Multiple sclerosis (relapsing)
Multiple sclerosis (relapsing) · ICD-10: G35
Symptoms
- • Attacks lasting days to months followed by remissions
- • Weakness, numbness, tingling or burning in the limbs
- • Loss of balance, trouble walking and coordinating, tremor
- • Vision loss (usually one eye), double vision
- • Bladder and bowel problems: urgency, frequency, incontinence, constipation
- • Fatigue, depression, memory and attention problems
- • Worsened by fever, hot baths, sun or stress
Drugs and regimens
Relapsing MS, adults — cumulative 3.5 mg/kg over 2 yearly courses (1.75 mg/kg per course in two 4–5-day cycles)
Relapsing MS — 120 mg twice daily for 7 days, then 240 mg twice daily
Relapsing MS (≥10 y) — >40 kg: 0.5 mg; ≤40 kg: 0.25 mg once daily
Relapsing MS, adults — 20 mg SC daily
Relapsing MS, adults — 40 mg SC three times a week (at least 48 h apart)
Relapsing MS, adults — 30 mcg IM once a week
Relapsing MS, adults — 300 mg IV infusion over 1 h every 4 weeks
Relapsing or primary progressive MS — start: two infusions 2 weeks apart; ≥35 kg: 300 mg each; children ≥10 y, 25–<35 kg: 150 mg
Maintenance every 6 months — ≥35 kg: 600 mg; 25–<35 kg: 300 mg
Relapsing MS, adults — 20 mg SC at weeks 0, 1 and 2, then monthly from week 4
Relapsing MS, adults — 0.92 mg once daily from day 8 after a 7-day titration
Relapsing MS, adults (CYP2C9 *1/*1, *1/*2, *2/*2) — maintenance 2 mg once daily from day 6 after a 5-day titration
Relapsing MS — 7 or 14 mg once daily