Sepsis / serious hospital infection (refer)

Adults, children and older infants with normal renal function — 15 mg/kg/day in 2–3 doses

Newborn — load 10 mg/kg then 7.5 mg/kg every 12 h

Severe or life-threatening infection (Pseudomonas) — adult 2 g every 6–8 h

Children 9 months–16 y — 30 mg/kg every 6–8 h (max 120 mg/kg/day)

Child 1 month–12 y, <50 kg — 50–180 mg/kg/day in 4–6 doses

Adult — 1 g every 12 h up to 2 g every 4 h by severity

Child 1 month–12 y — 30–50 mg/kg every 8 h (max 6 g/day)

Adult — usually 1 g every 8–12 h

Susceptible Gram-negative infection (adults and children) — 2.5–5 mg/kg/day colistin base in 2–4 doses

S. aureus bacteraemia (incl. right-sided endocarditis) — adult 6 mg/kg every 24 h, 2–6 weeks

Bacteraemia — children 12–17 y: 7 mg/kg every 24 h

Bacteraemia — children 7–11 y: 9 mg/kg every 24 h

Bacteraemia — children 1–6 y: 12 mg/kg every 24 h

Serious infections, adult (CrCl ≥90) — 500 mg every 6 h (or 1 g every 8 h)

Child ≥3 months (non-CNS) — 15–25 mg/kg every 6 h

Adult — serious streptococcal infections: 12–24 million units/day

IV — child: 10 mg/kg every 6 h (infuse over ≥60 min)

IV — adult: 500 mg every 6 h or 1 g every 12 h