[{"data":1,"prerenderedAt":578},["ShallowReactive",2],{"drug-amoxicillin":3},{"id":4,"schemaVersion":5,"name":6,"category":9,"class":10,"brands":13,"synonyms":17,"formulations":21,"regimens":109,"contraindications":330,"warnings":340,"renal":376,"monitoring":386,"interactions":387,"review":388,"examples":391,"atc":449,"iran":451,"links":519,"populations":539,"usApproval":573},"amoxicillin",1,{"fa":7,"en":8},"آموکسی‌سیلین","Amoxicillin","anti-infectives",{"fa":11,"en":12},"آمینوپنی‌سیلین (بتالاکتام)","Aminopenicillin (beta-lactam)",[14],{"name":15,"market":16},"Amoxil","US",[18,19,20],"amoxycillin","آموکسی","اموکسی سیلین",[22,36,44,52,60,70,77,85,93,100],{"id":23,"form":24,"route":25,"label":26,"concentration":27,"markets":31,"refs":32},"susp-125-5","suspension","oral","125 mg \u002F 5 mL",{"amount":28,"unit":29,"perVolumeMl":30},125,"mg",5,[16],[33],{"source":34,"section":35},"fda-amoxicillin","3",{"id":37,"form":24,"route":25,"label":38,"concentration":39,"markets":41,"refs":42},"susp-200-5","200 mg \u002F 5 mL",{"amount":40,"unit":29,"perVolumeMl":30},200,[16],[43],{"source":34,"section":35},{"id":45,"form":24,"route":25,"label":46,"concentration":47,"markets":49,"refs":50},"susp-250-5","250 mg \u002F 5 mL",{"amount":48,"unit":29,"perVolumeMl":30},250,[16],[51],{"source":34,"section":35},{"id":53,"form":24,"route":25,"label":54,"concentration":55,"markets":57,"refs":58},"susp-400-5","400 mg \u002F 5 mL",{"amount":56,"unit":29,"perVolumeMl":30},400,[16],[59],{"source":34,"section":35},{"id":61,"form":62,"route":25,"label":63,"concentration":64,"markets":67,"refs":68},"chew-125","chewable-tablet","125 mg chewable",{"amount":28,"unit":29,"perUnit":65,"scored":66},"tablet",false,[16],[69],{"source":34,"section":35},{"id":71,"form":62,"route":25,"label":72,"concentration":73,"markets":74,"refs":75},"chew-250","250 mg chewable",{"amount":48,"unit":29,"perUnit":65,"scored":66},[16],[76],{"source":34,"section":35},{"id":78,"form":79,"route":25,"label":80,"concentration":81,"markets":82,"refs":83},"cap-250","capsule","250 mg capsule",{"amount":48,"unit":29,"perUnit":79,"scored":66},[16],[84],{"source":34,"section":35},{"id":86,"form":79,"route":25,"label":87,"concentration":88,"markets":90,"refs":91},"cap-500","500 mg capsule",{"amount":89,"unit":29,"perUnit":79,"scored":66},500,[16],[92],{"source":34,"section":35},{"id":94,"form":65,"route":25,"label":95,"concentration":96,"markets":97,"refs":98},"tab-500","500 mg tablet",{"amount":89,"unit":29,"perUnit":65,"scored":66},[16],[99],{"source":34,"section":35},{"id":101,"form":65,"route":25,"label":102,"concentration":103,"markets":106,"refs":107},"tab-875","875 mg tablet (scored)",{"amount":104,"unit":29,"perUnit":65,"scored":105},875,true,[16],[108],{"source":34,"section":35},[110,142,162,182,201,221,240,261,299,315],{"id":111,"disease":112,"label":113,"population":116,"type":121,"unit":29,"dose":122,"refs":125,"limits":128,"notes":134},"mild-q12","ent-skin-gu-infection",{"fa":114,"en":115},"خفیف\u002Fمتوسط — هر ۱۲ ساعت","Mild\u002Fmoderate — every 12 h",{"minAge":117,"maxWeightKg":120},{"value":118,"unit":119},3,"month",40,"weightBased",{"perKgPerDay":123,"dividedDoses":124},25,2,[126],{"source":34,"section":127},"2.2, Table 1",{"maxPerDose":89,"refs":129},[130],{"source":34,"section":127,"note":131},{"fa":132,"en":133},"دوز بزرگسال (بیماران بالای ۴۰ کیلوگرم، جدول ۱) به‌عنوان سقف هر نوبت","Adult dose for patients >40 kg (Table 1) used as per-dose ceiling",[135],{"text":136,"refs":139},{"fa":137,"en":138},"درمان تا ۴۸ تا ۷۲ ساعت پس از بی‌علامت شدن ادامه یابد؛ برای عفونت استرپتوکوک پیوژنز حداقل ۱۰ روز.","Continue 48–72 h beyond becoming asymptomatic; at least 10 days for Streptococcus pyogenes infection.",[140],{"source":34,"section":141},"2.2",{"id":143,"disease":112,"label":144,"population":147,"type":121,"unit":29,"dose":149,"refs":151,"limits":153,"notes":157},"mild-q8",{"fa":145,"en":146},"خفیف\u002Fمتوسط — هر ۸ ساعت","Mild\u002Fmoderate — every 8 h",{"minAge":148,"maxWeightKg":120},{"value":118,"unit":119},{"perKgPerDay":150,"dividedDoses":118},20,[152],{"source":34,"section":127},{"maxPerDose":48,"refs":154},[155],{"source":34,"section":127,"note":156},{"fa":132,"en":133},[158],{"text":159,"refs":160},{"fa":137,"en":138},[161],{"source":34,"section":141},{"id":163,"disease":112,"label":164,"population":167,"type":121,"unit":29,"dose":169,"refs":171,"limits":173,"notes":177},"severe-q12",{"fa":165,"en":166},"شدید — هر ۱۲ ساعت","Severe — every 12 h",{"minAge":168,"maxWeightKg":120},{"value":118,"unit":119},{"perKgPerDay":170,"dividedDoses":124},45,[172],{"source":34,"section":127},{"maxPerDose":104,"refs":174},[175],{"source":34,"section":127,"note":176},{"fa":132,"en":133},[178],{"text":179,"refs":180},{"fa":137,"en":138},[181],{"source":34,"section":141},{"id":183,"disease":112,"label":184,"population":187,"type":121,"unit":29,"dose":189,"refs":190,"limits":192,"notes":196},"severe-q8",{"fa":185,"en":186},"شدید — هر ۸ ساعت","Severe — every 8 h",{"minAge":188,"maxWeightKg":120},{"value":118,"unit":119},{"perKgPerDay":120,"dividedDoses":118},[191],{"source":34,"section":127},{"maxPerDose":89,"refs":193},[194],{"source":34,"section":127,"note":195},{"fa":132,"en":133},[197],{"text":198,"refs":199},{"fa":137,"en":138},[200],{"source":34,"section":141},{"id":202,"disease":203,"label":204,"population":207,"type":121,"unit":29,"dose":209,"refs":210,"limits":212,"notes":216},"lrti-q12","lower-respiratory-infection",{"fa":205,"en":206},"عفونت تنفسی تحتانی — هر ۱۲ ساعت","Lower respiratory tract — every 12 h",{"minAge":208,"maxWeightKg":120},{"value":118,"unit":119},{"perKgPerDay":170,"dividedDoses":124},[211],{"source":34,"section":127},{"maxPerDose":104,"refs":213},[214],{"source":34,"section":127,"note":215},{"fa":132,"en":133},[217],{"text":218,"refs":219},{"fa":137,"en":138},[220],{"source":34,"section":141},{"id":222,"disease":203,"label":223,"population":226,"type":121,"unit":29,"dose":228,"refs":229,"limits":231,"notes":235},"lrti-q8",{"fa":224,"en":225},"عفونت تنفسی تحتانی — هر ۸ ساعت","Lower respiratory tract — every 8 h",{"minAge":227,"maxWeightKg":120},{"value":118,"unit":119},{"perKgPerDay":120,"dividedDoses":118},[230],{"source":34,"section":127},{"maxPerDose":89,"refs":232},[233],{"source":34,"section":127,"note":234},{"fa":132,"en":133},[236],{"text":237,"refs":238},{"fa":137,"en":138},[239],{"source":34,"section":141},{"id":241,"disease":112,"label":242,"population":245,"type":121,"unit":29,"dose":249,"refs":251,"notes":254},"infant-under-3mo",{"fa":243,"en":244},"نوزاد و شیرخوار زیر ۳ ماه — حداکثر دوز","Neonates and infants \u003C3 months — upper dose",{"maxAge":246},{"value":247,"unit":248},12,"week",{"perKgPerDay":250,"dividedDoses":124},30,[252],{"source":34,"section":253},"2.3",[255],{"text":256,"refs":259},{"fa":257,"en":258},"به علت تکامل ناقص عملکرد کلیه، ۳۰ mg\u002Fkg\u002Fday سقف دوز این گروه سنی است.","30 mg\u002Fkg\u002Fday is the recommended upper dose in this age group because renal function is incompletely developed.",[260],{"source":34,"section":253},{"id":262,"disease":263,"label":264,"population":267,"type":121,"unit":29,"dose":270,"refs":272,"durationDays":283,"notes":285},"aom-high-dose","acute-otitis-media",{"fa":265,"en":266},"اوتیت مدیای حاد — دوز بالا، هر ۱۲ ساعت","Acute otitis media — high dose, every 12 h",{"minAge":268,"maxWeightKg":120},{"value":269,"unit":119},6,{"perKgPerDay":271,"dividedDoses":124},90,[273,279],{"source":274,"section":275,"note":276},"cps-aom-2016","Table 1",{"fa":277,"en":278},"خط اول: ۷۵ تا ۹۰ mg\u002Fkg\u002Fday در دو نوبت","First-line: 75–90 mg\u002Fkg\u002Fday divided twice daily",{"source":34,"section":127,"note":280},{"fa":281,"en":282},"بیماران بالای ۴۰ کیلوگرم: دوز بزرگسال","Patients >40 kg: adult dosing",{"min":30,"max":284},10,[286,292],{"text":287,"refs":290},{"fa":288,"en":289},"محدوده توصیه‌شده ۷۵ تا ۹۰ mg\u002Fkg\u002Fday است؛ این محاسبه حد بالای ۹۰ را نشان می‌دهد.","Recommended range is 75–90 mg\u002Fkg\u002Fday; this calculation shows the upper value of 90.",[291],{"source":274,"section":275},{"text":293,"refs":296},{"fa":294,"en":295},"مدت: زیر ۲ سال ۱۰ روز؛ ۲ سال و بالاتر بدون عارضه ۵ روز.","Duration: 10 days under 2 years; 5 days for uncomplicated disease at 2 years and older.",[297],{"source":274,"section":298},"Appropriate duration of antimicrobial therapy for AOM",{"id":300,"disease":112,"label":301,"population":304,"type":305,"unit":29,"dose":306,"refs":307,"allowedFormulations":309,"notes":310},"adult-mild",{"fa":302,"en":303},"بزرگسال و بالای ۴۰ کیلوگرم — خفیف\u002Fمتوسط ۵۰۰ mg هر ۱۲ ساعت","Adults and >40 kg — mild\u002Fmoderate 500 mg every 12 h",{"minWeightKg":120},"fixed",{"perDose":89,"dosesPerDay":124},[308],{"source":34,"section":127},[86,94,45,53],[311],{"text":312,"refs":313},{"fa":137,"en":138},[314],{"source":34,"section":141},{"id":316,"disease":112,"label":317,"population":320,"type":305,"unit":29,"dose":321,"refs":322,"allowedFormulations":324,"notes":325},"adult-severe",{"fa":318,"en":319},"بزرگسال و بالای ۴۰ کیلوگرم — شدید ۸۷۵ mg هر ۱۲ ساعت","Adults and >40 kg — severe 875 mg every 12 h",{"minWeightKg":120},{"perDose":104,"dosesPerDay":124},[323],{"source":34,"section":127},[101,53],[326],{"text":327,"refs":328},{"fa":137,"en":138},[329],{"source":34,"section":141},[331],{"id":332,"severity":333,"text":334,"refs":337},"beta-lactam-hypersensitivity","block",{"fa":335,"en":336},"سابقه واکنش حساسیتی جدی (آنافیلاکسی یا استیونس-جانسون) به آموکسی‌سیلین یا سایر بتالاکتام‌ها.","History of serious hypersensitivity (anaphylaxis or Stevens-Johnson syndrome) to amoxicillin or other beta-lactams.",[338],{"source":34,"section":339},"4",[341,348,355,362,369],{"text":342,"refs":345},{"fa":343,"en":344},"واکنش‌های آنافیلاکتیک","Anaphylactic reactions",[346],{"source":34,"section":347},"5.1",{"text":349,"refs":352},{"fa":350,"en":351},"واکنش‌های شدید پوستی","Severe cutaneous adverse reactions",[353],{"source":34,"section":354},"5.2",{"text":356,"refs":359},{"fa":357,"en":358},"سندرم انتروکولیت ناشی از دارو (DIES)","Drug-induced enterocolitis syndrome (DIES)",[360],{"source":34,"section":361},"5.3",{"text":363,"refs":366},{"fa":364,"en":365},"اسهال مرتبط با کلستریدیوئیدس دیفیسیل","Clostridioides difficile-associated diarrhea",[367],{"source":34,"section":368},"5.4",{"text":370,"refs":373},{"fa":371,"en":372},"بثورات پوستی در بیماران مبتلا به مونونوکلئوز؛ مصرف توصیه نمی‌شود.","Skin rash in patients with mononucleosis",[374],{"source":34,"section":375},"5.6",[377],{"egfrBelow":250,"severity":378,"text":379,"refs":382},"warn",{"fa":380,"en":381},"نارسایی شدید کلیه: کاهش دوز طبق جدول برچسب (بیماران بالای ۴۰ کیلوگرم). برای کودکان با نارسایی کلیه توصیه دوزی وجود ندارد.","Severe renal impairment: reduce dose per label (patients >40 kg). No dosing recommendations exist for pediatric patients with impaired renal function.",[383,385],{"source":34,"section":384},"2.5",{"source":34,"section":253},[],[],{"status":389,"reviewer":390,"date":390},"unverified",null,[392,398,403,409,414,419,424,430,436,441,446],{"regimen":111,"formulation":23,"input":393,"expect":395},{"ageYears":118,"weightKg":394},14,{"perDose":396,"mlPerDose":397,"dosesPerDay":124},175,7,{"regimen":143,"formulation":45,"input":399,"expect":400},{"ageYears":118,"weightKg":394},{"perDose":401,"mlPerDoseRounded":402},93.33,1.9,{"regimen":163,"formulation":53,"input":404,"expect":405},{"ageYears":124,"weightKg":247},{"perDose":406,"mlPerDose":407,"mlPerDoseRounded":408},270,3.38,3.4,{"regimen":183,"formulation":45,"input":410,"expect":411},{"ageYears":124,"weightKg":247},{"perDose":412,"mlPerDose":413},160,3.2,{"regimen":202,"formulation":53,"input":415,"expect":417},{"ageYears":247,"weightKg":416},39,{"perDose":104,"mlPerDoseRounded":418},11,{"regimen":222,"formulation":45,"input":420,"expect":421},{"ageYears":269,"weightKg":150},{"perDose":422,"mlPerDose":423},266.67,5.33,{"regimen":241,"formulation":23,"input":425,"expect":427},{"ageMonths":5,"weightKg":426},4,{"perDose":428,"mlPerDose":429},60,2.4,{"regimen":262,"formulation":53,"input":431,"expect":432},{"ageYears":124,"weightKg":247},{"perDose":433,"mlPerDose":434,"mlPerDoseRounded":435},540,6.75,6.8,{"regimen":262,"formulation":53,"input":437,"expect":439},{"ageMonths":426,"weightKg":438},6.5,{"status":440},"blocked",{"regimen":300,"formulation":86,"input":442,"expect":444},{"ageYears":250,"weightKg":443},70,{"tabletsPerDoseRounded":5,"perDay":445},1000,{"regimen":316,"formulation":101,"input":447,"expect":448},{"ageYears":250,"weightKg":443},{"tabletsPerDoseRounded":5},[450],"J01CA04",{"status":452,"forms":453,"refs":514},"registered",[454,458,462,466,470,474,478,482,486,490,494,498,502,506,510],{"code":455,"en":456,"fa":457},"10123","AMOXICILLIN 125MG TAB","قرص آموکسی‌سیلین ۱۲۵ میلی‌گرم",{"code":459,"en":460,"fa":461},"00075","AMOXICILLIN 125MG\u002F5ML 100ML POW SUSP","پودر برای تهیه سوسپانسیون آموکسی‌سیلین ۱۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر، ۱۰۰ میلی‌لیتر",{"code":463,"en":464,"fa":465},"06523","AMOXICILLIN 200MG\u002F5ML 70ML POW SUSP","پودر برای تهیه سوسپانسیون آموکسی‌سیلین ۲۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر، ۷۰ میلی‌لیتر",{"code":467,"en":468,"fa":469},"00076","AMOXICILLIN 250MG CAP","کپسول آموکسی‌سیلین ۲۵۰ میلی‌گرم",{"code":471,"en":472,"fa":473},"02020","AMOXICILLIN 250MG CHEWABLE TAB","قرص جویدنی آموکسی‌سیلین ۲۵۰ میلی‌گرم",{"code":475,"en":476,"fa":477},"10125","AMOXICILLIN 250MG DISPERSIBLE TAB","قرص پراکنده‌شونده آموکسی‌سیلین ۲۵۰ میلی‌گرم",{"code":479,"en":480,"fa":481},"00078","AMOXICILLIN 250MG\u002F5ML 100ML POW SUSP","پودر برای تهیه سوسپانسیون آموکسی‌سیلین ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر، ۱۰۰ میلی‌لیتر",{"code":483,"en":484,"fa":485},"06524","AMOXICILLIN 400MG\u002F5ML 70ML POW SUSP","پودر برای تهیه سوسپانسیون آموکسی‌سیلین ۴۰۰ میلی‌گرم \u002F ۵ میلی‌لیتر، ۷۰ میلی‌لیتر",{"code":487,"en":488,"fa":489},"00077","AMOXICILLIN 500MG CAP","کپسول آموکسی‌سیلین ۵۰۰ میلی‌گرم",{"code":491,"en":492,"fa":493},"13783","AMOXICILLIN 500MG INJ","فرآورده تزریقی آموکسی‌سیلین ۵۰۰ میلی‌گرم",{"code":495,"en":496,"fa":497},"02021","AMOXICILLIN 500MG TAB","قرص آموکسی‌سیلین ۵۰۰ میلی‌گرم",{"code":499,"en":500,"fa":501},"53232","AMOXICILLIN 875 mg TABLET","قرص آموکسی‌سیلین ۸۷۵ میلی‌گرم",{"code":503,"en":504,"fa":505},"53053","AMOXICILLIN POWDER, FOR SUSPENSION ORAL 125 mg\u002F5mL 30 mL","سوسپانسیون خوراکی آموکسی‌سیلین ۱۲۵ میلی‌گرم \u002F ۵ میلی‌لیتر ۳۰ میلی‌لیتر",{"code":507,"en":508,"fa":509},"53073","AMOXICILLIN POWDER, FOR SUSPENSION ORAL 250 mg\u002F5mL 80 mL","سوسپانسیون خوراکی آموکسی‌سیلین ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۸۰ میلی‌لیتر",{"code":511,"en":512,"fa":513},"53074","AMOXICILLIN POWDER, FOR SUSPENSION ORAL 250 mg\u002F5mL 60 mL","سوسپانسیون خوراکی آموکسی‌سیلین ۲۵۰ میلی‌گرم \u002F ۵ میلی‌لیتر ۶۰ میلی‌لیتر",[515],{"source":516,"section":517,"url":518},"darooyab-generic","G-275\u002FAmoxicillin","https:\u002F\u002Fwww.darooyab.ir\u002FG-275\u002FAmoxicillin",[520,524,528,531,534,537],{"kind":521,"url":522,"label":523},"fda","https:\u002F\u002Fwww.accessdata.fda.gov\u002Fscripts\u002Fcder\u002Fdaf\u002Findex.cfm?event=overview.process&ApplNo=065056","ANDA065056",{"kind":525,"url":526,"label":527},"dailymed","https:\u002F\u002Fdailymed.nlm.nih.gov\u002Fdailymed\u002FdrugInfo.cfm?setid=b07b5ac4-253e-4c83-91c3-3fdc46e91a0f","FDA Amoxicillin",{"kind":529,"url":530,"label":8},"medlineplus","https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa685001.html",{"kind":529,"url":532,"label":533},"https:\u002F\u002Fmedlineplus.gov\u002Fdruginfo\u002Fmeds\u002Fa601067.html","Lansoprazole, Clarithromycin, and Amoxicillin",{"kind":535,"url":536,"label":450},"who-atc","https:\u002F\u002Fatcddd.fhi.no\u002Fatc_ddd_index\u002F?code=J01CA04",{"kind":538,"url":518,"label":8},"darooyab",{"pregnancy":540,"lactation":549,"pediatric":557,"geriatric":565},{"level":541,"text":542,"quote":545,"refs":546},"caution",{"fa":543,"en":544},"برچسب خطر مشخصی برای بارداری ذکر نکرده یا داده کافی ندارد؛ فقط در صورت لزوم و با نظر پزشک.","Label states no clear risk or has limited data; use only if needed, under medical advice.","Because animal reproduction studies are not always predictive of human response, amoxicillin should be used during pregnancy only if clearly needed.",[547],{"source":34,"section":548},"8.1",{"level":541,"text":550,"quote":553,"refs":554},{"fa":551,"en":552},"برچسب: در شیردهی با احتیاط؛ متن برچسب را ببینید.","Label: use with caution while breastfeeding; see the label text.","Caution should be exercised when amoxicillin is administered to a nursing woman.",[555],{"source":34,"section":556},"8.3",{"level":541,"text":558,"quote":561,"refs":562},{"fa":559,"en":560},"برچسب برای کودکان شرط، محدودیت سنی یا نکته دارد؛ جمله برچسب در زیر آمده است.","The label has conditions, age limits or notes for children; the label sentence is quoted below.","The safety and effectiveness of amoxicillin for the treatment of upper respiratory tract infections, and infections of the genitourinary tract, skin and skin structure and lower respiratory tract have been established in pediatric patients.",[563],{"source":34,"section":564},"8.4",{"level":541,"text":566,"quote":569,"refs":570},{"fa":567,"en":568},"برچسب: در سالمندان با احتیاط و معمولاً از دوز پایین شروع شود.","Label: use with caution in older adults, usually starting at the low end of the dose range.","Because elderly patients are more likely to have decreased renal function, care should be taken in dose selection, and it may be useful to monitor renal function.",[571],{"source":34,"section":572},"8.5",{"kind":574,"refs":575,"id":523},"ANDA",[576],{"source":34,"section":577},"SPL approval \u002F marketing category",1792440729690]