[{"data":1,"prerenderedAt":282},["ShallowReactive",2],{"drug-valsartan":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":61,"contraindications":138,"warnings":159,"renal":160,"monitoring":168,"interactions":169,"review":170,"examples":173,"atc":192,"iran":194,"links":226,"populations":243,"usApproval":277},"valsartan",1,{"fa":7,"en":8},"والسارتان","Valsartan","cardiovascular",{"fa":11,"en":12},"مسدودکننده گیرنده آنژیوتانسین (ARB)","Angiotensin receptor blocker (ARB)",[14],{"name":15,"market":16},"Diovan","US",[18,19,7,20],"diovan","دیووان","ARB",[22,36,45,53],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-40","tablet","oral","40 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},40,"mg",true,[16],[33],{"source":34,"section":35},"fda-valsartan","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":42,"refs":43},"tab-80","80 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":41},80,false,[16],[44],{"source":34,"section":35},{"id":46,"form":24,"route":25,"label":47,"concentration":48,"markets":50,"refs":51},"tab-160","160 mg tablet",{"amount":49,"unit":29,"perUnit":24,"scored":41},160,[16],[52],{"source":34,"section":35},{"id":54,"form":24,"route":25,"label":55,"concentration":56,"markets":58,"refs":59},"tab-320","320 mg tablet",{"amount":57,"unit":29,"perUnit":24,"scored":41},320,[16],[60],{"source":34,"section":35},[62,88,114],{"id":63,"disease":64,"label":65,"population":68,"type":72,"unit":29,"dose":73,"refs":74,"limits":77,"notes":81},"adult-htn","hypertension",{"fa":66,"en":67},"فشار خون — بزرگسال: ۸۰ یا ۱۶۰ mg یک بار در روز","Hypertension — adults: 80 or 160 mg once daily",{"minAge":69},{"value":70,"unit":71},18,"year","fixed",{"perDose":40,"perDoseMax":49,"dosesPerDay":5},[75],{"source":34,"section":76},"2.2",{"maxPerDay":57,"refs":78},[79],{"source":34,"section":80},"2, Table",[82],{"text":83,"refs":86},{"fa":84,"en":85},"محدوده ۸۰ تا ۳۲۰ mg یک بار در روز.","Range 80–320 mg once daily.",[87],{"source":34,"section":76},{"id":89,"disease":64,"label":90,"population":93,"type":97,"unit":29,"dose":98,"refs":99,"limits":102,"notes":105},"peds-htn",{"fa":91,"en":92},"فشار خون — ۱ تا ۱۶ سال: ۱ mg\u002Fkg یک بار در روز (تا ۴۰ mg)","Hypertension — 1–16 y: 1 mg\u002Fkg once daily (up to 40 mg)",{"minAge":94,"maxAge":95},{"value":5,"unit":71},{"value":96,"unit":71},17,"weightBased",{"perKgPerDay":5,"dividedDoses":5},[100],{"source":34,"section":101},"2.3",{"maxPerDose":28,"refs":103},[104],{"source":34,"section":101},[106],{"text":107,"refs":110},{"fa":108,"en":109},"محدوده ۱ تا ۴ mg\u002Fkg یک بار (تا ۱۶۰ mg). برای ۱ تا ۵ سال یا وقتی دوز با قرص جور نیست، سوسپانسیون توصیه می‌شود.","Range 1–4 mg\u002Fkg once daily (up to 160 mg). Suspension recommended for ages 1–5 or when the dose does not match tablet strengths.",[111,112],{"source":34,"section":80},{"source":34,"section":113},"2.1",{"id":115,"disease":116,"label":117,"population":120,"type":72,"unit":29,"dose":122,"refs":124,"limits":127,"notes":130},"hf","heart-failure",{"fa":118,"en":119},"نارسایی قلبی — بزرگسال: شروع ۴۰ mg دو بار در روز","Heart failure — adults: start 40 mg twice daily",{"minAge":121},{"value":70,"unit":71},{"perDose":28,"dosesPerDay":123},2,[125],{"source":34,"section":126},"2.4",{"maxPerDay":57,"refs":128},[129],{"source":34,"section":126},[131],{"text":132,"refs":135},{"fa":133,"en":134},"محدوده ۴۰ تا ۱۶۰ mg دو بار؛ حداکثر ۳۲۰ mg\u002Fday در کارآزمایی‌ها.","Range 40–160 mg twice daily; max 320 mg\u002Fday in trials.",[136,137],{"source":34,"section":80},{"source":34,"section":126},[139,150],{"id":140,"severity":141,"rule":142,"text":144,"refs":147},"under-1","block",{"maxAge":143},{"value":5,"unit":71},{"fa":145,"en":146},"زیر ۱ سال توصیه نمی‌شود.","Not recommended under 1 year.",[148],{"source":34,"section":149},"8.4",{"id":151,"severity":152,"text":153,"refs":156},"pregnancy","warn",{"fa":154,"en":155},"هشدار جعبه‌ای: سمیت جنینی — با تشخیص بارداری فوراً قطع شود.","Boxed warning: fetal toxicity — stop as soon as pregnancy is detected.",[157],{"source":34,"section":158},"Boxed Warning",[],[161],{"egfrBelow":162,"severity":152,"text":163,"refs":166},30,{"fa":164,"en":165},"در کودکان با GFR کمتر از ۳۰ یا دیالیز داده‌ای نیست.","No data in children with GFR \u003C30 or on dialysis.",[167],{"source":34,"section":149},[],[],{"status":171,"reviewer":172,"date":172},"unverified",null,[174,178,182,187],{"regimen":63,"formulation":37,"input":175,"expect":177},{"ageYears":176,"weightKg":40},50,{"perDose":40,"upperPerDose":49},{"regimen":89,"formulation":23,"input":179,"expect":181},{"ageYears":180,"weightKg":28},12,{"perDose":28,"tabletsPerDoseRounded":5},{"regimen":89,"formulation":23,"input":183,"expect":186},{"ageYears":184,"weightKg":185},14,55,{"perDose":28},{"regimen":115,"formulation":23,"input":188,"expect":191},{"ageYears":189,"weightKg":190},65,70,{"perDay":40},[193],"C09CA03",{"status":195,"forms":196,"refs":221},"registered",[197,201,205,209,213,217],{"code":198,"en":199,"fa":200},"05561","VALSARTAN 160MG CAP","کپسول والسارتان ۱۶۰ میلی‌گرم",{"code":202,"en":203,"fa":204},"05766","VALSARTAN 160MG TAB","قرص والسارتان ۱۶۰ میلی‌گرم",{"code":206,"en":207,"fa":208},"07095","VALSARTAN 40MG CAP","کپسول والسارتان ۴۰ میلی‌گرم",{"code":210,"en":211,"fa":212},"09801","VALSARTAN 40MG TAB","قرص والسارتان ۴۰ میلی‌گرم",{"code":214,"en":215,"fa":216},"05560","VALSARTAN 80MG CAP","کپسول والسارتان ۸۰ میلی‌گرم",{"code":218,"en":219,"fa":220},"05423","VALSARTAN 80MG TAB","قرص والسارتان ۸۰ میلی‌گرم",[222],{"source":223,"section":224,"url":225},"darooyab-generic","G-1929\u002FValsartan","https:\u002F\u002Fwww.darooyab.ir\u002FG-1929\u002FValsartan",[227,231,235,238,241],{"kind":228,"url":229,"label":230},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204011","ANDA204011",{"kind":232,"url":233,"label":234},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f4a5df78-157b-4996-845c-235234250f11","FDA Valsartan",{"kind":236,"url":237,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa697015.html",{"kind":239,"url":240,"label":193},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=C09CA03",{"kind":242,"url":225,"label":8},"darooyab",{"pregnancy":244,"lactation":252,"pediatric":260,"geriatric":268},{"level":245,"text":246,"quote":249,"refs":250},"avoid",{"fa":247,"en":248},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","( 5.1 ) WARNING: FETAL TOXICITY See full prescribing information for complete boxed warning.",[251],{"source":34,"section":158},{"level":245,"text":253,"quote":256,"refs":257},{"fa":254,"en":255},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in breastfed infants from exposure to valsartan, advise a nursing woman that breastfeeding is not recommended during treatment with valsartan.",[258],{"source":34,"section":259},"8.2",{"level":261,"text":262,"quote":265,"refs":266},"caution",{"fa":263,"en":264},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Use of valsartan is not recommended in children less than 1 year of age.",[267],{"source":34,"section":149},{"level":269,"text":270,"quote":273,"refs":274},"ok",{"fa":271,"en":272},"برچسب: در سالمندان تفاوت یا تنظیم دوز خاصی ذکر نشده.","Label: no specific difference or dose adjustment stated for older adults.","Exposure [measured by area under the curve (AUC)] to valsartan is higher by 70% in the elderly than in the young, however no dosage adjustment is necessary [see Clinical Pharmacology (12.3) ] .",[275],{"source":34,"section":276},"8.5",{"kind":278,"refs":279,"id":230},"ANDA",[280],{"source":34,"section":281},"SPL approval \u002F marketing category",1792191868922]