[{"data":1,"prerenderedAt":188},["ShallowReactive",2],{"drug-varenicline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":20,"formulations":25,"regimens":47,"contraindications":73,"warnings":94,"renal":95,"monitoring":96,"interactions":97,"review":98,"examples":101,"atc":107,"iran":109,"links":129,"populations":149,"usApproval":183},"varenicline",1,{"fa":7,"en":8},"وارنیکلین","Varenicline","nervous-system",{"fa":11,"en":12},"آگونیست نسبی نیکوتینی","Nicotinic partial agonist",[14,17],{"name":15,"market":16},"Chantix","US",{"name":18,"market":19},"Champix","GB",[21,22,23,7,24],"chantix","champix","شمپیکس","ترک سیگار",[26,40],{"id":27,"form":28,"route":29,"label":30,"concentration":31,"markets":35,"refs":36},"tab-0-5","tablet","oral","0.5 mg tablet",{"amount":32,"unit":33,"perUnit":28,"scored":34},0.5,"mg",false,[16],[37],{"source":38,"section":39},"fda-varenicline","3",{"id":41,"form":28,"route":29,"label":42,"concentration":43,"markets":44,"refs":45},"tab-1","1 mg tablet",{"amount":5,"unit":33,"perUnit":28,"scored":34},[16],[46],{"source":38,"section":39},[48],{"id":49,"disease":50,"label":51,"population":54,"type":58,"unit":33,"dose":59,"refs":61,"durationDays":64,"notes":66},"quit","smoking-cessation",{"fa":52,"en":53},"ترک سیگار — هفته اول تیتراسیون، سپس ۱ mg دو بار","Smoking cessation — week-1 titration, then 1 mg twice daily",{"minAge":55},{"value":56,"unit":57},18,"year","fixed",{"perDose":5,"dosesPerDay":60},2,[62],{"source":38,"section":63},"2",{"min":65,"max":65},84,[67],{"text":68,"refs":71},{"fa":69,"en":70},"روز ۱ تا ۳: ۰٫۵ mg یک بار؛ روز ۴ تا ۷: ۰٫۵ mg دو بار؛ سپس ۱ mg دو بار تا ۱۲ هفته. CrCl کمتر از ۳۰: حداکثر ۰٫۵ mg دو بار.","Days 1–3: 0.5 mg once daily; days 4–7: 0.5 mg twice daily; then 1 mg twice daily to 12 weeks. CrCl \u003C30: max 0.5 mg twice daily.",[72],{"source":38,"section":63},[74,83],{"id":75,"severity":76,"text":77,"refs":80},"ci","block",{"fa":78,"en":79},"سابقه حساسیت یا واکنش پوستی جدی به وارنیکلین.","History of serious hypersensitivity or skin reactions to varenicline.",[81],{"source":38,"section":82},"4",{"id":84,"severity":76,"rule":85,"text":88,"refs":91},"child",{"maxAge":86},{"value":87,"unit":57},17,{"fa":89,"en":90},"در ۱۶ سال و کمتر توصیه نمی‌شود.","Not recommended in patients 16 years or younger.",[92],{"source":38,"section":93},"8.4",[],[],[],[],{"status":99,"reviewer":100,"date":100},"unverified",null,[102],{"regimen":49,"formulation":41,"input":103,"expect":106},{"ageYears":104,"weightKg":105},40,80,{"perDose":5,"perDay":60},[108],"N07BA03",{"status":110,"forms":111,"refs":124},"registered",[112,116,120],{"code":113,"en":114,"fa":115},"10674","VARENICLINE 1MG TAB","قرص وارنیکلین ۱ میلی‌گرم",{"code":117,"en":118,"fa":119},"10675","VARENICLINE 500MCG TAB","قرص وارنیکلین ۵۰۰ میکروگرم",{"code":121,"en":122,"fa":123},"16352","VARENICLINE 500MCG\u002F1MG TAB","قرص وارنیکلین ۵۰۰ میکروگرم \u002F ۱ میلی‌گرم",[125],{"source":126,"section":127,"url":128},"darooyab-generic","G-4345\u002FVarenicline","https:\u002F\u002Fwww.darooyab.ir\u002FG-4345\u002FVarenicline",[130,134,138,141,144,147],{"kind":131,"url":132,"label":133},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=218985","ANDA218985",{"kind":135,"url":136,"label":137},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=f2e57493-d099-4055-8e92-67611c8d20f4","FDA Varenicline",{"kind":139,"url":140,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa606024.html",{"kind":139,"url":142,"label":143},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa621057.html","Varenicline Nasal Spray",{"kind":145,"url":146,"label":108},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N07BA03",{"kind":148,"url":128,"label":8},"darooyab",{"pregnancy":150,"lactation":159,"pediatric":167,"geriatric":175},{"level":151,"text":152,"quote":155,"refs":156},"caution",{"fa":153,"en":154},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Available data have not suggested an increased risk for major birth defects following exposure to varenicline in pregnancy, compared with women who smoke [see Data] .",[157],{"source":38,"section":158},"8.1",{"level":151,"text":160,"quote":163,"refs":164},{"fa":161,"en":162},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary There are no data on the presence of varenicline in human milk, the effects on the breastfed infant, or the effects on milk production.",[165],{"source":38,"section":166},"8.2",{"level":168,"text":169,"quote":172,"refs":173},"not-established",{"fa":170,"en":171},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Varenicline tablets is not recommended for use in pediatric patients 16 years of age or younger because its efficacy in this population was not demonstrated.",[174],{"source":38,"section":93},{"level":151,"text":176,"quote":179,"refs":180},{"fa":177,"en":178},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function [see Dosage and Administration (2.2) ].",[181],{"source":38,"section":182},"8.5",{"kind":184,"refs":185,"id":133},"ANDA",[186],{"source":38,"section":187},"SPL approval \u002F marketing category",1792444713308]