess sedation and respiratory depression in a breastfed infant, advise patients that breastfeeding is not recommended during treatment with tramadol hydrochloride tablets [see Warnings and Precautions (5.4) ] .",[233],{"source":34,"section":234},"8.2",{"level":236,"text":237,"quote":240,"refs":241},"contraindicated",{"fa":238,"en":239},"برچسب: در کودکان زیر سن مشخص منع مصرف دارد.","Label: contraindicated in children below a stated age.","Tramadol Hydrochloride Tablets, USP are contraindicated for: • all children younger than 12 years of age [see Warnings and Precautions (5.4) ]. • post-operative management in children younger than 18 years of age following tonsillectomy and\u002For adenoidectomy [see Warnings and Precautions (5.4) ].",[242],{"source":34,"section":104},{"level":244,"text":245,"quote":248,"refs":249},"caution",{"fa":246,"en":247},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to to regularly evaluate renal function.",[250],{"source":34,"section":251},"8.5",{"level":244,"text":253,"quote":256,"refs":257},{"fa":254,"en":255},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Use of opioids for an extended period of time may cause reduced fertility in females and males of reproductive potential.",[258],{"source":34,"section":259},"8.3",{"kind":261,"refs":262,"id":205},"ANDA",[263],{"source":34,"section":264},"SPL approval \u002F marketing category",1792191876573]