Rheumatoid arthritis

Rheumatoid arthritis · ICD-10: M06.9

Symptoms

  • • Joint pain and stiffness on both sides of the body
  • • Morning stiffness lasting more than an hour
  • • Warm, tender, swollen joints
  • • Fatigue
  • • Loss of range of motion and deformity over time
  • • Dry eyes and mouth

MedlinePlus · Symptoms

Drugs and regimens

Abatacept⚠ Unverified

RA or PsA, adults (IV) — weeks 0, 2, 4 then every 4 weeks; <60 kg: 500, 60–100: 750, >100: 1000 mg

Abatacept⚠ Unverified

RA or PsA, adults (SC) — 125 mg once weekly

Adalimumab⚠ Unverified

RA, PsA, ankylosing spondylitis — adult 40 mg every other week

Anakinra⚠ Unverified

Rheumatoid arthritis, adults — 100 mg SC daily

Azathioprine⚠ Unverified

Rheumatoid arthritis — start about 1 mg/kg daily (50–100 mg)

Baricitinib⚠ Unverified

Rheumatoid arthritis — 2 mg once daily

Celecoxib⚠ Unverified

Rheumatoid arthritis — 100–200 mg twice daily

Certolizumab pegol⚠ Unverified

Loading (RA, PsA, axSpA, Crohn) — 400 mg (two 200 mg injections) at weeks 0, 2 and 4

Certolizumab pegol⚠ Unverified

Maintenance RA or PsA — 200 mg every 2 weeks (or 400 mg every 4 weeks)

Cyclosporine (oral, modified)⚠ Unverified

Rheumatoid arthritis — start 2.5 mg/kg/day in two doses

Diclofenac sodium⚠ Unverified

Rheumatoid arthritis — 75 mg twice daily (150–200 mg/day)

Etanercept⚠ Unverified

RA, PsA, ankylosing spondylitis — 50 mg once WEEKLY

Etoricoxib⚠ Unverified

Rheumatoid arthritis — 60 mg once daily (max 90 mg)

Golimumab⚠ Unverified

RA (with methotrexate), PsA or AS, adults — 50 mg SC once a month

Hydroxychloroquine⚠ Unverified

Rheumatoid arthritis — start 400–600 mg daily

Indomethacin⚠ Unverified

RA, OA, ankylosing spondylitis — 25 mg two or three times daily

Infliximab⚠ Unverified

Rheumatoid arthritis — 3 mg/kg per infusion with methotrexate

Leflunomide⚠ Unverified

Rheumatoid arthritis — loading 100 mg daily for 3 days (low hepatic/marrow risk)

Leflunomide⚠ Unverified

Rheumatoid arthritis — maintenance 20 mg once daily (10 mg if not tolerated)

Meloxicam⚠ Unverified

Rheumatoid arthritis — 7.5 mg once daily (up to 15 mg)

Methotrexate (oral)⚠ Unverified

Rheumatoid arthritis — start 7.5 mg once weekly

Rituximab⚠ Unverified

Rheumatoid arthritis — two 1000 mg infusions 2 weeks apart (with methotrexate)

Sulfasalazine⚠ Unverified

Rheumatoid arthritis — 2 g/day in 2 doses

Tocilizumab⚠ Unverified

Rheumatoid arthritis, adults (IV) — start 4 mg/kg every 4 weeks; increase to 8 mg/kg

Tocilizumab⚠ Unverified

Rheumatoid arthritis, adults (SC) — 162 mg every other week (<100 kg; may increase to weekly) or weekly (≥100 kg)

Tofacitinib⚠ Unverified

RA, PsA, AS — 5 mg twice daily (or XR 11 mg once daily)

Upadacitinib⚠ Unverified

Rheumatoid arthritis — 15 mg once daily

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