[{"data":1,"prerenderedAt":244},["ShallowReactive",2],{"drug-alendronate":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":124,"warnings":134,"renal":135,"monitoring":136,"interactions":137,"review":138,"examples":141,"atc":160,"iran":162,"links":186,"populations":203,"usApproval":239},"alendronate",1,{"fa":7,"en":8},"آلندرونات","Alendronate","musculoskeletal",{"fa":11,"en":12},"بیس‌فسفونات","Bisphosphonate",[14],{"name":15,"market":16},"Fosamax","US",[18,19,7,20],"fosamax","فوزامکس","پوکی استخوان",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-10","tablet","oral","10 mg tablet",{"amount":28,"unit":29,"perUnit":24,"scored":30},10,"mg",false,[16],[33],{"source":34,"section":35},"fda-alendronate","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-35","35 mg tablet",{"amount":40,"unit":29,"perUnit":24,"scored":30},35,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-70","70 mg tablet",{"amount":48,"unit":29,"perUnit":24,"scored":30},70,[16],[51],{"source":34,"section":35},[53,78,90,109],{"id":54,"disease":55,"label":56,"population":59,"type":63,"unit":29,"dose":64,"refs":65,"durationDays":68,"notes":69},"tx-weekly","osteoporosis",{"fa":57,"en":58},"درمان پوکی استخوان — ۷۰ mg هفته‌ای یک بار","Osteoporosis treatment — 70 mg once weekly",{"minAge":60},{"value":61,"unit":62},18,"year","fixed",{"perDose":48,"dosesPerDay":5},[66],{"source":34,"section":67},"2.1",{"min":5,"max":5},[70],{"text":71,"refs":74},{"fa":72,"en":73},"هفته‌ای یک بار (یا ۱۰ mg روزانه). صبح ناشتا با یک لیوان کامل آب؛ تا ۳۰ دقیقه دراز نکشد و چیزی نخورد.","Once weekly (or 10 mg daily). Morning, fasting, full glass of water; stay upright and do not eat for 30 min.",[75,76],{"source":34,"section":67},{"source":34,"section":77},"2",{"id":79,"disease":55,"label":80,"population":83,"type":63,"unit":29,"dose":85,"refs":86,"durationDays":89},"prev",{"fa":81,"en":82},"پیشگیری پوکی استخوان یائسگی — ۳۵ mg هفته‌ای (یا ۵ mg روزانه)","Postmenopausal prevention — 35 mg weekly (or 5 mg daily)",{"minAge":84},{"value":61,"unit":62},{"perDose":40,"dosesPerDay":5},[87],{"source":34,"section":88},"2.2",{"min":5,"max":5},{"id":91,"disease":55,"label":92,"population":95,"type":63,"unit":29,"dose":97,"refs":99,"notes":102},"steroid",{"fa":93,"en":94},"پوکی استخوان ناشی از کورتون — ۵ mg روزانه","Glucocorticoid-induced osteoporosis — 5 mg daily",{"minAge":96},{"value":61,"unit":62},{"perDose":98,"dosesPerDay":5},5,[100],{"source":34,"section":101},"2.4",[103],{"text":104,"refs":107},{"fa":105,"en":106},"زنان یائسه بدون استروژن: ۱۰ mg روزانه.","Postmenopausal women not on oestrogen: 10 mg daily.",[108],{"source":34,"section":101},{"id":110,"disease":111,"label":112,"population":115,"type":63,"unit":29,"dose":117,"refs":119,"durationDays":122},"paget","pagets-disease",{"fa":113,"en":114},"پاژه — ۴۰ mg روزانه به مدت ۶ ماه","Paget's disease — 40 mg daily for 6 months",{"minAge":116},{"value":61,"unit":62},{"perDose":118,"dosesPerDay":5},40,[120],{"source":34,"section":121},"2.5",{"min":123,"max":123},180,[125],{"id":126,"severity":127,"text":128,"refs":131},"ci","block",{"fa":129,"en":130},"اختلال مری که تخلیه را کند می‌کند (تنگی، آشالازی)؛ ناتوانی در ایستادن یا نشستن ۳۰ دقیقه؛ هیپوکلسمی؛ حساسیت.","Oesophageal abnormalities delaying emptying (stricture, achalasia); inability to stand or sit upright for 30 min; hypocalcaemia; hypersensitivity.",[132],{"source":34,"section":133},"4",[],[],[],[],{"status":139,"reviewer":140,"date":140},"unverified",null,[142,147,151,156],{"regimen":54,"formulation":45,"input":143,"expect":146},{"ageYears":144,"weightKg":145},65,60,{"perDose":48},{"regimen":79,"formulation":37,"input":148,"expect":150},{"ageYears":149,"weightKg":145},55,{"perDose":40},{"regimen":91,"formulation":23,"input":152,"expect":154},{"ageYears":153,"weightKg":48},50,{"status":155},"blocked",{"regimen":110,"formulation":23,"input":157,"expect":158},{"ageYears":48,"weightKg":48},{"perDose":118,"tabletsPerDoseRounded":159},4,[161],"M05BA04",{"status":163,"forms":164,"refs":181},"registered",[165,169,173,177],{"code":166,"en":167,"fa":168},"01842","ALENDRONATE SODIUM 10MG TAB","قرص آلندرونات سدیم ۱۰ میلی‌گرم",{"code":170,"en":171,"fa":172},"02405","ALENDRONATE SODIUM 35MG TAB","قرص آلندرونات سدیم ۳۵ میلی‌گرم",{"code":174,"en":175,"fa":176},"02406","ALENDRONATE SODIUM 70MG TAB","قرص آلندرونات سدیم ۷۰ میلی‌گرم",{"code":178,"en":179,"fa":180},"53192","ALENDRONATE SODIUM 70MG EFF TAB","قرص جوشان آلندرونات سدیم ۷۰ میلی‌گرم",[182],{"source":183,"section":184,"url":185},"darooyab-generic","G-1427\u002FAlendronate","https:\u002F\u002Fwww.darooyab.ir\u002FG-1427\u002FAlendronate",[187,191,195,198,201],{"kind":188,"url":189,"label":190},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=090124","ANDA090124",{"kind":192,"url":193,"label":194},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4323d3aa-cbb0-41e2-aba7-7a94a0516993","FDA Alendronate",{"kind":196,"url":197,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601011.html",{"kind":199,"url":200,"label":161},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M05BA04",{"kind":202,"url":185,"label":8},"darooyab",{"pregnancy":204,"lactation":213,"pediatric":222,"geriatric":231},{"level":205,"text":206,"quote":209,"refs":210},"avoid",{"fa":207,"en":208},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Discontinue alendronate sodium when pregnancy is recognized.",[211],{"source":34,"section":212},"8.1",{"level":214,"text":215,"quote":218,"refs":219},"caution",{"fa":216,"en":217},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for alendronate sodium and any potential adverse effects on the breastfed child from alendronate sodium or from the underlying maternal condition.",[220],{"source":34,"section":221},"8.2",{"level":223,"text":224,"quote":227,"refs":228},"not-established",{"fa":225,"en":226},"برچسب: ایمنی و اثربخشی در کودکان ثابت نشده است.","Label: safety and effectiveness in children have not been established.","Alendronate sodium is not indicated for use in pediatric patients.",[229],{"source":34,"section":230},"8.4",{"level":214,"text":232,"quote":235,"refs":236},{"fa":233,"en":234},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Of the patients receiving alendronate sodium in the Fracture Intervention Trial (FIT), 71% (n=2302) were greater than or equal to 65 years of age and 17% (n=550) were greater than or equal to 75 years of age.",[237],{"source":34,"section":238},"8.5",{"kind":240,"refs":241,"id":190},"ANDA",[242],{"source":34,"section":243},"SPL approval \u002F marketing category",1792191876180]