Acute coronary syndrome / post-MI

Acute MI — accelerated weight-based regimen (max 100 mg)

PCI in HIT — infusion 25 mcg/kg/min (plus a 350 mcg/kg bolus)

PCI — 0.75 mg/kg bolus, then 1.75 mg/kg/h infusion for the procedure

PCI — 30 mcg/kg bolus before PCI

Infusion 4 mcg/kg/min right after the bolus, ≥2 h or the duration of PCI

LV dysfunction after MI — start 6.25 mg twice daily

ACS — loading dose 300 mg (once)

ACS — maintenance 75 mg once daily

Unstable angina and non-Q-wave MI — 120 units/kg every 12 h (max 10,000 units)

Acute MI (within 24 h) — 5 mg, then 5 mg, then 10 mg daily

Post-MI — maintenance 100 mg twice daily

ACS managed with PCI — 10 mg daily (after a 60 mg load)

Weight <60 kg — 5 mg daily (after a 60 mg load)

Acute MI, DVT, pulmonary embolism, arterial thromboembolism

Acute STEMI — single weight-based bolus, max 50 mg

ACS — 180 mg loading dose

ACS or prior MI — 90 mg twice daily (first year), then 60 mg twice daily