[{"data":1,"prerenderedAt":237},["ShallowReactive",2],{"drug-allopurinol":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":52,"contraindications":130,"warnings":140,"renal":141,"monitoring":142,"interactions":143,"review":144,"examples":147,"atc":167,"iran":169,"links":185,"populations":205,"usApproval":232},"allopurinol",1,{"fa":7,"en":8},"آلوپورینول","Allopurinol","musculoskeletal",{"fa":11,"en":12},"مهارکننده گزانتین اکسیداز","Xanthine oxidase inhibitor",[14],{"name":15,"market":16},"Zyloprim","US",[18,19,7,20],"zyloprim","زیلوپریم","اسید اوریک",[22,36,44],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"tab-100","tablet","oral","100 mg tablet (scored)",{"amount":28,"unit":29,"perUnit":24,"scored":30},100,"mg",true,[16],[33],{"source":34,"section":35},"fda-allopurinol","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"tab-200","200 mg tablet (scored)",{"amount":40,"unit":29,"perUnit":24,"scored":30},200,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"tab-300","300 mg tablet (scored)",{"amount":48,"unit":29,"perUnit":24,"scored":30},300,[16],[51],{"source":34,"section":35},[53,79,92,117],{"id":54,"disease":54,"label":55,"population":58,"type":62,"unit":29,"dose":63,"refs":67,"notes":70},"gout",{"fa":56,"en":57},"نقرس (کاهش اسید اوریک) — شروع ۱۰۰ mg\u002Fday، افزایش هفتگی","Gout (urate lowering) — start 100 mg\u002Fday, weekly increases",{"minAge":59},{"value":60,"unit":61},18,"year","titration",{"dividedDoses":5,"titration":64},{"start":28,"increment":28,"incrementEveryDays":65,"max":66},7,800,[68],{"source":34,"section":69},"2.3",[71],{"text":72,"refs":75},{"fa":73,"en":74},"افزایش ۱۰۰ mg هر هفته تا اسید اوریک ≤۶ mg\u002FdL؛ حداکثر ۸۰۰ mg\u002Fday. نارسایی کلیه: شروع ۵۰ mg. حمله همزمان جداگانه درمان شود.","Increase by 100 mg weekly until uric acid ≤6 mg\u002FdL; max 800 mg\u002Fday. Renal impairment: start 50 mg. Treat flares alongside.",[76,77],{"source":34,"section":69},{"source":34,"section":78},"2",{"id":80,"disease":81,"label":82,"population":85,"type":87,"unit":29,"dose":88,"refs":89},"stones","calcium-oxalate-stones",{"fa":83,"en":84},"سنگ کلسیم اگزالات عودکننده — ۲۰۰ تا ۳۰۰ mg\u002Fday","Recurrent calcium oxalate stones — 200–300 mg\u002Fday",{"minAge":86},{"value":60,"unit":61},"fixed",{"perDose":40,"perDoseMax":48,"dosesPerDay":5},[90],{"source":34,"section":91},"2.5",{"id":93,"disease":94,"label":95,"population":98,"type":100,"unit":29,"dose":101,"refs":104,"limits":107,"notes":110},"tls-child","cancer-hyperuricemia",{"fa":96,"en":97},"اسید اوریک در درمان سرطان — کودک: ۱۰ mg\u002Fkg\u002Fروز در ۲ تا ۳ دوز","Hyperuricaemia with cancer therapy — child: 10 mg\u002Fkg\u002Fday in 2–3 doses",{"maxAge":99},{"value":60,"unit":61},"weightBased",{"perKgPerDay":102,"dividedDoses":103},10,2,[105],{"source":34,"section":106},"2.4",{"maxPerDay":66,"refs":108},[109],{"source":34,"section":106},[111],{"text":112,"refs":115},{"fa":113,"en":114},"برچسب: ۱۰۰ mg\u002Fm² هر ۸ تا ۱۲ ساعت (۱۰ mg\u002Fkg\u002Fروز، حداکثر ۸۰۰ mg).","Label: 100 mg\u002Fm² every 8–12 h (10 mg\u002Fkg\u002Fday, max 800 mg\u002Fday).",[116],{"source":34,"section":106},{"id":118,"disease":94,"label":119,"population":122,"type":87,"unit":29,"dose":124,"refs":125,"limits":127},"tls-adult",{"fa":120,"en":121},"اسید اوریک در درمان سرطان — بزرگسال: ۳۰۰ تا ۸۰۰ mg روزانه","Hyperuricaemia with cancer therapy — adult: 300–800 mg daily",{"minAge":123},{"value":60,"unit":61},{"perDose":48,"dosesPerDay":5},[126],{"source":34,"section":106},{"maxPerDay":66,"refs":128},[129],{"source":34,"section":106},[131],{"id":132,"severity":133,"text":134,"refs":137},"ci","block",{"fa":135,"en":136},"سابقه واکنش حساسیتی به آلوپورینول.","History of hypersensitivity reaction to allopurinol.",[138],{"source":34,"section":139},"4",[],[],[],[],{"status":145,"reviewer":146,"date":146},"unverified",null,[148,153,158,163],{"regimen":54,"formulation":23,"input":149,"expect":152},{"ageYears":150,"weightKg":151},50,85,{"perDose":28},{"regimen":80,"formulation":37,"input":154,"expect":157},{"ageYears":155,"weightKg":156},45,80,{"perDose":40,"upperPerDose":48},{"regimen":93,"formulation":23,"input":159,"expect":162},{"ageYears":160,"weightKg":161},6,20,{"perDose":28,"tabletsPerDoseRounded":5},{"regimen":118,"formulation":45,"input":164,"expect":166},{"ageYears":150,"weightKg":165},70,{"perDose":48},[168],"M04AA01",{"status":170,"forms":171,"refs":180},"registered",[172,176],{"code":173,"en":174,"fa":175},"00038","ALLOPURINOL 100MG TAB","قرص آلوپورینول ۱۰۰ میلی‌گرم",{"code":177,"en":178,"fa":179},"02017","ALLOPURINOL 300MG TAB","قرص آلوپورینول ۳۰۰ میلی‌گرم",[181],{"source":182,"section":183,"url":184},"darooyab-generic","G-754\u002FAllopurinol","https:\u002F\u002Fwww.darooyab.ir\u002FG-754\u002FAllopurinol",[186,190,194,197,200,203],{"kind":187,"url":188,"label":189},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=204467","ANDA204467",{"kind":191,"url":192,"label":193},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=71fd88d2-cfd8-4abd-bb15-7ef2699ccf9d","FDA Allopurinol",{"kind":195,"url":196,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682673.html",{"kind":195,"url":198,"label":199},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa622045.html","Allopurinol Injection",{"kind":201,"url":202,"label":168},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=M04AA01",{"kind":204,"url":184,"label":8},"darooyab",{"pregnancy":206,"lactation":215,"pediatric":223},{"level":207,"text":208,"quote":211,"refs":212},"avoid",{"fa":209,"en":210},"برچسب: می‌تواند به جنین آسیب بزند. در بارداری خطرناک است.","Label: can cause fetal harm. Dangerous in pregnancy.","Risk Summary Based on findings in animals, allopurinol tablets may cause fetal harm when administered to a pregnant woman.",[213],{"source":34,"section":214},"8.1",{"level":207,"text":216,"quote":219,"refs":220},{"fa":217,"en":218},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in a breastfed child, advise women not to breastfeed during treatments with allopurinol tablets and for one week after the last dose.",[221],{"source":34,"section":222},"8.2",{"level":224,"text":225,"quote":228,"refs":229},"caution",{"fa":226,"en":227},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","Hyperuricemia Associated with Cancer Therapy The safety and effectiveness of allopurinol for the management of pediatric patients with leukemia, lymphoma and solid tumor malignancies who are receiving cancer therapy which causes elevations of serum and urinary uric acid levels have been established in approximately …",[230],{"source":34,"section":231},"8.4",{"kind":233,"refs":234,"id":189},"ANDA",[235],{"source":34,"section":236},"SPL approval \u002F marketing category",1792191876124]