[{"data":1,"prerenderedAt":271},["ShallowReactive",2],{"drug-amitriptyline":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":23,"regimens":78,"contraindications":138,"warnings":159,"renal":160,"monitoring":161,"interactions":162,"review":163,"examples":166,"atc":177,"iran":179,"links":215,"populations":232,"usApproval":266},"amitriptyline",1,{"fa":7,"en":8},"آمی‌تریپتیلین","Amitriptyline","nervous-system",{"fa":11,"en":12},"ضدافسردگی سه‌حلقه‌ای","Tricyclic antidepressant",[14],{"name":15,"market":16},"Elavil","US",[18,19,20,21,22],"elavil","آمی تریپتیلین","امی تریپتیلین","آمیتریپتیلین","TCA",[24,38,46,54,62,70],{"id":25,"form":26,"route":27,"label":28,"concentration":29,"markets":33,"refs":34},"tab-10","tablet","oral","10 mg tablet",{"amount":30,"unit":31,"perUnit":26,"scored":32},10,"mg",false,[16],[35],{"source":36,"section":37},"fda-amitriptyline","How Supplied",{"id":39,"form":26,"route":27,"label":40,"concentration":41,"markets":43,"refs":44},"tab-25","25 mg tablet",{"amount":42,"unit":31,"perUnit":26,"scored":32},25,[16],[45],{"source":36,"section":37},{"id":47,"form":26,"route":27,"label":48,"concentration":49,"markets":51,"refs":52},"tab-50","50 mg tablet",{"amount":50,"unit":31,"perUnit":26,"scored":32},50,[16],[53],{"source":36,"section":37},{"id":55,"form":26,"route":27,"label":56,"concentration":57,"markets":59,"refs":60},"tab-75","75 mg tablet",{"amount":58,"unit":31,"perUnit":26,"scored":32},75,[16],[61],{"source":36,"section":37},{"id":63,"form":26,"route":27,"label":64,"concentration":65,"markets":67,"refs":68},"tab-100","100 mg tablet",{"amount":66,"unit":31,"perUnit":26,"scored":32},100,[16],[69],{"source":36,"section":37},{"id":71,"form":26,"route":27,"label":72,"concentration":73,"markets":75,"refs":76},"tab-150","150 mg tablet",{"amount":74,"unit":31,"perUnit":26,"scored":32},150,[16],[77],{"source":36,"section":37},[79,105,123],{"id":80,"disease":81,"label":82,"population":85,"type":89,"unit":31,"dose":90,"refs":92,"limits":95,"notes":98},"adult","mdd",{"fa":83,"en":84},"افسردگی — بزرگسال سرپایی: ۷۵ mg\u002Fday منقسم","Depression — adult outpatients: 75 mg\u002Fday divided",{"minAge":86},{"value":87,"unit":88},18,"year","fixed",{"perDose":42,"dosesPerDay":91},3,[93],{"source":36,"section":94},"Dosage and Administration",{"maxPerDay":74,"refs":96},[97],{"source":36,"section":94},[99],{"text":100,"refs":103},{"fa":101,"en":102},"در صورت نیاز تا ۱۵۰ mg\u002Fday. روش دیگر: ۵۰ تا ۱۰۰ mg شب و افزایش ۲۵ تا ۵۰ mg تا ۱۵۰. بستری‌ها تا ۲۰۰ (به‌ندرت ۳۰۰) mg\u002Fday.","If needed up to 150 mg\u002Fday. Alternative: 50–100 mg at bedtime, increasing by 25–50 mg to 150. Inpatients up to 200 (rarely 300) mg\u002Fday.",[104],{"source":36,"section":94},{"id":106,"disease":81,"label":107,"population":110,"type":89,"unit":31,"dose":113,"refs":114,"notes":116},"adolescent",{"fa":108,"en":109},"افسردگی — نوجوان و سالمند: ۱۰ mg سه بار + ۲۰ mg شب","Depression — adolescents and elderly: 10 mg three times daily + 20 mg at bedtime",{"minAge":111},{"value":112,"unit":88},12,{"perDose":30,"dosesPerDay":91},[115],{"source":36,"section":94},[117],{"text":118,"refs":121},{"fa":119,"en":120},"به‌اضافه ۲۰ mg هنگام خواب (جمعاً ۵۰ mg\u002Fday) در کسانی که دوز بالاتر را تحمل نمی‌کنند.","Plus 20 mg at bedtime (total 50 mg\u002Fday) for patients who do not tolerate higher doses.",[122],{"source":36,"section":94},{"id":124,"disease":81,"label":125,"population":128,"type":130,"unit":31,"dose":131,"refs":135},"peds",{"fa":126,"en":127},"زیر ۱۲ سال","Under 12 years",{"maxAge":129},{"value":112,"unit":88},"notCalculated",{"reason":132},{"fa":133,"en":134},"بی‌خطری و اثربخشی در کودکان ثابت نشده.","Safety and effectiveness in children not established.",[136],{"source":36,"section":137},"Pediatric Use",[139,148],{"id":140,"severity":141,"text":142,"refs":145},"ci","block",{"fa":143,"en":144},"حساسیت؛ همراه یا تا ۱۴ روز پس از MAOI.","Hypersensitivity; with or within 14 days of an MAOI.",[146],{"source":36,"section":147},"Contraindications",{"id":149,"severity":150,"rule":151,"text":153,"refs":156},"suicide","warn",{"maxAge":152},{"value":42,"unit":88},{"fa":154,"en":155},"هشدار جعبه‌ای: افزایش افکار و رفتار خودکشی در کودکان، نوجوانان و جوانان.","Boxed warning: increased suicidal thoughts and behaviour in children, adolescents and young adults.",[157],{"source":36,"section":158},"Boxed Warning",[],[],[],[],{"status":164,"reviewer":165,"date":165},"unverified",null,[167,172],{"regimen":80,"formulation":39,"input":168,"expect":171},{"ageYears":169,"weightKg":170},35,70,{"perDose":42,"perDay":58},{"regimen":106,"formulation":25,"input":173,"expect":176},{"ageYears":174,"weightKg":175},15,55,{"perDose":30},[178],"N06AA09",{"status":180,"forms":181,"refs":210},"registered",[182,186,190,194,198,202,206],{"code":183,"en":184,"fa":185},"00066","AMITRIPTYLINE 100MG TAB","قرص آمی‌تریپتیلین ۱۰۰ میلی‌گرم",{"code":187,"en":188,"fa":189},"00065","AMITRIPTYLINE 10MG TAB","قرص آمی‌تریپتیلین ۱۰ میلی‌گرم",{"code":191,"en":192,"fa":193},"00067","AMITRIPTYLINE 10MG\u002FML VIAL","ویال آمی‌تریپتیلین ۱۰ میلی‌گرم \u002F میلی‌لیتر",{"code":195,"en":196,"fa":197},"00068","AMITRIPTYLINE 25MG TAB","قرص آمی‌تریپتیلین ۲۵ میلی‌گرم",{"code":199,"en":200,"fa":201},"00069","AMITRIPTYLINE 50MG TAB","قرص آمی‌تریپتیلین ۵۰ میلی‌گرم",{"code":203,"en":204,"fa":205},"12119","AMITRIPTYLINE 50MG\u002F2ML AMP","آمپول آمی‌تریپتیلین ۵۰ میلی‌گرم \u002F ۲ میلی‌لیتر",{"code":207,"en":208,"fa":209},"07135","AMITRIPTYLINE 75MG TAB","قرص آمی‌تریپتیلین ۷۵ میلی‌گرم",[211],{"source":212,"section":213,"url":214},"darooyab-generic","G-569\u002FAmitriptyline","https:\u002F\u002Fwww.darooyab.ir\u002FG-569\u002FAmitriptyline",[216,220,224,227,230],{"kind":217,"url":218,"label":219},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=089399","ANDA089399",{"kind":221,"url":222,"label":223},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=4e520c63-1cf6-40f6-a51c-3f9b0e181342","FDA Amitriptyline",{"kind":225,"url":226,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa682388.html",{"kind":228,"url":229,"label":178},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=N06AA09",{"kind":231,"url":214,"label":8},"darooyab",{"pregnancy":233,"lactation":242,"pediatric":251,"geriatric":258},{"level":234,"text":235,"quote":238,"refs":239},"caution",{"fa":236,"en":237},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Amitriptyline hydrochloride should be used during pregnancy only if the potential benefit to the mother justifies the potential risk to the fetus.",[240],{"source":36,"section":241},"Precautions\u002FWarnings – Usage in Pregnancy",{"level":243,"text":244,"quote":247,"refs":248},"avoid",{"fa":245,"en":246},"برچسب: شیردهی توصیه نمی‌شود یا باید بین دارو و شیردهی یکی انتخاب شود.","Label: breastfeeding not recommended, or choose between the drug and breastfeeding.","Because of the potential for serious adverse reactions in nursing infants from amitriptyline, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother.",[249],{"source":36,"section":250},"Nursing Mothers",{"level":243,"text":252,"quote":255,"refs":256},{"fa":253,"en":254},"هشدار جعبه‌ای برچسب درباره کودکان.","Boxed warning in the label about children.","Amitriptyline hydrochloride is not approved for use in pediatric patients.",[257],{"source":36,"section":158},{"level":234,"text":259,"quote":262,"refs":263},{"fa":260,"en":261},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic function, concomitant disease and other drug therapy in elderly patients.",[264],{"source":36,"section":265},"Geriatric Use",{"kind":267,"refs":268,"id":219},"ANDA",[269],{"source":36,"section":270},"SPL approval \u002F marketing category",1792440739678]