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Acute lymphoblastic leukaemia (ALL)
Acute lymphoblastic leukaemia (ALL) · ICD-10: C91.0
Symptoms
- • Bone and joint pain
- • Easy bruising and bleeding, petechiae
- • Weakness, tiredness and pallor
- • Fever and night sweats
- • Appetite and weight loss
- • Swollen lymph nodes and fullness below the ribs (enlarged liver/spleen)
Drugs and regimens
Blinatumomab⚠ Unverified
B-cell precursor ALL (MRD-positive, relapsed/refractory or consolidation) — continuous IV infusion for 28 days, then 14 days off
Mercaptopurine⚠ Unverified
ALL — combination maintenance: 1.5–2.5 mg/kg once daily
Methotrexate (oral)⚠ Unverified
Meningeal leukaemia (prophylaxis/treatment) — intrathecal, under 1 year: 6 mg
Methotrexate (oral)⚠ Unverified
Meningeal leukaemia — intrathecal, 1 to <2 years: 8 mg
Methotrexate (oral)⚠ Unverified
Meningeal leukaemia — intrathecal, 2 to <3 years: 10 mg
Methotrexate (oral)⚠ Unverified
Meningeal leukaemia — intrathecal, 3 years and older: 12 mg (≥9 years 12–15 mg)
Methotrexate (oral)⚠ Unverified
Acute lymphoblastic leukaemia — part of a multi-drug regimen, 10–5000 mg/m²
Vincristine⚠ Unverified
Adults (acute leukaemia and other malignancies) — 1.4 mg/m² IV weekly
Vincristine⚠ Unverified
Children — 1.5–2 mg/m² IV weekly (≤10 kg: 0.05 mg/kg)
Vincristine⚠ Unverified
Children ≤10 kg — start 0.05 mg/kg weekly