[{"data":1,"prerenderedAt":254},["ShallowReactive",2],{"drug-ziprasidone":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":20,"regimens":59,"contraindications":100,"warnings":129,"renal":130,"monitoring":131,"interactions":132,"review":133,"examples":136,"atc":145,"iran":147,"links":188,"populations":208,"usApproval":249},"ziprasidone",1,{"fa":7,"en":8},"زیپراسیدون","Ziprasidone","nervous-system",{"fa":11,"en":12},"آنتی‌سایکوتیک آتیپیک","Atypical antipsychotic",[14],{"name":15,"market":16},"Geodon","US",[18,19,7],"geodon","ژئودون",[21,35,43,51],{"id":22,"form":23,"route":24,"label":25,"concentration":26,"markets":30,"refs":31},"cap-20","capsule","oral","20 mg capsule",{"amount":27,"unit":28,"perUnit":23,"scored":29},20,"mg",false,[16],[32],{"source":33,"section":34},"fda-ziprasidone","3",{"id":36,"form":23,"route":24,"label":37,"concentration":38,"markets":40,"refs":41},"cap-40","40 mg capsule",{"amount":39,"unit":28,"perUnit":23,"scored":29},40,[16],[42],{"source":33,"section":34},{"id":44,"form":23,"route":24,"label":45,"concentration":46,"markets":48,"refs":49},"cap-60","60 mg capsule",{"amount":47,"unit":28,"perUnit":23,"scored":29},60,[16],[50],{"source":33,"section":34},{"id":52,"form":23,"route":24,"label":53,"concentration":54,"markets":56,"refs":57},"cap-80","80 mg capsule",{"amount":55,"unit":28,"perUnit":23,"scored":29},80,[16],[58],{"source":33,"section":34},[60,88],{"id":61,"disease":62,"label":63,"population":66,"type":70,"unit":28,"dose":71,"refs":73,"limits":76,"notes":81},"scz","schizophrenia",{"fa":64,"en":65},"اسکیزوفرنی — ۲۰ mg دو بار با غذا","Schizophrenia — 20 mg twice daily with food",{"minAge":67},{"value":68,"unit":69},18,"year","fixed",{"perDose":27,"dosesPerDay":72},2,[74],{"source":33,"section":75},"2.2",{"maxPerDay":77,"refs":78},200,[79],{"source":33,"section":80},"2",[82],{"text":83,"refs":86},{"fa":84,"en":85},"تا ۸۰ mg دو بار؛ تا ۱۰۰ mg دو بار مطالعه شده.","Up to 80 mg twice daily; studied up to 100 mg twice daily.",[87],{"source":33,"section":80},{"id":89,"disease":90,"label":91,"population":94,"type":70,"unit":28,"dose":96,"refs":97},"mania","bipolar-mania",{"fa":92,"en":93},"مانیا\u002Fحالت مختلط — ۴۰ mg دو بار با غذا","Mania\u002Fmixed episode — 40 mg twice daily with food",{"minAge":95},{"value":68,"unit":69},{"perDose":39,"dosesPerDay":72},[98],{"source":33,"section":99},"2.3",[101,110,119],{"id":102,"severity":103,"text":104,"refs":107},"qt","block",{"fa":105,"en":106},"سابقه افزایش QT، MI اخیر، نارسایی قلبی جبران‌نشده یا مصرف داروهای طولانی‌کننده QT.","Known QT prolongation, recent MI, uncompensated heart failure, or other QT-prolonging drugs.",[108],{"source":33,"section":109},"4",{"id":111,"severity":112,"text":113,"refs":116},"dementia","warn",{"fa":114,"en":115},"هشدار جعبه‌ای: افزایش مرگ در سالمندان مبتلا به سایکوز ناشی از دمانس.","Boxed warning: increased mortality in elderly patients with dementia-related psychosis.",[117],{"source":33,"section":118},"Boxed Warning",{"id":120,"severity":103,"rule":121,"text":123,"refs":126},"child",{"maxAge":122},{"value":68,"unit":69},{"fa":124,"en":125},"در کودکان ثابت نشده.","Not established in children.",[127],{"source":33,"section":128},"8.4",[],[],[],[],{"status":134,"reviewer":135,"date":135},"unverified",null,[137,142],{"regimen":61,"formulation":22,"input":138,"expect":141},{"ageYears":139,"weightKg":140},30,70,{"perDose":27},{"regimen":89,"formulation":36,"input":143,"expect":144},{"ageYears":139,"weightKg":140},{"perDose":39},[146],"N05AE04",{"status":148,"forms":149,"refs":183},"registered",[150,154,158,162,165,169,173,177,180],{"code":151,"en":152,"fa":153},"16684","ZIPRASIDONE 40MG CAP","کپسول زیپراسیدون ۴۰ میلی‌گرم",{"code":155,"en":156,"fa":157},"11971","ZIPRASYDON 20MG CAP","کپسول زیپراسیدون ۲۰ میلی‌گرم",{"code":159,"en":160,"fa":161},"08512","ZIPRASYDON 20MG\u002FML VIAL","ویال زیپراسیدون ۲۰ میلی‌گرم \u002F میلی‌لیتر",{"code":163,"en":164,"fa":153},"07802","ZIPRASYDON 40MG CAP",{"code":166,"en":167,"fa":168},"08326","ZIPRASYDON 40MG TAB","قرص زیپراسیدون ۴۰ میلی‌گرم",{"code":170,"en":171,"fa":172},"08304","ZIPRASYDON 60MG CAP","کپسول زیپراسیدون ۶۰ میلی‌گرم",{"code":174,"en":175,"fa":176},"07796","ZIPRASYDON 80MG CAP","کپسول زیپراسیدون ۸۰ میلی‌گرم",{"code":178,"en":179,"fa":153},"52520","ZIPRASIDONE CAPSULE ORAL 40 mg",{"code":181,"en":182,"fa":176},"52170","ZIPRASIDONE CAPSULE ORAL 80 mg",[184],{"source":185,"section":186,"url":187},"darooyab-generic","G-1369\u002FZiprasidone","https:\u002F\u002Fwww.darooyab.ir\u002FG-1369\u002FZiprasidone",[189,193,197,200,203,206],{"kind":190,"url":191,"label":192},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=020825","NDA020825",{"kind":194,"url":195,"label":196},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=8326928a-2cb6-4f7f-9712-03a425a14c37","FDA Geodon",{"kind":198,"url":199,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa699062.html",{"kind":198,"url":201,"label":202},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa615047.html","Ziprasidone Injection",{"kind":204,"url":205,"label":146},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N05AE04",{"kind":207,"url":187,"label":8},"darooyab",{"pregnancy":209,"lactation":218,"pediatric":226,"geriatric":233,"reproductive":241},{"level":210,"text":211,"quote":214,"refs":215},"caution",{"fa":212,"en":213},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Risk Summary Neonates exposed to antipsychotic drugs, including GEODON, during the third trimester are at risk for extrapyramidal and\u002For withdrawal symptoms following delivery (see Clinical Considerations ) .",[216],{"source":33,"section":217},"8.1",{"level":210,"text":219,"quote":222,"refs":223},{"fa":220,"en":221},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Risk Summary Limited data from a published case report indicate the presence of ziprasidone in human milk.",[224],{"source":33,"section":225},"8.2",{"level":210,"text":227,"quote":230,"refs":231},{"fa":228,"en":229},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of Geodon have not been established in pediatric patients.",[232],{"source":33,"section":128},{"level":234,"text":235,"quote":238,"refs":239},"avoid",{"fa":236,"en":237},"برچسب: در سالمندان هشدار جدی یا پرهیز.","Label: serious warning or avoid in older adults.","Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death.",[240],{"source":33,"section":118},{"level":210,"text":242,"quote":245,"refs":246},{"fa":243,"en":244},"برچسب نکته‌ای درباره بارداری، پیشگیری یا باروری زنان و مردان دارد.","Label has advice on pregnancy testing, contraception or fertility for females and males.","Infertility Females Based on the pharmacologic action of ziprasidone (D2 antagonism), treatment with GEODON may result in an increase in serum prolactin levels, which may lead to a reversible reduction in fertility in females of reproductive potential [see Warnings and Precautions (5.15) and Nonclinical Toxicology …",[247],{"source":33,"section":248},"8.3",{"kind":250,"refs":251,"id":192},"NDA",[252],{"source":33,"section":253},"SPL approval \u002F marketing category",1792191877372]