[{"data":1,"prerenderedAt":185},["ShallowReactive",2],{"drug-ursodiol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":24,"regimens":39,"contraindications":69,"warnings":70,"renal":71,"monitoring":72,"interactions":73,"review":74,"examples":77,"atc":88,"iran":90,"links":126,"populations":145,"usApproval":180},"ursodiol",1,{"fa":7,"en":8},"اورسودیول (اورسوداکسی‌کولیک اسید)","Ursodiol (ursodeoxycholic acid)","alimentary-metabolism",{"fa":11,"en":12},"اسید صفراوی","Bile acid",[14],{"name":15,"market":16},"Actigall","US",[18,19,20,21,22,23],"actigall","urso","اورسوبیل","اورسودیول","اورسو","UDCA",[25],{"id":26,"form":27,"route":28,"label":29,"concentration":30,"markets":34,"refs":35},"cap-300","capsule","oral","300 mg capsule",{"amount":31,"unit":32,"perUnit":27,"scored":33},300,"mg",false,[16],[36],{"source":37,"section":38},"fda-ursodiol","How Supplied",[40,58],{"id":41,"disease":42,"label":43,"population":46,"type":50,"unit":32,"dose":51,"refs":55},"dissolve","gallstones",{"fa":44,"en":45},"حل سنگ صفرای رادیولوسنت — ۸ تا ۱۰ mg\u002Fkg\u002Fday در ۲ یا ۳ نوبت","Radiolucent gallstone dissolution — 8–10 mg\u002Fkg\u002Fday in 2–3 doses",{"minAge":47},{"value":48,"unit":49},18,"year","weightBased",{"perKgPerDay":52,"perKgPerDayMax":53,"dividedDoses":54},8,10,2,[56],{"source":37,"section":57},"Dosage and Administration",{"id":59,"disease":42,"label":60,"population":63,"type":65,"unit":32,"dose":66,"refs":67},"prevent",{"fa":61,"en":62},"پیشگیری از سنگ صفرا در کاهش وزن سریع — ۳۰۰ mg دو بار","Gallstone prevention in rapid weight loss — 300 mg twice daily",{"minAge":64},{"value":48,"unit":49},"fixed",{"perDose":31,"dosesPerDay":54},[68],{"source":37,"section":57},[],[],[],[],[],{"status":75,"reviewer":76,"date":76},"unverified",null,[78,83],{"regimen":41,"formulation":26,"input":79,"expect":82},{"ageYears":80,"weightKg":81},50,75,{"perDose":31},{"regimen":59,"formulation":26,"input":84,"expect":87},{"ageYears":85,"weightKg":86},40,110,{"perDose":31},[89],"A05AA02",{"status":91,"forms":92,"refs":121},"registered",[93,97,101,105,109,113,117],{"code":94,"en":95,"fa":96},"09895","URSODEOXYCHOLIC ACID 150MG TAB","قرص اورسودئوکسی‌کولیک اسید ۱۵۰ میلی‌گرم",{"code":98,"en":99,"fa":100},"01736","URSODEOXYCHOLIC ACID 250MG CAP","کپسول اورسودئوکسی‌کولیک اسید ۲۵۰ میلی‌گرم",{"code":102,"en":103,"fa":104},"01273","URSODEOXYCHOLIC ACID 250MG TAB","قرص اورسودئوکسی‌کولیک اسید ۲۵۰ میلی‌گرم",{"code":106,"en":107,"fa":108},"02497","URSODEOXYCHOLIC ACID 300MG CAP","کپسول اورسودئوکسی‌کولیک اسید ۳۰۰ میلی‌گرم",{"code":110,"en":111,"fa":112},"12036","URSODEOXYCHOLIC ACID 300MG TAB","قرص اورسودئوکسی‌کولیک اسید ۳۰۰ میلی‌گرم",{"code":114,"en":115,"fa":116},"17461","URSODEOXYCHOLIC ACID 500MG TAB","قرص اورسودئوکسی‌کولیک اسید ۵۰۰ میلی‌گرم",{"code":118,"en":119,"fa":120},"52876","URSODEOXYCHOLIC ACID SUSPENSION ORAL 250 mg\u002F5mL 250 mL","سوسپانسیون خوراکی اورسودئوکسی‌کولیک اسید ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۲۵۰ میلی‌لیتر",[122],{"source":123,"section":124,"url":125},"darooyab-generic","G-4337\u002FUrsodeoxycholic-Acid","https:\u002F\u002Fwww.darooyab.ir\u002FG-4337\u002FUrsodeoxycholic-Acid",[127,131,135,139,142],{"kind":128,"url":129,"label":130},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=019594","NDA019594",{"kind":132,"url":133,"label":134},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=a061bb07-a85d-4b08-877f-ce02156f0de7","FDA Ursodiol",{"kind":136,"url":137,"label":138},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699047.html","Ursodiol",{"kind":140,"url":141,"label":89},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=A05AA02",{"kind":143,"url":125,"label":144},"darooyab","Ursodeoxycholic-Acid",{"pregnancy":146,"lactation":155,"pediatric":163,"geriatric":172},{"level":147,"text":148,"quote":151,"refs":152},"caution",{"fa":149,"en":150},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Reproduction studies have been performed in rats and rabbits with ursodiol doses up to 200-fold the therapeutic dose and have revealed no evidence of impaired fertility or harm to the fetus at doses of 20- to 100-fold the human dose in rats and at 5-fold the human dose (highest dose tested) in rabbits.",[153],{"source":37,"section":154},"Pregnancy",{"level":147,"text":156,"quote":159,"refs":160},{"fa":157,"en":158},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk, caution should be exercised when ursodiol is administered to a nursing mother.",[161],{"source":37,"section":162},"Nursing Mothers",{"level":164,"text":165,"quote":168,"refs":169},"not-established",{"fa":166,"en":167},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","The safety and effectiveness of ursodiol in pediatric patients have not been established.",[170],{"source":37,"section":171},"Pediatric Use",{"level":147,"text":173,"quote":176,"refs":177},{"fa":174,"en":175},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Therefore, it is recommended that dosing proceed with caution in this population.",[178],{"source":37,"section":179},"Geriatric Use",{"kind":181,"refs":182,"id":130},"NDA authorized generic",[183],{"source":37,"section":184},"SPL approval \u002F marketing category",1792191865401]