[{"data":1,"prerenderedAt":204},["ShallowReactive",2],{"drug-vincristine":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":33,"contraindications":94,"warnings":104,"renal":111,"monitoring":112,"interactions":113,"review":114,"examples":117,"atc":136,"iran":138,"usApproval":154,"links":160,"populations":177},"vincristine",1,{"fa":7,"en":8},"وینکریستین","Vincristine","antineoplastic-immunomodulating",{"fa":11,"en":12},"آلکالوئید وینکا","Vinca alkaloid",[14],{"name":15,"market":16},"Oncovin","US",[18,19,7],"oncovin","انکووین",[21],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":28,"refs":29},"vial-1","injection","iv","1 mg\u002FmL (1 mg, 2 mg vials)",{"amount":5,"unit":27,"perVolumeMl":5},"mg",[16],[30],{"source":31,"section":32},"fda-vincristine","How Supplied",[34,66,79],{"id":35,"disease":36,"label":37,"population":40,"type":44,"unit":27,"dose":45,"refs":47,"durationDays":50,"notes":51},"adult","acute-lymphoblastic-leukemia",{"fa":38,"en":39},"بزرگسال (لوسمی حاد و سایر بدخیمی‌ها) — ۱٫۴ mg\u002Fm² وریدی هفتگی","Adults (acute leukaemia and other malignancies) — 1.4 mg\u002Fm² IV weekly",{"minAge":41},{"value":42,"unit":43},18,"year","bsa",{"perM2PerDay":46,"dividedDoses":5},1.4,[48],{"source":31,"section":49},"Dosage and Administration",{"min":5,"max":5},[52,60],{"text":53,"refs":56},{"fa":54,"en":55},"فقط وریدی — تزریق داخل نخاعی کشنده است. بیلی‌روبین مستقیم بالای ۳: ۵۰٪ دوز. محاسبه دوز با دقت زیاد (بیش‌مصرفی کشنده).","IV only — intrathecal injection is fatal. Direct bilirubin >3 mg\u002FdL: 50% dose. Calculate with extreme care (overdose can be fatal).",[57,58],{"source":31,"section":49},{"source":31,"section":59},"Warnings",{"text":61,"refs":64},{"fa":62,"en":63},"فقط زیر نظر پزشک متخصص شیمی‌درمانی و در مرکز مجهز. عدد ماشین‌حساب = mg\u002Fm² برچسب × سطح بدن (Mosteller)؛ پروتکل، فاصله دوره‌ها، تنظیم بر اساس CBC و عملکرد کلیه\u002Fکبد با تیم انکولوژی.","Only under an oncologist in an equipped centre. Calculator = label mg\u002Fm² × BSA (Mosteller); protocol, cycle interval and adjustment for CBC and renal\u002Fhepatic function rest with the oncology team.",[65],{"source":31,"section":49},{"id":67,"disease":36,"label":68,"population":71,"type":44,"unit":27,"dose":74,"refs":76,"durationDays":78},"child",{"fa":69,"en":70},"کودک — ۱٫۵ تا ۲ mg\u002Fm² وریدی هفتگی (≤۱۰ kg: ۰٫۰۵ mg\u002Fkg)","Children — 1.5–2 mg\u002Fm² IV weekly (≤10 kg: 0.05 mg\u002Fkg)",{"maxAge":72,"minWeightKg":73},{"value":42,"unit":43},10.01,{"perM2PerDay":75,"dividedDoses":5},1.5,[77],{"source":31,"section":49},{"min":5,"max":5},{"id":80,"disease":36,"label":81,"population":84,"type":87,"unit":27,"dose":88,"refs":91,"durationDays":93},"infant",{"fa":82,"en":83},"کودک ۱۰ kg یا کمتر — شروع ۰٫۰۵ mg\u002Fkg هفتگی","Children ≤10 kg — start 0.05 mg\u002Fkg weekly",{"maxAge":85,"maxWeightKg":86},{"value":42,"unit":43},10,"weightBased",{"perKgPerDose":89,"intervalHours":90},0.05,24,[92],{"source":31,"section":49},{"min":5,"max":5},[95],{"id":96,"severity":97,"text":98,"refs":101},"ci","block",{"fa":99,"en":100},"فرم دمیلینه‌کننده سندرم شارکو-ماری-توث.","Demyelinating form of Charcot–Marie–Tooth syndrome.",[102],{"source":31,"section":103},"Contraindications",[105],{"text":106,"refs":109},{"fa":107,"en":108},"هشدار جعبه‌ای: فقط وریدی — داخل نخاعی کشنده؛ نشت به بافت تحریک شدید. نوروتوکسیسیتی وابسته به دوز.","Boxed warning: IV only — fatal if given intrathecally; extravasation causes severe irritation. Dose-related neurotoxicity.",[110],{"source":31,"section":59},[],[],[],{"status":115,"reviewer":116,"date":116},"unverified",null,[118,125,131],{"regimen":35,"formulation":22,"input":119,"expect":123},{"ageYears":120,"weightKg":121,"heightCm":122},55,80,180,{"perDose":124,"mlPerDose":124},2.8,{"regimen":67,"formulation":22,"input":126,"expect":130},{"ageYears":127,"weightKg":128,"heightCm":129},12,25,144,{"perDose":75,"mlPerDose":75},{"regimen":80,"formulation":22,"input":132,"expect":134},{"ageMonths":86,"weightKg":133},8,{"perDose":135,"mlPerDose":135},0.4,[137],"L01CA02",{"status":139,"forms":140,"refs":149},"registered",[141,145],{"code":142,"en":143,"fa":144},"01284","VINCRISTINE SULFATE 1MG VIAL","ویال وین‌کریستین سولفات ۱ میلی‌گرم",{"code":146,"en":147,"fa":148},"02194","VINCRISTINE SULFATE 1MG\u002FML AMP","آمپول وین‌کریستین سولفات ۱ میلی‌گرم \u002F میلی‌لیتر",[150],{"source":151,"section":152,"url":153},"darooyab-generic","G-1091\u002FVincristine","https:\u002F\u002Fwww.darooyab.ir\u002FG-1091\u002FVincristine",{"kind":155,"refs":156,"id":159},"ANDA",[157],{"source":31,"section":158},"SPL approval \u002F marketing category","ANDA071484",[161,164,168,172,175],{"kind":162,"url":163,"label":159},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=071484",{"kind":165,"url":166,"label":167},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b22e4c8e-dbe1-4d4b-a026-e1812974071c","FDA Vincristine",{"kind":169,"url":170,"label":171},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682822.html","Vincristine Injection",{"kind":173,"url":174,"label":137},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=L01CA02",{"kind":176,"url":153,"label":8},"darooyab",{"pregnancy":178,"lactation":187,"pediatric":196},{"level":179,"text":180,"quote":183,"refs":184},"avoid",{"fa":181,"en":182},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Vincristine sulfate can cause fetal harm when administered to a pregnant woman.",[185],{"source":31,"section":186},"Pregnancy",{"level":188,"text":189,"quote":192,"refs":193},"caution",{"fa":190,"en":191},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Because many drugs are excreted in human milk and because of the potential for serious adverse reactions due to vincristine sulfate in nursing infants, a decision should be made either to discontinue nursing or the drug, taking into account the importance of the drug to the mother.",[194],{"source":31,"section":195},"Nursing Mothers",{"level":188,"text":197,"quote":200,"refs":201},{"fa":198,"en":199},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See DOSAGE AND ADMINISTRATION section.",[202],{"source":31,"section":203},"Pediatric Use",1792444707704]