Susceptible bacterial infections (general)

Adults: 1–2 g once daily

Susceptible infections — adults: 100 mg every 12 h on day 1, then 100 mg/day

Less severe infection — >8 y and <45 kg: maintenance 2.2 mg/kg/day

Severe/life-threatening (e.g. anthrax, RMSF) — <45 kg: 2.2 mg/kg every 12 h

Susceptible infections — child >8 y, <45 kg: 4.4 mg/kg in 2 doses on day 1, then 2.2 mg/kg daily

Serious infection — adults: 3 mg/kg/day in 3 doses (every 8 h)

Children: 2–2.5 mg/kg every 8 h

Infants and neonates (>1 week): 2.5 mg/kg every 8 h

Neonates ≤1 week: 2.5 mg/kg every 12 h

Adult — 200 mg first, then 100 mg every 12 h

Child >8 y — 4 mg/kg first, then 2 mg/kg every 12 h

Adult — 500 mg twice or 250 mg four times daily

Child >8 y — 25–50 mg/kg/day in 4 doses