Invasive fungal infection (aspergillosis, candidaemia, cryptococcosis) — hospital

Life-threatening systemic fungal infection — start 0.25 mg/kg/day, up to 0.5–0.7 mg/kg/day

Empirical therapy (febrile neutropenia) — 3 mg/kg/day

Aspergillus, Candida, Cryptococcus — 3–5 mg/kg/day

Cryptococcal meningitis in HIV — 6 mg/kg/day

Candidaemia — adult: day 1 loading 200 mg

Candidaemia — adult: 100 mg daily from day 2, ≥14 days after the last positive culture

Candidaemia — children ≥1 month: day 1 3 mg/kg (max 200), then 1.5 mg/kg daily (max 100)

Candidaemia, febrile neutropenia, refractory aspergillosis — adult: day 1 loading 70 mg

Adult maintenance — 50 mg once daily from day 2

Children 3 months–17 y — day 1: 70 mg/m², then 50 mg/m² daily (max 70 mg)

Serious Candida or Cryptococcus infection (with amphotericin B) — 50–150 mg/kg/day every 6 h

Invasive aspergillosis — adult: maintenance 372 mg once daily (after loading)

Candidaemia and disseminated candidiasis — adult 100 mg daily

Candida prophylaxis in HSCT — adult 50 mg daily

Candidaemia — children ≥4 months: 2 mg/kg daily (max 100 mg)

Aspergillus/Candida prophylaxis (severe immunosuppression) — tablets: 300 mg twice on day 1, then 300 mg once daily

Invasive aspergillosis — tablets: 300 mg twice on day 1, then 300 mg once daily (6–12 weeks)

Prophylaxis — suspension: 200 mg (5 mL) three times daily

Adults and ≥15 y — maintenance 4 mg/kg every 12 h (after loading)

Child 2 to <12 y — maintenance 8 mg/kg every 12 h (after loading)