Major depressive disorder

Adult major depression — 25 mg at bedtime; 50 mg if no improvement after 2 weeks

Depression — adult outpatients: 75 mg/day divided

Depression — adolescents and elderly: 10 mg three times daily + 20 mg at bedtime

Under 12 years

MDD (adjunct) — start 0.5 or 1 mg, target 2 mg (max 3)

MDD — adults: 150 mg morning, 300 after 4 days

MDD (adjunct to antidepressant) — 1.5 mg, up to 3 mg on day 15

MDD — adults: 20 mg daily (max 40)

Children

Major depressive disorder — 50 mg once daily

Depression/anxiety — 25 mg three times or 75 mg once daily

Major depression — 40–60 mg/day

MDD — ≥12 years: 10 mg daily (max 20)

Treatment-resistant depression — 56 or 84 mg twice weekly (induction), then less often

MDD — children/adolescents (≥8 y): start 10 or 20 mg

MDD — adults: 20 mg in the morning

Depression — adult outpatients: 75 mg/day (up to 150)

Major depressive disorder, adults — 40–120 mg once daily

MDD — adults: 15 mg at night (max 45)

Major depressive disorder, adults — start 100 mg twice daily; effective range 300–600 mg/day

Depression — adults: 25 mg three or four times daily

Adolescents and elderly: 30–50 mg/day

Major depression — 20 mg daily (max 50)

Depression (atypical, non-endogenous or neurotic), adults — start 15 mg three times daily

Bipolar depression — adults: 50 mg at bedtime, target 300

MDD — adults: start 50 mg

Major depressive disorder without adequate response to other antidepressants, adults — 30 mg/day in divided doses

MDD — adults: 150 mg/day divided

MDD — adults: 75 mg daily

Major depressive disorder, adults — target 20–40 mg once daily with food

Major depression — start 10 mg once daily, then 20 mg