Skin and skin structure infection
Skin and skin structure infection · ICD-10: L08.9
Symptoms
- • Skin redness or inflammation that gets bigger
- • Pain or tenderness in the area
- • Warm skin in the red area
- • Tight, glossy, stretched skin
- • Fever with chills and sweating
- • Fatigue
Drugs and regimens
Adult — 1.5–3 g (combined) every 6 h
Child ≥1 y — 300 mg/kg/day (combined) IV in 4 doses
Skin infection — adults: 1 g per day
Adult — moderate to severe infection: 500 mg–1 g every 6–8 h
Child >1 month — 25–50 mg/kg/day in 3–4 doses
Uncomplicated skin infection — 6 mo–12 y: 7 mg/kg every 12 h, 10 days
Moderate–severe skin infection — adult 2 g every 12 h
Skin infection — children: 50–75 mg/kg/day once (max 2 g/day)
Skin, respiratory, GU, bone — 25–50 mg/kg/day, every 6 h
Skin, respiratory, GU, bone — 25–50 mg/kg/day, every 12 h
Skin and skin structure: 500–750 mg every 12 h, 7–14 days
Uncomplicated skin infection
Methicillin-susceptible staphylococcal infections (skin and soft tissue, etc.)
cSSSI — adult 4 mg/kg every 24 h, 7–14 days
cSSSI — children 12–17 y: 5 mg/kg every 24 h
cSSSI — children 7–11 y: 7 mg/kg every 24 h
cSSSI — children 2–6 y: 9 mg/kg every 24 h
cSSSI — children 1–<2 y: 10 mg/kg every 24 h
Staphylococcal infection — adults: 125 mg every 6 h (severe 250)
Staphylococcal infection — <40 kg: 12.5 mg/kg/day (severe 25) in 4 doses
Superficial skin infection — three or four times daily
Uncomplicated skin infection: 500 mg daily, 7–10 days
Complicated skin and skin-structure infection — adult 500 mg every 8 h
cSSSI — child ≥3 months: 10 mg/kg every 8 h (max 500 mg)
Mild staph skin infection — ≥12 y: 250–500 mg every 6–8 h
Acute bacterial skin infection — 200 mg once daily for 6 days (oral or IV)