Doz

Malignant hyperthermia

Malignant hyperthermia · ICD-10: T88.3

Symptoms

  • • Rapid rise in body temperature to 40.6 °C or higher (during anaesthesia)
  • • Muscle rigidity and stiffness
  • • Unexplained muscle aches
  • • Dark brown urine (myoglobin)
  • • Bleeding

MedlinePlus · Symptoms

Drugs and regimens

Dantrolene⚠ Unverified

Treatment of malignant hyperthermia — at least 1 mg/kg IV push; repeat up to 10 mg/kg cumulative

Dantrolene⚠ Unverified

Prevention in high-risk patients — 2.5 mg/kg IV about 75 min before surgery

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