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no efficacy data if started after 24 hours.",[106],{"source":33,"section":92},[22,36,47,55],{"id":109,"disease":77,"label":110,"population":113,"type":115,"unit":28,"dose":116,"refs":118,"durationDays":120,"allowedFormulations":121},"chickenpox-adult",{"fa":111,"en":112},"آبله‌مرغان — بزرگسال و بالای ۴۰ kg: ۸۰۰ mg چهار بار در روز","Chickenpox — adults and >40 kg: 800 mg four times daily",{"minWeightKg":114},40.01,"fixed",{"perDose":50,"dosesPerDay":117},4,[119],{"source":33,"section":92},{"min":29,"max":29},[22,36,47,55],{"id":123,"disease":124,"label":125,"population":128,"type":115,"unit":28,"dose":131,"refs":132,"durationDays":134,"allowedFormulations":137,"notes":138},"zoster","herpes-zoster",{"fa":126,"en":127},"زونا — ۸۰۰ mg پنج بار در روز (هر ۴ ساعت)، ۷ تا ۱۰ روز","Herpes zoster — 800 mg five times daily (every 4 h), 7–10 days",{"minAge":129},{"value":130,"unit":84},18,{"perDose":50,"dosesPerDay":29},[133],{"source":45,"section":92},{"min":135,"max":136},7,10,[36,47,55],[139],{"text":140,"refs":143},{"fa":141,"en":142},"نارسایی کلیه: کاهش دوز طبق جدول ۳ برچسب (مثلاً ۸۰۰ mg: CrCl ۱۰ تا ۲۵ هر ۸ ساعت، زیر ۱۰ هر ۱۲ ساعت).","Renal impairment: reduce per label Table 3 (e.g. 800 mg: CrCl 10–25 every 8 h, \u003C10 every 12 h).",[144],{"source":45,"section":92},{"id":146,"disease":147,"label":148,"population":151,"type":115,"unit":28,"dose":153,"refs":154,"durationDays":156,"allowedFormulations":157,"notes":158},"gh-initial","genital-herpes",{"fa":149,"en":150},"تبخال تناسلی — نوبت اول: ۲۰۰ mg پنج بار در روز، ۱۰ روز","Genital herpes — first episode: 200 mg five times daily, 10 days",{"minAge":152},{"value":130,"unit":84},{"perDose":27,"dosesPerDay":29},[155],{"source":45,"section":92},{"min":136,"max":136},[36,47,55],[159],{"text":160,"refs":161},{"fa":141,"en":142},[162],{"source":45,"section":92},{"id":164,"disease":147,"label":165,"population":168,"type":115,"unit":28,"dose":170,"refs":171,"durationDays":173,"allowedFormulations":174,"notes":175},"gh-episodic",{"fa":166,"en":167},"تبخال تناسلی — عود (درمان متناوب): ۲۰۰ mg پنج بار در روز، ۵ روز","Genital herpes — recurrence (intermittent): 200 mg five times daily, 5 days",{"minAge":169},{"value":130,"unit":84},{"perDose":27,"dosesPerDay":29},[172],{"source":45,"section":92},{"min":29,"max":29},[36,47,55],[176,182],{"text":177,"refs":180},{"fa":178,"en":179},"در اولین علامت (پرودروم) شروع شود.","Start at the earliest sign or symptom (prodrome).",[181],{"source":45,"section":92},{"text":183,"refs":184},{"fa":141,"en":142},[185],{"source":45,"section":92},{"id":187,"disease":147,"label":188,"population":191,"type":115,"unit":28,"dose":193,"refs":194,"allowedFormulations":196,"notes":197},"gh-suppress",{"fa":189,"en":190},"تبخال تناسلی — سرکوب مزمن: ۴۰۰ mg دو بار در روز تا ۱۲ ماه","Genital herpes — chronic suppression: 400 mg twice daily for up to 12 months",{"minAge":192},{"value":130,"unit":84},{"perDose":40,"dosesPerDay":83},[195],{"source":45,"section":92},[36,47,55],[198,204],{"text":199,"refs":202},{"fa":200,"en":201},"پس از ۱ سال ارزیابی مجدد. رژیم‌های جایگزین: ۲۰۰ mg سه تا پنج بار در روز.","Re-evaluate after 1 year. Alternatives: 200 mg three to five times daily.",[203],{"source":45,"section":92},{"text":205,"refs":206},{"fa":141,"en":142},[207],{"source":45,"section":92},{"id":209,"disease":210,"label":211,"population":214,"type":86,"unit":28,"dose":217,"refs":219,"limits":222,"durationDays":225,"allowedFormulations":226,"notes":227},"iv-hse-adult","hsv-encephalitis",{"fa":212,"en":213},"آنسفالیت هرپسی — ۱۲ سال به بالا: ۱۰ mg\u002Fkg وریدی هر ۸ ساعت، ۱۰ روز","HSV encephalitis — ≥12 y: 10 mg\u002Fkg IV every 8 h, 10 days",{"minAge":215},{"value":216,"unit":84},12,{"perKgPerDose":136,"intervalHours":218},8,[220],{"source":73,"section":221},"Dosage",{"maxPerKgPerDose":88,"refs":223},[224],{"source":73,"section":92},{"min":136,"max":136},[64],[228],{"text":229,"refs":232},{"fa":230,"en":231},"انفوزیون یکنواخت در ۱ ساعت؛ هرگز بولوس، عضلانی یا زیرجلدی. حداکثر معادل ۲۰ mg\u002Fkg هر ۸ ساعت. چاقی: بر اساس وزن ایده‌آل. حجم نمایش‌داده‌شده از محلول غلیظ ۵۰ mg\u002FmL است و پیش از انفوزیون رقیق شود.","Infuse at a constant rate over 1 h; never bolus, IM or SC. Max equivalent of 20 mg\u002Fkg every 8 h. Obese patients: ideal body weight. The volume shown is of the 50 mg\u002FmL concentrate, which must be diluted before infusion.",[233,234],{"source":73,"section":92},{"source":73,"section":221},{"id":236,"disease":210,"label":237,"population":240,"type":86,"unit":28,"dose":245,"refs":246,"limits":248,"durationDays":251,"allowedFormulations":252,"notes":253},"iv-hse-child",{"fa":238,"en":239},"آنسفالیت هرپسی — ۳ ماه تا ۱۲ سال: ۲۰ mg\u002Fkg وریدی هر ۸ ساعت، ۱۰ روز","HSV encephalitis — 3 months to 12 y: 20 mg\u002Fkg IV every 8 h, 10 days",{"minAge":241,"maxAge":244},{"value":242,"unit":243},3,"month",{"value":216,"unit":84},{"perKgPerDose":88,"intervalHours":218},[247],{"source":73,"section":221},{"maxPerKgPerDose":88,"refs":249},[250],{"source":73,"section":92},{"min":136,"max":136},[64],[254],{"text":255,"refs":256},{"fa":230,"en":231},[257,258],{"source":73,"section":92},{"source":73,"section":221},{"id":260,"disease":210,"label":261,"population":264,"type":86,"unit":28,"dose":266,"refs":267,"limits":269,"durationDays":272,"allowedFormulations":273,"notes":274},"iv-neonatal",{"fa":262,"en":263},"هرپس نوزادی — تولد تا ۳ ماه: ۱۰ mg\u002Fkg وریدی هر ۸ ساعت، ۱۰ روز","Neonatal HSV — birth to 3 months: 10 mg\u002Fkg IV every 8 h, 10 days",{"maxAge":265},{"value":242,"unit":243},{"perKgPerDose":136,"intervalHours":218},[268],{"source":73,"section":221},{"maxPerKgPerDose":88,"refs":270},[271],{"source":73,"section":92},{"min":136,"max":136},[64],[275],{"text":276,"refs":277},{"fa":230,"en":231},[278,279],{"source":73,"section":92},{"source":73,"section":221},{"id":281,"disease":124,"label":282,"population":285,"type":86,"unit":28,"dose":287,"refs":288,"limits":290,"durationDays":293,"allowedFormulations":294,"notes":295},"iv-zoster-adult",{"fa":283,"en":284},"زونا در نقص ایمنی — ۱۲ سال به بالا: ۱۰ mg\u002Fkg وریدی هر ۸ ساعت، ۷ روز","Zoster in immunocompromised — ≥12 y: 10 mg\u002Fkg IV every 8 h, 7 days",{"minAge":286},{"value":216,"unit":84},{"perKgPerDose":136,"intervalHours":218},[289],{"source":73,"section":221},{"maxPerKgPerDose":88,"refs":291},[292],{"source":73,"section":92},{"min":135,"max":135},[64],[296],{"text":297,"refs":298},{"fa":230,"en":231},[299,300],{"source":73,"section":92},{"source":73,"section":221},{"id":302,"disease":124,"label":303,"population":306,"type":86,"unit":28,"dose":308,"refs":309,"limits":311,"durationDays":314,"allowedFormulations":315,"notes":316},"iv-zoster-child",{"fa":304,"en":305},"زونا در نقص ایمنی — زیر ۱۲ سال: ۲۰ mg\u002Fkg وریدی هر ۸ ساعت، ۷ روز","Zoster in immunocompromised — \u003C12 y: 20 mg\u002Fkg IV every 8 h, 7 days",{"maxAge":307},{"value":216,"unit":84},{"perKgPerDose":88,"intervalHours":218},[310],{"source":73,"section":221},{"maxPerKgPerDose":88,"refs":312},[313],{"source":73,"section":92},{"min":135,"max":135},[64],[317],{"text":318,"refs":319},{"fa":230,"en":231},[320,321],{"source":73,"section":92},{"source":73,"section":221},[323,332],{"id":324,"severity":325,"text":326,"refs":329},"hypersensitivity","block",{"fa":327,"en":328},"حساسیت بالینی مهم به آسیکلوویر یا والاسیکلوویر.","Clinically significant hypersensitivity to acyclovir or valacyclovir.",[330],{"source":33,"section":331},"Contraindications",{"id":333,"severity":325,"text":334,"refs":337},"under-2",{"fa":335,"en":336},"بی‌خطری اشکال خوراکی زیر ۲ سال ثابت نشده است.","Oral forms not established under 2 years.",[338],{"source":33,"section":339},"Pediatric Use",[],[342],{"egfrBelow":343,"severity":344,"text":345,"refs":348},25,"warn",{"fa":346,"en":347},"در نارسایی کلیه دوز طبق جدول برچسب تنظیم شود.","Adjust dose in renal impairment per label table.",[349],{"source":33,"section":92},[],[],{"status":353,"reviewer":354,"date":354},"unverified",null,[356,359,362,367,371,374,379,382,385,388,394,397],{"regimen":76,"formulation":22,"input":357,"expect":358},{"ageYears":29,"weightKg":88},{"perDose":40,"mlPerDose":136},{"regimen":76,"formulation":22,"input":360,"expect":361},{"ageYears":216,"weightKg":85},{"perDose":50},{"regimen":109,"formulation":22,"input":363,"expect":366},{"ageYears":364,"weightKg":365},30,70,{"perDose":50,"mlPerDose":88},{"regimen":123,"formulation":47,"input":368,"expect":370},{"ageYears":369,"weightKg":365},60,{"perDose":50,"tabletsPerDoseRounded":5},{"regimen":146,"formulation":55,"input":372,"expect":373},{"ageYears":343,"weightKg":369},{"perDose":27,"tabletsPerDoseRounded":5},{"regimen":209,"formulation":64,"input":375,"expect":376},{"ageYears":85,"weightKg":365},{"perDose":377,"mlPerDose":378},700,14,{"regimen":236,"formulation":64,"input":380,"expect":381},{"ageYears":89,"weightKg":88},{"perDose":40,"mlPerDose":218},{"regimen":164,"formulation":55,"input":383,"expect":384},{"ageYears":343,"weightKg":369},{"perDose":27,"dosesPerDay":29},{"regimen":187,"formulation":36,"input":386,"expect":387},{"ageYears":343,"weightKg":369},{"perDose":40,"dosesPerDay":83},{"regimen":260,"formulation":64,"input":389,"expect":391},{"ageDays":136,"weightKg":390},3.5,{"perDose":392,"mlPerDose":393},35,0.7,{"regimen":281,"formulation":64,"input":395,"expect":396},{"ageYears":85,"weightKg":365},{"perDose":377,"mlPerDose":378},{"regimen":302,"formulation":64,"input":398,"expect":399},{"ageYears":89,"weightKg":88},{"perDose":40,"mlPerDose":218},[401],"J05AB01",{"status":403,"forms":404,"refs":449},"registered",[405,409,413,417,421,425,429,433,437,441,445],{"code":406,"en":407,"fa":408},"00020","ACICLOVIR 3% 3G OINT OPH","پماد چشمی آسیکلوویر ۳ درصد ۳ گرم",{"code":410,"en":411,"fa":412},"00023","ACICLOVIR 400MG TAB","قرص آسیکلوویر ۴۰۰ میلی‌گرم",{"code":414,"en":415,"fa":416},"00024","ACICLOVIR 5% 10G CREAM","کرم آسیکلوویر ۵ درصد ۱۰ گرم",{"code":418,"en":419,"fa":420},"12401","ACICLOVIR 800MG TAB","قرص آسیکلوویر ۸۰۰ میلی‌گرم",{"code":422,"en":423,"fa":424},"00022","ACICLOVIR SODIUM 250MG VIAL","ویال آسیکلوویر سدیم ۲۵۰ میلی‌گرم",{"code":426,"en":427,"fa":428},"02366","ACICLOVIR SODIUM 500MG VIAL","ویال آسیکلوویر سدیم ۵۰۰ میلی‌گرم",{"code":430,"en":431,"fa":432},"05981","IMMUNOVIR 500MG TAB","قرص ایممونوویر ۵۰۰ میلی‌گرم",{"code":434,"en":435,"fa":436},"00021","ACICLOVIR 200MG TAB","قرص آسیکلوویر ۲۰۰ میلی‌گرم",{"code":438,"en":439,"fa":440},"53200","ACICLOVIR 200 mg\u002F5mL 120 ML SUSPENSION","آسیکلوویر ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",{"code":442,"en":443,"fa":444},"52881","ACICLOVIR CREAM TOPICAL 5 % 15 g","کرم آسیکلوویر ۵ درصد ۱۵ گرم",{"code":446,"en":447,"fa":448},"53098","ACICLOVIR SUSPENSION ORAL 200 mg\u002F5mL 120 mL","سوسپانسیون خوراکی آسیکلوویر ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۱۲۰ میلی‌لیتر",[450],{"source":451,"section":452,"url":453},"darooyab-generic","G-1159\u002FAciclovir","https:\u002F\u002Fwww.darooyab.ir\u002FG-1159\u002FAciclovir",[455,459,463,466,469,472,475,478,481],{"kind":456,"url":457,"label":458},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=203701","ANDA203701",{"kind":460,"url":461,"label":462},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=d3ab226c-677d-4cb7-85cb-1c2e5012f40d","FDA Acyclovir injection",{"kind":460,"url":464,"label":465},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=8208711c-18ba-4615-b932-3c0bb7e6efae","FDA Acyclovir susp",{"kind":460,"url":467,"label":468},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=0de2f5c7-9e75-4bdf-9c28-e026cc6694b4","FDA Acyclovir tablets",{"kind":460,"url":470,"label":471},"https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=85332671-0e3a-4445-a337-e1266886b9cf","FDA Acyclovir capsules",{"kind":473,"url":474,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa681045.html",{"kind":473,"url":476,"label":477},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa619042.html","Acyclovir Buccal",{"kind":479,"url":480,"label":401},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J05AB01",{"kind":482,"url":453,"label":483},"darooyab","Aciclovir",{"pregnancy":485,"lactation":494,"pediatric":502,"geriatric":509},{"level":486,"text":487,"quote":490,"refs":491},"caution",{"fa":488,"en":489},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Teratogenic Effects Pregnancy Category B Acyclovir administered during organogenesis was not teratogenic in the mouse (450 mg\u002Fkg\u002Fday, PO), rabbit (50 mg\u002Fkg\u002Fday, SC and IV), or rat (50 mg\u002Fkg\u002Fday, SC).",[492],{"source":73,"section":493},"Pregnancy",{"level":486,"text":495,"quote":498,"refs":499},{"fa":496,"en":497},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Acyclovir concentrations have been documented in breast milk in two women following oral administration of acyclovir and ranged from 0.6 to 4.1 times corresponding plasma levels.",[500],{"source":73,"section":501},"Nursing Mothers",{"level":486,"text":503,"quote":506,"refs":507},{"fa":504,"en":505},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","See DOSAGE AND ADMINISTRATION .",[508],{"source":73,"section":339},{"level":486,"text":510,"quote":513,"refs":514},{"fa":511,"en":512},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, reflecting the greater frequency of decreased renal function, and of concomitant disease or other drug therapy.",[515],{"source":73,"section":516},"Geriatric Use",{"kind":518,"refs":519,"id":458},"ANDA",[520],{"source":73,"section":521},"SPL approval \u002F marketing category",1792191874519]