[{"data":1,"prerenderedAt":285},["ShallowReactive",2],{"drug-valacyclovir":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":22,"regimens":56,"contraindications":152,"warnings":162,"renal":163,"monitoring":164,"interactions":165,"review":166,"examples":169,"atc":203,"iran":205,"links":225,"populations":246,"usApproval":280},"valacyclovir",1,{"fa":7,"en":8},"والاسیکلوویر","Valacyclovir","anti-infectives",{"fa":11,"en":12},"ضدویروس (پیش‌داروی آسیکلوویر)","Antiviral (acyclovir prodrug)",[14],{"name":15,"market":16},"Valtrex","US",[18,19,7,20,21],"valtrex","والترکس","تبخال","زونا",[23,37,45],{"id":24,"form":25,"route":26,"label":27,"concentration":28,"markets":32,"refs":33},"tab-500","tablet","oral","500 mg tablet",{"amount":29,"unit":30,"perUnit":25,"scored":31},500,"mg",false,[16],[34],{"source":35,"section":36},"fda-valacyclovir-1g","3",{"id":38,"form":25,"route":26,"label":39,"concentration":40,"markets":42,"refs":43},"tab-1000","1 g tablet (partially scored)",{"amount":41,"unit":30,"perUnit":25,"scored":31},1000,[16],[44],{"source":35,"section":36},{"id":46,"form":47,"route":26,"label":48,"concentration":49,"markets":51,"refs":52},"susp-50","suspension","50 mg\u002FmL extemporaneous suspension (from 500 mg tablets)",{"amount":50,"unit":30,"perVolumeMl":5},50,[16],[53],{"source":54,"section":55},"fda-valacyclovir","2.3",[57,77,91,103,113,133],{"id":58,"disease":59,"label":60,"population":63,"type":67,"unit":30,"dose":68,"refs":71,"durationDays":76},"cold-sore","herpes-labialis",{"fa":61,"en":62},"تبخال — ۱۲ سال به بالا: ۲ g هر ۱۲ ساعت، ۱ روز","Cold sores — ≥12 y: 2 g every 12 h for 1 day",{"minAge":64},{"value":65,"unit":66},12,"year","fixed",{"perDose":69,"dosesPerDay":70},2000,2,[72,74],{"source":54,"section":73},"2.1",{"source":54,"section":75},"2.2",{"min":5,"max":5},{"id":78,"disease":79,"label":80,"population":83,"type":67,"unit":30,"dose":86,"refs":87,"durationDays":89},"gh-initial","genital-herpes",{"fa":81,"en":82},"تبخال تناسلی، نوبت اول: ۱ g دو بار در روز، ۱۰ روز","Genital herpes, initial episode: 1 g twice daily for 10 days",{"minAge":84},{"value":85,"unit":66},18,{"perDose":41,"dosesPerDay":70},[88],{"source":54,"section":73},{"min":90,"max":90},10,{"id":92,"disease":79,"label":93,"population":96,"type":67,"unit":30,"dose":98,"refs":99,"durationDays":101},"gh-recurrent",{"fa":94,"en":95},"تبخال تناسلی عودکننده: ۵۰۰ mg دو بار در روز، ۳ روز","Recurrent genital herpes: 500 mg twice daily for 3 days",{"minAge":97},{"value":85,"unit":66},{"perDose":29,"dosesPerDay":70},[100],{"source":54,"section":73},{"min":102,"max":102},3,{"id":104,"disease":79,"label":105,"population":108,"type":67,"unit":30,"dose":110,"refs":111},"gh-suppress",{"fa":106,"en":107},"سرکوب تبخال تناسلی: ۱ g یک بار در روز","Genital herpes suppression: 1 g once daily",{"minAge":109},{"value":85,"unit":66},{"perDose":41,"dosesPerDay":5},[112],{"source":54,"section":73},{"id":114,"disease":115,"label":116,"population":119,"type":67,"unit":30,"dose":121,"refs":122,"durationDays":124,"notes":126},"zoster","herpes-zoster",{"fa":117,"en":118},"زونا: ۱ g سه بار در روز، ۷ روز","Herpes zoster: 1 g three times daily for 7 days",{"minAge":120},{"value":85,"unit":66},{"perDose":41,"dosesPerDay":102},[123],{"source":54,"section":73},{"min":125,"max":125},7,[127],{"text":128,"refs":131},{"fa":129,"en":130},"هر چه زودتر، ترجیحاً در ۴۸ ساعت اول بثورات.","Start as early as possible, ideally within 48 h of rash.",[132],{"source":54,"section":73},{"id":134,"disease":134,"label":135,"population":138,"type":141,"unit":30,"dose":142,"refs":145,"limits":147,"durationDays":150},"chickenpox",{"fa":136,"en":137},"آبله‌مرغان — ۲ تا ۱۷ سال: ۲۰ mg\u002Fkg سه بار در روز، ۵ روز","Chickenpox — 2–17 y: 20 mg\u002Fkg three times daily for 5 days",{"minAge":139,"maxAge":140},{"value":70,"unit":66},{"value":85,"unit":66},"weightBased",{"perKgPerDose":143,"intervalHours":144},20,8,[146],{"source":54,"section":75},{"maxPerDose":41,"refs":148},[149],{"source":54,"section":75},{"min":151,"max":151},5,[153],{"id":154,"severity":155,"text":156,"refs":159},"ci","block",{"fa":157,"en":158},"حساسیت شدید (آنافیلاکسی، واکنش پوستی شدید) به والاسیکلوویر یا آسیکلوویر.","Clinically significant hypersensitivity (anaphylaxis, SCARs) to valacyclovir or acyclovir.",[160],{"source":54,"section":161},"4",[],[],[],[],{"status":167,"reviewer":168,"date":168},"unverified",null,[170,174,178,181,185,190,193,200],{"regimen":58,"formulation":38,"input":171,"expect":173},{"ageYears":143,"weightKg":172},60,{"perDose":69,"tabletsPerDoseRounded":70},{"regimen":78,"formulation":38,"input":175,"expect":177},{"ageYears":176,"weightKg":172},25,{"perDose":41},{"regimen":92,"formulation":24,"input":179,"expect":180},{"ageYears":176,"weightKg":172},{"perDose":29},{"regimen":104,"formulation":38,"input":182,"expect":184},{"ageYears":183,"weightKg":172},30,{"perDay":41},{"regimen":114,"formulation":38,"input":186,"expect":188},{"ageYears":172,"weightKg":187},70,{"perDay":189},3000,{"regimen":134,"formulation":24,"input":191,"expect":192},{"ageYears":125,"weightKg":176},{"perDose":29},{"regimen":134,"formulation":46,"input":194,"expect":197},{"ageYears":195,"weightKg":196},4,15,{"perDose":198,"mlPerDose":199},300,6,{"regimen":134,"formulation":38,"input":201,"expect":202},{"ageYears":196,"weightKg":172},{"perDose":41},[204],"J05AB11",{"status":206,"forms":207,"refs":220},"registered",[208,212,216],{"code":209,"en":210,"fa":211},"10064","VALACICLOVIR 1000MG TAB","قرص والاسیکلوویر ۱۰۰۰ میلی‌گرم",{"code":213,"en":214,"fa":215},"16814","VALACICLOVIR 250MG TAB","قرص والاسیکلوویر ۲۵۰ میلی‌گرم",{"code":217,"en":218,"fa":219},"09161","VALACICLOVIR 500MG TAB","قرص والاسیکلوویر ۵۰۰ میلی‌گرم",[221],{"source":222,"section":223,"url":224},"darooyab-generic","G-1211\u002FValaciclovir","https:\u002F\u002Fwww.darooyab.ir\u002FG-1211\u002FValaciclovir",[226,230,234,237,240,243],{"kind":227,"url":228,"label":229},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=203047","ANDA203047",{"kind":231,"url":232,"label":233},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=2c2d5cec-038f-42bb-8f04-90d2431dc1c9","FDA Valacyclovir",{"kind":231,"url":235,"label":236},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=72300f70-57fd-42a8-a2dc-4cf95a1ce805","FDA Valacyclovir 1 g",{"kind":238,"url":239,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa695010.html",{"kind":241,"url":242,"label":204},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J05AB11",{"kind":244,"url":224,"label":245},"darooyab","Valaciclovir",{"pregnancy":247,"lactation":256,"pediatric":264,"geriatric":272},{"level":248,"text":249,"quote":252,"refs":253},"caution",{"fa":250,"en":251},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Clinical data over several decades with valacyclovir and its metabolite, acyclovir, in pregnant women, have not identified a drug associated risk of major birth defects.",[254],{"source":54,"section":255},"8.1",{"level":248,"text":257,"quote":260,"refs":261},{"fa":258,"en":259},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Although there is no information on the presence of valacyclovir in human milk, its metabolite, acyclovir, is present in human milk following oral administration of valacyclovir.",[262],{"source":54,"section":263},"8.2",{"level":248,"text":265,"quote":268,"refs":269},{"fa":266,"en":267},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The efficacy and safety of valacyclovir have not been established in pediatric patients: • aged less than 12 years with cold sores • aged less than 18 years with genital herpes • aged less than 18 years with herpes zoster • aged less than 2 years with chickenpox • for suppressive therapy following neonatal HSV …",[270],{"source":54,"section":271},"8.4",{"level":248,"text":273,"quote":276,"refs":277},{"fa":274,"en":275},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Elderly patients are also more likely to have renal or CNS adverse events [see Dosage and Administration ( 2.4 ), Warnings and Precautions ( 5.2 , 5.3 ), Clinical Pharmacology ( 12.3 )].",[278],{"source":54,"section":279},"8.5",{"kind":281,"refs":282,"id":229},"ANDA",[283],{"source":54,"section":284},"SPL approval \u002F marketing category",1792191872957]